Are adjuvant radiotherapy outcomes really better in patients with early‐stage oral cavity squamous cell carcinoma?

Subash, Anand; Rao, Vishal

doi:10.1002/cncr.31797

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…The NCCN guidelines recommend that for patients with T1‐2N0 oral cancer without risk factors, follow‐up after surgery is feasible 5 . Several studies have demonstrated insignificant benefits of adjuvant postoperative radiotherapy in early‐stage TSCC 20,40 . While other studies found that OS of patients with oral cancer (T1‐2N1) benefited from postoperative adjuvant therapy when the number of LND was <18 41 or when lymph node ratio (LNR) was >5.5% in OTSCC patients 42 .…”

Section: Discussionmentioning

confidence: 99%

“… 5 Several studies have demonstrated insignificant benefits of adjuvant postoperative radiotherapy in early‐stage TSCC. 20 , 40 While other studies found that OS of patients with oral cancer (T1‐2N1) benefited from postoperative adjuvant therapy when the number of LND was <18 41 or when lymph node ratio (LNR) was >5.5% in OTSCC patients. 42 Fridman et al 20 also reported that adjuvant therapy significantly improved survival when there were positive/close margin for patients with T1–2N0M0 oral cavity squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic factors in surgically treated tongue squamous cell carcinoma in stage T1‐2N0‐1M0: A retrospective analysis

Wang,

Zeng

et al. 2024

Cancer Medicine

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PurposeThe study aimed to retrospectively identify the prognostic factors of surgically treated primary tongue squamous cell carcinoma (TSCC) cases and assess the benefits of surgical neck lymph node dissection (LND) in early‐stage cancer.MethodsPatients with primary TSCC with pT1‐2N0‐1M0 stage without distant metastasis who were treated with surgery during 2014–2016 at Xiangya Hospital, Central South University were included. Univariate and multivariate Cox models were constructed to explore prognostic factors of overall survival (OS), disease‐free survival (DFS), and local recurrence‐free survival (LRFS). Sub‐group analysis was used to assess the effect of adjuvant therapy and the prognostic value of LND for the early‐stage patients.ResultsIn total, 440 patients met the inclusion criteria. During the follow‐up period, the 5‐year OS, DFS, were 84.4% and 70.0%, respectively. Univariate analysis showed that TNM stage, lymphovascular invasion (LVI), and/or perineural invasion (PNI), pathological differentiation, etc. were significant predictors of OS and DFS. Multivariate analysis showed that TNM stage and the degree of pathological differentiation were independent prognostic factors for all outcomes. Besides, the number of cervical LND could independently predict both DFS and LRFS while LVI/PNI were associated with DFS. And high‐quality neck LND (≥30) significantly improved DFS and LRFS for patients of pT1cN0M0 or stage I as compared to those without LND.ConclusionsTNM stage and pathological differentiation were crucial prognostic factors for postoperative patients with TSCC. Notably, high‐quality cervical LND was beneficial for the improvement of DFS and LRFS for patients of pT1cN0M0 or stage I.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic factors in surgically treated tongue squamous cell carcinoma in stage T1‐2N0‐1M0: A retrospective analysis

Wang,

Zeng

et al. 2024

Cancer Medicine

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“…However, it is known that there is an increased likelihood of narrow deep resection margins in deep invading tumors. In their study, close resection margins might have correlated with DOI, and thereby responsible for higher risk of recurrence [ 32 – 36 ].…”

Section: Discussionmentioning

confidence: 99%

Need for adjuvant radiotherapy in oral cancer: depth of invasion rather than tumor diameter

Riemenschnitter

Morand

Schouten

et al. 2022

Eur Arch Otorhinolaryngol

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Purpose The 8th edition of the TNM Cancer Staging Manual incorporates depth of invasion (DOI) into the pathologic tumor classification for oral squamous cell carcinoma (OSSC). While deep invading tumors with small tumor diameters (TD) have been categorized as early stage tumors in the 7th edition, they are now upstaged, potentially influencing the decision to initiate adjuvant radiotherapy (RT). Methods OSCC patients surgically treated with curative intent between 2010 and 2019 were consecutively included. Tumors were staged based on TD only (according to the 7th edition TNM Cancer Staging Manual), then restaged based solely on DOI. Results Of the 133 included patients, 58 patients (43.6%) had a different pT-stage when using DOI instead of TD for staging (upstaging in 23.3%). Overall survival (OS) was significantly worse in patients who were upstaged with DOI. In addition, stratification by adjuvant RT showed significant worse OS in upstaged patients without receiving adjuvant RT. Conclusions DOI seems to be an import indicator for adjuvant RT in OSCC-patients.

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Role of Adjuvant Radiotherapy in Early Stage Tongue Cancer: Need for Establishing Stringent Guidelines

Rao

Subash

Sinha

et al. 2021

Indian J Surg Oncol

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Are adjuvant radiotherapy outcomes really better in patients with early‐stage oral cavity squamous cell carcinoma?

Cited by 4 publications

References 7 publications

Prognostic factors in surgically treated tongue squamous cell carcinoma in stage T1‐2N0‐1M0: A retrospective analysis

Prognostic factors in surgically treated tongue squamous cell carcinoma in stage T1‐2N0‐1M0: A retrospective analysis

Need for adjuvant radiotherapy in oral cancer: depth of invasion rather than tumor diameter

Role of Adjuvant Radiotherapy in Early Stage Tongue Cancer: Need for Establishing Stringent Guidelines

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