Are genotypes of glutathione S-transferase superfamily a risk factor for childhood acute lymphoblastic leukemia? Results of an Italian case–control study

Pigullo, Simona; Haupt, Riccardo; Dufour, Carlo; Michele, Paola Di; Valsecchi, M.G.; Basso, Giuseppe; Rizzari, Carmelo; Biondi, Andrea; Lanciotti, Marina

doi:10.1038/sj.leu.2404617

Cited by 9 publications

(9 citation statements)

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“…As a result, GSTP1 is commonly studied for its effect on the susceptibility to acute myeloid leukemia (Allan et al, 2001). In recent years, a number of molecular epidemiologic studies have been conducted to evaluate the role of the A1578G polymorphism in the GSTP1 gene on childhood ALL risk; however, the results remain conflicting rather than conclusive (Krajinovic et al, 2002b;Balta et al, 2003;Barnette et al, 2004;Canalle et al, 2004;Clavel et al, 2005;Gatedee et al, 2007;Pigullo et al, 2007;Chan et al, 2011). Meta-analysis is a powerful statistical method that can provide a quantitative approach for pooling the results of different studies on the same topic, and thus a systematic review and meta-analysis of the association between the GSTP1 A1578G polymorphism and childhood ALL risk is of great value.…”

Section: Discussionmentioning

confidence: 99%

“…Their full texts were retrieved and carefully studied. Finally, a total of 8 eligible studies involving 1384 cases and 1755 controls were included in the pooled analyses (Krajinovic et al, 2002b;Balta et al, 2003;Barnette et al, 2004;Canalle et al, 2004;Clavel et al, 2005;Gatedee et al, 2007;Pigullo et al, 2007;Chan et al, 2011). The characteristics of the selected studies are summarized in Table 1.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

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The GSTP1 A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia: results from an updated meta-analysis

Huang¹,

Shan²,

Zeng³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Studies investigating the association between the glutathione S-transferase P1 (GSTP1) A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia (ALL) report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Wangfang databases for studies of the polymorphism and ALL. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for the GSTP1 polymorphism and childhood ALL were calculated in a fixed-effect model. Pooled ORs were calculated for a co-dominant model (GG vs AA, AG vs AA), a dominant model (GG + AG vs AA), and a recessive model (GG vs AA + AG). Analyses were also performed in subgroups stratified by race, study design, genotyping methods, and study sample size. This meta-analysis included 8 case-control studies with 1384 childhood ALL cases and 1755 controls. Overall, the variant genotypes (GG and AG) of A1578G were not associated with childhood No heterogeneity or publication bias was observed in the present study. This updated meta-analysis indicates that the GSTP1 A1578G polymorphism is not associated with the risk of childhood ALL. In the future, additional studies in Asian and African-American patients should be performed to re-evaluate the association in these populations.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

The GSTP1 A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia: results from an updated meta-analysis

Huang¹,

Shan²,

Zeng³

et al. 2013

Genet. Mol. Res.

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“…Fifteen studies [30][31][32]35,37,40,[58][59][60][61][62][63][64] have examined the relationship between GSTM1 and GSTT1 and ALL risk ( Table S2). Five of the studies reported a statistically significant increased risk associated with GSTM1 deletion.…”

Section: Meta-analysismentioning

confidence: 99%

“…Only five studies examined the relationship between Bcell ALL and risk. 30,40,41,44,64 Among the three studies 40,41,44 that looked at MTHFR C677T and risk, one study had irregularities in the genotype data presented 40 hence data from the study could not be pooled. Combining data from the other two studies showed that C677T was not significantly associated with risk (Table 2; Online Supplementary Figure S1; Online Supplementary Table S2).…”

Section: Meta-analysismentioning

confidence: 99%

“…Combining data from the other two studies showed that C677T was not significantly associated with risk (Table 2; Online Supplementary Figure S1; Online Supplementary Table S2). Of the three studies 30,40,64 which examined the relationship between GSTM1 and risk of B-cell ALL, only two 30,40 had extractable genotype data. One of the studies was significantly associated with risk.…”

