Aqueous extracts from Uncaria tomentosa (Willd. ex Schult.) DC. reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma

Azevedo, Bruna Cestari de; Morel, Lucas Junqueira de Freitas; Carmona, Fábio; Cunha, Thiago M.; Contini, Sílvia Helena Taleb; Delprete, Piero G.; Ramalho, Fernando Silva; Crevelin, Eduardo José; Bertoni, Bianca Waléria; França, Suzelei de Castro; Borges, Marcos C.; Pereira, Ana Maria Soares

doi:10.1016/j.jep.2018.02.013

Cited by 36 publications

(19 citation statements)

References 57 publications

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“…apples, bananas, coffee, beans) [51]. Chlorogenic acid has been suggested to alleviate lipopolysaccharide (LPS)-induced inflammation and downregulate cyclooxygenase-2 expression -the feature attributed to inflammation in many chronic diseases [52][53][54]. Most of the natural products containing CGAs demonstrate anti-inflammatory effects, and it has been proposed that CGA may be a noticeable anti-oxidative agent [55,56].…”

Section: Discussionmentioning

confidence: 99%

Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts

Wieczfińska

Sitarek

Kowalczyk

et al. 2020

Clinical and Experimental Immunology

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Airway remodeling is a complex process, and controlling it appears to be a key for halting the progression of asthma and other obstructive lung diseases. The aim of this study was to evaluate the anti‐remodeling properties of extracts from transformed and transgenic L. sibiricus roots with overexpression of AtPAP1 transcriptional factor. Our study shows for the first time that transformed AtPAP1 TR extract from L. sibiricus root may affect the remodeling process.

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Section: Discussionmentioning

confidence: 99%

Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts

Wieczfińska

Sitarek

Kowalczyk

et al. 2020

Clinical and Experimental Immunology

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“…The levels of NF-κβ, COX-1, PLA2, CCL2, and CCL5 mRNA were also reduced in RAW 264.7 (macrophage) cells when compared to cells stimulated with LPS. The results obtained suggest that the anti-inflammatory action of Miodesin™ is due, at least in part, to the action of the components of its formulation, either by the action of astaxanthin, reducing proinflammatory cytokine secretion, e.g., IL-1β, IL-6, and TNF-α, and reducing NF-κβ nuclear expression [49,50]; by the action of Uncaria tomentosa, promoting the inhibition of interleukins such as IL-1β, IL-17, and TNFα, in addition to the inhibition of NF-κβ [10,51,52]; or by the action of Endopleura uchi [27,53], inhibiting the action of cyclooxygenases (COX-1 and COX-2) and phos-pholipase A2 (PLA2), reducing the production of proinflammatory cytokines (IFN-γ and TNF-α). Our results, therefore, show the anti-inflammatory activity of Miode-sin™, by regulating the expression and/or secretion of several important inflammatory biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…Natural products have played an important role in the prevention and treatment of human diseases for thousands of years, and in recent decades, great efforts have been made to make natural products more effective and less toxic. Among the plant species present in the Brazilian territory, especially in the Amazon rainforest, we can find Uncaria tomentosa, known as cat's claw [10], a potential natural agent with anti-inflammatory activity, capable of reducing, for example, the expression of TNF-alpha in monocytes [11]. In addition, the specie Endopleura uchi, known as yellow uxi [12], is also found, which presents a marked antioxidant and anti-inflammatory potential [13].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of Miodesin™: Modulation of Inflammatory Markers and Epigenetic Evidence

Oliveira

2020

Oxidative Medicine and Cellular Longevity

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Purpose. To investigate the effects of a combined herbal medicine Miodesin™ on the inflammatory response of key cells involved in the acute and chronic inflammatory processes as well as the possible epigenetic involvement. Methods. After the establishment of the IC50 dose, the chondrocyte, keratinocyte, and macrophage cell lines were pretreated for 2 hours with Miodesin™ (200 μg/mL) and stimulated with LPS (1 μg/mL) for 24 hours. The supernatant was used to measure the levels of cytokines (IL-1β, IL-6, IL-8, and TNF-α) and chemokines (CCL2, CCL3, and CCL5), and the cells were used to extract the mRNA for the transcription factor (NF-κβ), inflammatory enzymes (COX-1, COX-2, PLA2, and iNOS), and chemokines (CCL2, CCL3, and CCL5). Results. Miodesin™ inhibited the release of LPS-induced cytokines (IL-1β, IL-6, IL-8, and TNF-α; p<0.01) and chemokines (CCL2, CCL3, and CCL5; p<0.01) and the expression of the transcription factor (NF-κβ; p<0.01), inflammatory enzymes (COX-1, COX-2, PLA2, iNOS; p<0.01), and chemokines (CCL2, CCL3, and CCL5; p<0.01). In addition, the evaluation of epigenetic mechanism revealed that Miodesin™ did not induce changes in DNA methylation, assuring the genetic safeness of the compound in terms of the inflammatory response. Conclusions. Miodesin™ presents anti-inflammatory properties, inhibiting hyperactivation of chondrocytes, keratinocytes, and macrophages, involving epigenetics in such effects.

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“…Additionally, it was used as a treatment option for mental disorders (e.g., anxiety). Some indigenous people in America used the water stored in the stem to quench thirst, and as a restorative drink [21]. Few pharmacological effects of U. tomentosa have shown in Figure 1.…”

Section: Traditional Usesmentioning

confidence: 99%

Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

et al. 2020

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Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activities, pharmacokinetics, and toxic properties of U. tomentosa extracts.

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Aqueous extracts from Uncaria tomentosa (Willd. ex Schult.) DC. reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma

Cited by 36 publications

References 57 publications

Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts

Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts

Anti-Inflammatory Activity of Miodesin™: Modulation of Inflammatory Markers and Epigenetic Evidence

Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

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