Abstract-The potential for destructive interference between running processes is increased as Chip Multiprocessors (CMPs) share more on-chip resources. We believe that understanding the nature of memory system interference is vital to achieve good fairness/complexity/performance trade-offs in CMPs. Our goal in this work is to quantify the latency penalties due to interference in all hardware-controlled, shared units (i.e. the onchip interconnect, shared cache and memory bus). To achieve this, we simulate a wide variety of realistic CMP architectures. In particular, we vary the number of cores, interconnect topology, shared cache size and off-chip memory bandwidth. We observe that interference in the off-chip memory bus accounts for between 63% and 87% of the total interference impact while the impact of cache capacity interference can be lower than indicated by previous studies (between 5% and 32% of the total impact). In addition, as much as 11% of the total impact can be due to uncontrolled allocation of shared cache Miss Status Holding Registers (MSHRs).