Arachidonic acid metabolism: A primer for head and neck surgeons

Ondrey, Frank G.

doi:10.1002/(sici)1097-0347(199807)20:4<334::aid-hed9>3.0.co;2-#

Cited by 20 publications

(11 citation statements)

References 73 publications

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“…Prostaglandins including PGE 2 are derived from arachidonic acid, a phospholipid component of cell membranes (Ondrey, 1998). Cycloxygenases (COX) are the key enzymes responsible for the conversion of arachidonic acid into prostaglandines.…”

Section: Discussionmentioning

confidence: 94%

Anticancer Activity of Scutellaria baicalensis and Its Potential Mechanism

Xui

et al. 2002

The Journal of Alternative and Complementary Medicine

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Scutellaria baicalensis strongly inhibits cell growth in all cancer cell lines tested. However, prostate and breast cancer cells (PC-3, LNCaP, and MCF-7) are slightly more sensitive than other type of cancer cells. It also inhibits PGE(2) production, indicating that suppression of tumor cell growth may be due to its ability to inhibit COX-2 activity. This study supports the notion of using Scutellaria baicalensis as a novel anticancer agent to treat various cancers.

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Section: Discussionmentioning

confidence: 94%

Anticancer Activity of Scutellaria baicalensis and Its Potential Mechanism

Xui

et al. 2002

The Journal of Alternative and Complementary Medicine

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“…COX consists of two isoforms, COX-1 and COX-2 (12). COX-1 is constitutively expressed in most tissues for physiologic homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Cox-2 and IL-10 Polymorphisms and Association with Squamous Cell Carcinoma of The Head and Neck in a Korean Sample

et al. 2010

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Cyclooxygenase-2 (COX-2) is involved in inflammation and carcinogenesis. Interleukin-10 (IL-10) is also regarded as anti-inflammatory factors with the multi-functional ability to positively and negatively influence functional immunity and tumor development. Genetic polymorphisms of COX-2 and IL-10 might contribute to the development of squamous cell carcinoma of the head and neck (SCCHN). The purpose of this study was to evaluate the association of COX-2 and IL-10 single nucleotide polymorphisms (SNPs) with the risk of SCCHN in a Korean sample. We analyzed the COX-2 SNPs, -1329A>G, +1266C>T, and +6365T>C, and the IL-10 SNPs, -1082A>G, +920T>G, and +3917T>C, in 290 Korean SCCHN patients and 358 healthy controls. There was no significant association between the risk of SCCHN and the three COX-2 or three IL-10 SNPs. We analyzed three haplotypes (ht1, ht2, ht3) for COX-2 and found that COX-2 ht3+/+ was associated with a decreased risk of SCCHN in a Korean sample, compared with the COX-2 ht3 -/- genotype (P=0.03). Two haplotypes (ht1, ht2) of IL-10 were analyzed and there was no statistical significance in the distribution of haplotypes. Based on these results, the COX-2 haplotype ht3 can be used as a molecular biomarker to predict low risk groups of SCCHN in a Korean sample.

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“…The concentration of prostaglandin (PG) has been found to be increased in several cancers, and studies on the effect of PG and its metabolites on the growth and metastasis of cancer are ongoing actively [1-3]. PG is produced through the action of cyclooxygenase (COX), the rate limiting enzyme of the arachidonic acid metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of NSAID suppressing the development of colon cancer has not been elucidated yet; nonetheless, it is thought to reduce the production of PG by interfering with COX activity and to exert effects on cell growth, apoptosis and immune reactions [3, 10]. Nevertheless, clinical studies have revealed that COX inhibitors, including NSAID, are restricted to use as therapeutics because of gastrointestinal disturbance and cardiovascular impairments [11].…”

Section: Introductionmentioning

confidence: 99%

Relation of the Expression of Cyclooxygenase-2 in Colorectal Adenomas and Adenocarcinomas to Angiogenesis and Prognosis

Han

Hong²,

Kang³

et al. 2010

J Korean Soc Coloproctol

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PurposeRecent studies have shown that cyclooxygenase (COX)-2 may be involved in tumor growth, invasion and apoptosis in various carcinomas. Vascular endothelial growth factor (VEGF) has a potent angiogenic activity, and COX-2 promotes angiogenesis by modulating angiogenic factors, including VEGF. Endothelial growth factor receptor (EGFR) is considered as a factor of cell growth, maturation and cell death. The current study was designed to investigate the possible roles of COX-2 in colorectal tumor progression and angiogenesis.MethodsFifty colorectal adenomas and forty adenocarcinomas were investigated by using immunohistochemical staining for COX-2, VEGF and EGFR. The correlations of COX-2, VEGF and EGFR with the grade of dysplasia, the size of the adenoma, and various clinicopathologic factors were studied.ResultsThe expressions of COX-2, VEGF and EGFR were each significantly correlated with carcinomatous transformation, and the expressions of COX-2 and VEGF were significantly correlated. COX-2 and EGFR showed correlations with adenomas rather than adenocarcinomas. However, no correlations of COX-2, VEGF and EGFR expression to other clinicopathologic factors, except tumor size in EGFR expression, were detected.ConclusionThese results suggest that COX-2 may play an important role in carcinogenesis through interaction with VEGF and EGFR in human colorectal cancer.

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Arachidonic acid metabolism: A primer for head and neck surgeons

Cited by 20 publications

References 73 publications

Anticancer Activity of Scutellaria baicalensis and Its Potential Mechanism

Anticancer Activity of Scutellaria baicalensis and Its Potential Mechanism

Cox-2 and IL-10 Polymorphisms and Association with Squamous Cell Carcinoma of The Head and Neck in a Korean Sample

Relation of the Expression of Cyclooxygenase-2 in Colorectal Adenomas and Adenocarcinomas to Angiogenesis and Prognosis

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