Are erythema nodosum-like lesions and superficial thrombophlebitis prodromal in terms of visceral involvement in Behcet's disease?

Abstract

Erythema nodosum (EN)-like lesions and superficial thrombophlebitis (ST) are skin symptoms that are frequently observed in Behcet's disease. In most of the patients, skin symptoms precede serious visceral involvement. The study included 78 patients whose mean age was 33.48 +/- 6.16 (21-48). Of the cases, 37 were females and 41 were males. Forty-two patients (53.8%) had EN-like lesion and 12 (15.3%) had ST. Six of 54 patients, who had EN-like lesion and ST, were found to have no visceral involvement. In six of the remaining 48 patients, it was established that visceral involvement developed before lesions. It was found in 42 patients that these two lesions preceded visceral involvement. In addition, 18 of 24 patients who did not have these two lesions, do not still have visceral involvement. Therefore, we think that EN-like lesion and ST can be guiding in predicting serious visceral involvement and complications that can develop in advanced stages of Behcet's disease.

Erythema Nodosum-like Lesions in Behçet’s Disease: A Clinicopatho­logical Study of 26 Cases

“…However, previous studies have suggested that EN-like lesions in BD are more commonly seen in Japanese females than males. In addition, a report from Turkey, in which BD is more common among males than females (1.1:1) (2), also showed a female predominance in BD patients who had EN-like lesions, (M/F ratio 0.62) (19). Therefore, the female predominance in this study, of BD patients who presented at the dermatological clinic with EN-like lesions, may be an expected finding.…”

“…The present study suggested that the presence of severe vasculitis, especially phlebitis, in EN-like lesions may be an indicator of the involvement ofthe gastrointestinal tract in BD. A previous report suggested that the presence of EN-like lesions is a prognostic factor for the development of superficial thrombophlebitis (5), and another report proposed that the presence of EN-like lesions and superficial thrombophlebitis is a predicting factor for the visceral involvement in BD (19), although these 2 reports did not distinguish between EN-type or vasculitis type lesions.…”

Ten‐year history of erythematous nodules on the lower extremities

“…One clinical entity that has been known to include concomitantly both EN and superficial thrombophlebitis is Behc ßet disease. [11][12][13] Owing to lack of mucosal ulceration or other stigmas of Behc ßet disease, this entity was not considered further in this patient. While thrombophlebitis can masquerade as EN clinically, it can also be a direct cause of true EN.…”

Felületes vénás thrombosis – ahogy ma látjuk

“…Elsősorban a kis artériák mediumát érintő, gyulladásos, okkluzív betegség. A betegség egyik diagnosztikus kritériuma az SVT, ami főleg mint thrombophlebitis migrans vagy saltans jelentkezik [52]. Egy 22 Bürger-kóros betegre vonatkozó vizsgálat során nyolc betegen (36,4%-ban) észleltek SVT-t [53].…”

“…2319 Behçet-szindrómás beteg 53,3%-án alakult ki SVT és 29,8%-án MVT [54]. Spontán SVT és erythema nodosumszerű laesiók gyakran előjelei a betegség súlyos, visceralis szövődményeinek [52].…”