Are antibiotic effects on sleep behavior in the rat due to modulation of gut bacteria?

Brown, Richard A.; Price, Rhelma J.; King, Maurice G.; Husband, Alan J.

doi:10.1016/0031-9384(90)90300-s

Cited by 46 publications

(18 citation statements)

References 12 publications

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“…It is in fact derived from the bacterial cell wall and thus released by gut bacteria (Collins & Bercik, 2009) and it provides yet another example of how bacterial products can influence brain activity and function. Rats given a strict antibiotic regimen exhibited greatly reduced slow-wave sleep and increased sleep onset latency (Brown, Price, King, & Husband, 1990). …”

Section: Biomarkers Of Interestmentioning

confidence: 99%

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

Ghaisas

Maher

Kanthasamy

2016

Pharmacology & Therapeutics

445

280

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The gut microbiome comprises the collective genome of the trillions of microorganisms residing in our gastrointestinal ecosystem. The interaction between the host and its gut microbiome is a complex relationship whose manipulation could prove critical to preventing or treating not only various gut disorders, like irritable bowel syndrome (IBS) and ulcerative colitis (UC), but also central nervous system (CNS) disorders, such as Alzheimer’s and Parkinson’s diseases. The purpose of this review is to summarize what is known about the gut microbiome, how it is connected to the development of disease and to identify the bacterial and biochemical targets that should be the focus of future research. Understanding the mechanisms behind the activity and proliferation of the gut microbiome will provide us new insights that may pave the way for novel therapeutic strategies.

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Section: Biomarkers Of Interestmentioning

confidence: 99%

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

Ghaisas

Maher

Kanthasamy

2016

Pharmacology & Therapeutics

445

280

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“…Studies suggest that GI bacteria are an important source of Factor-S because normal sleep patterns were disrupted after perturbation of the microbiota with oral antibiotics. 76,77 Commensal bacteria also produce precursors of benzodiazepine receptor ligands that could contribute to encephalopathy in a rat model of liver failure. 46 Cognitive function improved in patients with minimal hepatic encephalopathy given Bifidobacterium longum with fructo-oligosaccharide for 9 weeks.…”

Section: Ability Of Microbiota To Influence the Brain And Behaviormentioning

confidence: 99%

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

2009

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“…In the present study, we highlight a previously unrecognized risk factor, namely antibiotic-induced dysbiosis, and call attention to the profound implications for clinical practice given that more than 270 million antibiotic prescriptions are issued in the US each year (Suda et al, 2014). There is now direct experimental evidence in mice (this study), rats (Brown et al, 1990), and humans (Nonaka et al, 1983) indicating that antibiotics may be insomnogenic. Additionally, Perlis et al (2006) used the Physicians' Desk Reference to document the clinical occurrence of insomnia with respect to seven classes of antibiotics and found that five of the classes were associated with insomnia as a side effect.…”

Section: Discussionmentioning

confidence: 75%

Sleep and the gut microbiome: antibiotic-induced depletion of the gut microbiota reduces nocturnal sleep in mice

Lendrum

Seebach

Klein

et al. 2017

Preprint

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Highlights-14 d broad-spectrum antibiotic treatment effectively depletes the gut microbiota.-Gut microbiota depletion reduces nocturnal sleep, but not diurnal sleep.-Gut microbiota depletion increases nocturnal locomotion, but not diurnal locomotion.-Antibiotics may be insomnogenic: implications for idiopathic sleep disorders. AbstractSeveral bacterial cell wall components such as peptidoglycan and muramyl peptide are potent inducers of mammalian slow-wave sleep when exogenously administered to freely behaving animals. It has been proposed that the native gut microflora may serve as a quasi-endogenous pool of somnogenic bacterial cell wall products given their quantity and close proximity to the intestinal portal. This proposal suggests that deliberate manipulation of the host's intestinal flora may elicit changes in host sleep behavior. To test this possibility, we evaluated 24 h of sleep-wake behavior after depleting the gut microbiota with a 14 d broad-spectrum antibiotic regimen containing high doses of ampicillin, metronidazole, neomycin, and vancomycin. Highthroughput sequencing of the bacterial 16S rDNA gene was used to confirm depletion of fecal bacteria and sleep-wake vigilance states were determined using videosomnography techniques based on previously established behavioral criteria shown to highly correlate with standard polysomnography-based methods. Additionally, considering that germ-free and antibiotic-treated mice have been earlier shown to display increased locomotor activity, and since locomotor activity has been used as a reliable proxy of sleep, we suspected that the elevated locomotor activity previously . CC-BY 4.0 International license peer-reviewed) is the author/funder. It is made available under aThe copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/199075 doi: bioRxiv preprint first posted online Oct. 5, 2017; reported in these animals may reflect an unreported reduction in sleep behavior. To examine this potential relationship, we also quantified locomotor activity on a representative subsample of the same 24 h of video recordings using the automated video-tracking software ANY-maze. We found that antibiotic-induced depletion of the gut microbiota reduced nocturnal sleep, but not diurnal sleep. Likewise, antibiotictreated mice showed increased nocturnal locomotor activity, but not diurnal locomotor activity. Taken together, these results support a link between the gut microbiome and nocturnal sleep and locomotor physiology in adult mice. Additionally, our findings indicate that antibiotics may be insomnogenic via their ability to diminish gut-derived bacterial somnogens. Given that antibiotics are among the most commonly prescribed drugs in human medicine, these findings have important implications for clinical practice with respect to prolonged antibiotic therapy, insomnia, and other idiopathic sleep-wake and circadian-rhythm disorders affecting an estimated 50-70 million people in the United States alone.

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Are antibiotic effects on sleep behavior in the rat due to modulation of gut bacteria?

Cited by 46 publications

References 12 publications

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

Sleep and the gut microbiome: antibiotic-induced depletion of the gut microbiota reduces nocturnal sleep in mice

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