Aqueous Film Coating the Current Trend

608

Modification of surface attributes of particles, usually accomplished by coating, is desirous to enhance and maintain their usability. Coating is a multi-step process involves application of the coating material (CoM) onto the substrate, herein powder particles, where the process along with device/ equipment monitors surface attributes of the applied coating. Nowadays competitive market calls for cost cutting to survive product(s). Thus saving of energy and time, minimising number and quantity of additives, reducing and shortening process steps; consequently minimising the coating process cost are main goals while developing coating process for powder particle. Innovation of processes for dry-powder coating (DPC) along with their further development and refinement finds solution to said issues. Further, DPC process does not calls for liquid solvent or solution thus are viewed as cost-effective and environmentally safe, DPC process uses thermo-mechanical methods like mechanofusion, magnetic assisted impaction coating (MAIC), hybridization, rotating fluid-bed process, theta-composer, hot-melt coating (HMC), and many others. Besides these available are non-thermo-mechanical methods namely electrostatic coating; supercritical fluids (SCF) based methods like rapid expansion of supercritical fluid (RESF), gas anti-solvent (GAS), SCF anti-solvent, gas-saturated solution (GSS); vapour coating; and others. Basing on said thermo-mechanical and non-thermo-mechanical principle several DPC methods/ process had been reported in scientific literatures and patents. Said DPC method founds multidisciplinary applications like drug delivery and drug development. Diverse devices are there for the DPC process; their method of working, principle, limitations and benefits along with their applicability in pharmaceutical field are discussed and presented in this article. Keywords: Dry, particle, coating, pharmaceutical, process

Section: Introductionmentioning

confidence: 99%

Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Alli¹

2021

608

“…Wide diversity of the coating process/ methodologies is inherited with complex processing steps and with complexity of diverse origin and type 1,3,8 . Discussing all of them, a vast area and versatile field, is an immense task and out of scope of this manuscript 4,9 .…”

Section: Introductionmentioning

confidence: 99%

Specialised Coating Processes Finding Pharmaceutical Applicability

Saikh¹,

Mohapatra²

2021

Self Cite

256

The manuscript aims at furnishing comprehensive information pertaining specialised coating technology/ processes. Solid dosage forms and solid particulates (SDFSP) are the major contributing group in the solid pharmaceuticals (SoPs). SDFSP exhibit peculiar physico-chemical properties and interaction behaviour which create problems/ issues during their handling, processing, storage, and use. Modifying and/or engineering surface attributes of SDFSP are advocated as powerful tool to modify their interaction behaviour and realise their worthy applications and functionalities. In this regard coating their surfaces with coating material (CM) is novel approach. Said approach involves wet and dry process for realising deposition of CM onto the surface of SDFSP substrates. Both the processes modify and/or alter innate properties of SDFSP substrates either physically or chemically. Basing on involved wet or dry process the coating method is either dry coating method (DCM) or wet coating method (WCM). Accordingly nowadays there available number of specialised devices, that bases on diverse technologies. Amongst them some involves state-of-art process/ technology like Supercell coating technology (SCT), Chemical vapour deposition (CVD), Atomic/molecular layer deposition (AMLD), Electrostatic deposition, Thermo-mechanical process, Resonant acoustic technology, Fluidised-bed process, Supercritical fluid (SCF) technology, and others. These foundational for commercially availability of specialised equipments like Magnetically Assisted Impaction Coater (MAIC), Resodyn acoustic mixer, Hybridizer®, Theta-composer®. Mechanofusion®, and others. Working and working principle, applicability, benefits, pros and limitations of specialised coating processes and technologies are herein discussed and presented. Contained information hoped to be beneficent for pharmaceutical professionals and technocrats and professionals of allied field. Keywords: Coating, composite product, modification, specialised, surface.

“…Modification of surface and surface attributes of FiUlFiPs can be achieved by coating/depositing an appropriate additive on their surfaces [1][2][3] . The processes of coating/ deposition, by method of either physical deposition or chemical deposition, is for modifying surface attributes of FiUlFiPs are complex one 4,[6][7][8] . Physical deposition method uses thermal, mechanical, thermo-mechanical, electro-mechanical, or thermodynamic means to produce a thin film of solid at surface of FiUlFiPs 1-3, 7, 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Physical deposition method uses thermal, mechanical, thermo-mechanical, electro-mechanical, or thermodynamic means to produce a thin film of solid at surface of FiUlFiPs 1-3, 7, 8 . Chemical deposition methods involve occurring of chemical changes of a fluid precursor at surface of FiUlFiPs, leaving a solid-layer of coating 6,7 . Examples are Photo curable coating or photo-curing, gas/vapour phase deposition (like chemical vapour deposition, Atomic/molecular layer deposition) 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…Technologies of them involve use of high pressures, high shear, elevated temperatures, and/or solvents 2,3 . Solvent based wet coating methods have become less preferable as can reduce stability, cause particle agglomeration, leave residual organic solvents, and environmental concerns, arousing from unwanted waste streams and possible emissions of volatile organic solvents 2,4,[6][7][8] . The strategies involving chemical deposition inherit ISSN: 2250-1177…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals

Saikh¹,

Mohapatra²

2021

Self Cite

189

The manuscript aims to provide glimpse on updated information relating thermo-mechanical dry coating processes (TMDCP) suiting in modifying surface attributes of fine and ultra-fine particle (FiUlFiP). FiUlFiPs are the integral component of pharmaceutical processes. They exhibit complex and queer properties, are conferred mostly from their surface attributes colligated with their higher surface area. Particle engineering technocrats extensively working for modifying surface & surface attributes of FiUlFiPs. These efforts are to find their worthy applications & new functionalities. Among available diverse particle engineering technologies/ process, TMDCP, a dry coating process (DCP), advocated being worthy and efficient. The TMDCP finds multidisciplinary applications, mostly in drug development & drug delivery. Said DCP involves fixing and/or attaching coating material (CoM) as particles herein synonym guest particle (GP) onto core/substrate particle (CSP) herein synonym host particle (HP). Attaching/ fixing the GPs onto HPs, in TMDCP, involve their mechanical and/or thermal interactions. Scientific literatures are evidencing diverse techniques and/or process, basing on discussed interactions. Amongst them novel techniques/ processes are Hybridization, Magnetically assisted impaction coating process (MAICP), Mechanofusion, Theta-composer, and high shear compaction. In this area diverse devices/ equipments are prevailing in market. Important are Hybridizer, Magnetically assisted impaction coater (MAIC), Theta-composer, Mechanofusion, Quadro Comil®, Cyclomix®, and many others. Attempt of this article is to discuss and present their method of working, working principle, applicability, limitations, and benefits. Contained information might be beneficial for professionals of pharmaceutical and allied field. Keywords: dry coating, equipment, particles, processes, thermo-mechanical.