Aqueous Ginger (Zingiber officinale) Extract Ameliorates the Harmful Effects of High-Dose Lornoxicam in Albino Male Rats

Abstract

Lornoxicam is a potent oxicam-class nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic effects. Its impacts on many biological functions are not fully understood. We measured various biomarkers in male albino rats provided an oral aqueous ginger extract before IM administration of therapeutic and 2× the therapeutic doses of lornoxicam. The aqueous ginger plant extract was characterized by mass spectroscopy, and its effects were determined by examining free radical scavenging activity, blood parameters, renal and hepatic function, semen quality, proinflammatory cytokines, antioxidant markers, and histopathology. Rats administered lornoxicam had significantly higher liver and kidney function biomarker values, TNF-α, interleukin-6, and sperm abnormalities than the control rats. The overall erythrocyte count, packed cell volume, prostaglandin, and sperm counts were all considerably lower in the experimental animals. Histological changes were found in the liver, spleen, and testes of rats administered lornoxicam alone. In rats, pretreatment with ginger extract reduced the majority of the negative effects of conventional and high dosages of lornoxicam.

Therapeutic Potential of Ginger Extract on the Embryotoxicity and Nephrotoxicity Induced by Labetalol in Rat Fetuses

“…This study revealed that ginger significantly ameliorated the histological and ultrastructural effects induced by labetalol in fetal renal tissue. Many recent studies confirmed the therapeutic effect of ginger against nephrotoxicity (Dawood et al, 2022;El-Bahr et al, 2022). Ali et al (2020) reported that the ethanolic extract of Z. officinale (200 mg orally for 8 weeks) had a protective effect on the renal damage induced by mercuric chloride in rats.…”

“…Moreover, ginger treatment during pregnancy does not increase the risk of congenital malformations, stillbirth, perinatal death, preterm birth, or low birth weight (Weidner and Sigwart, 2000;Heitmann et al, 2013). Furthermore, the therapeutic role of ginger against renal damage has been demonstrated (Tzeng et al, 2013;Gholampour et al, 2017;Pratap et al, 2017;El-Bahr et al, 2022).…”

Effects of ginger extract and/or propolis extract on immune system parameters of vaccinated broilers

“…The ginger and propolis extracts were gathered from the local market at Alexandria, identified by botanists at the faculty of Agriculture Alexandria University, then air-dried and ground into fine powder. At room temperature, 150 g of ginger powder was macerated in 200 mL of distilled water for 24 h, then filtered and concentrated in a rotary evaporator to obtain the final ginger aqueous extract ( El-Bahr et al, 2022 ). About 200 g of propolis powder was soaked in 500 mL distilled water for 2 h at 70°C under the filtered and concentrated stirring to obtain the final propolis aqueous extract ( de Moura et al, 2011 ).…”