The problems of Russia's spatial development and accompanying disparities are considered. The authors express their position with regard to the currently devised Strategy for Spatial Development of the Russian Federation and formulate conceptual provisions that should be reflected in it. Analysis is performed for the strategic priorities of spatial development of Russia and Siberia, as well as trends, challenges, and threats that can change the development vectors of the country's macroregions. Special attention is paid to the positioning of Siberia in the Russia's eastern development vector and, in particular, to the problems of development and interaction between the regions of Siberia, the Russian Far East, and northeastern China. Some issues of reconciliation between the Eurasian Economic Union and the economic belt of the Great Silk Road, as well as the implementation of the strategic initiative One Belt-One Way are considered.