Section: Meta-analysismentioning

confidence: 99%

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Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis

Vijayakrishnan¹,

Houlston²

2010

Haematologica

111

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To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to childhood acute lymphoblastic leukemia we conducted a systematic review and meta-analysis of published studies (January 1996-July 2009. Studies had to meet the following criteria: be case-control design, be studied by two or more studies, not be focused on HLA antigen genetic markers and be published in English. We identified 47 studies of polymorphic variation in 16 genes and acute lymphoblastic leukemia risk. To clarify the impact of individual polymorphisms on risk, pooled analyses were performed. Of the 25 polymorphic variants studied, significant associations (P<0.05) were seen in pooled analyses for eight variants: GSTM1 (OR =1.16; 95%CI: 1.04-1.30), MTRR A66G (OR=0.73, 95%CI:0.59-0.91), SHMT1 C1420T (OR=0.79, 95%CI: 0.65-0.98), RFC1 G80A (OR=1.37, 95%CI: 1.11-1.69), CYP1A1*2A (OR=1.36, 95%CI:1.11-1.66), CYP2E1*5B (OR=1.99, 95%CI:1.32-3.00) NQO1 C609T (OR=1.24, 95%CI:1.02-1.50) and XRCC1 G28152A (OR=1.78, 95%CI:1.32-2.42). These findings should, however, be interpreted with caution as the estimated false-positive report probabilities (FPRP) for each association were not noteworthy (i.e. FPRP>0.2). While candidate gene analyses are complementary to genome-wide association studies, future analyses should be based on sample sizes commensurate with the detection of small effects and attention needs to be paid to study design.Key words: polymorphisms, acute lymphoblastic leukemia, risk, meta-analysis, false positive report probabilities. -analysis. Haematologica 2010;95(8):1405-1414. doi:10.3324/haematol.2010 This is an open-access paper. Citation: Vijayakrishnan J and Houlston RS. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta IntroductionAcute leukemia is the major pediatric cancer in developed countries, affecting between 30-45 per 1,000,000 children each year.1 Dysregulated immune response to infection may be a cause of childhood acute lymphoblastic leukemia (ALL) 2 and epidemiological data are consistent with transplacental carcinogen exposure as a basis for infant leukemia associated with MLL gene fusion, 3 but the role of environmental carcinogenesis in ALL is currently undefined. It is, however, likely that the risk of ALL from environmental exposure is influenced by co-inheritance of multiple low-risk variants.The commonest method for identifying common low-risk variants is through association studies. These are based on comparing the frequency of polymorphic genotypes in cases and controls. Alleles positively associated with the disease are analogous to risk factors in epidemiology and may be causally related to disease risk or in linkage disequilibrium with disease-causing variants. There are a number of different methods of analyzing the risk associated with a specific variant. For simple bi-allelic polymorphisms, the odds ratio of disease can be derived by comparing allele frequencies in cases and controls. This ap...

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Glutathione-S-transferase polymorphism and acute lymphoblastic leukemia (ALL) in north Indian children: a case–control study and meta-analysis

et al. 2014

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Various studies on association of glutathione S-transferase (GST) polymorphisms and childhood acute lymphoblastic leukemia (ALL) have yielded conflicting results. We examined this association among north Indian children and conducted an updated meta-analysis to overcome sample size-related limitations. GSTM1, GSTP1 and GSTT1 genotypes in 100 children with ALL and 300 healthy controls were compared. GSTT1 null mutation (odds ratio (OR) 2.54, 95% confidence interval (CI) 1.50-4.32) and GSTP1 homozygous mutation (OR 3.13, 95%CI 1.48-6.59) were found to increase the risk of childhood ALL, while GSTM1 did not alter the risk. Meta-analysis included 22, 10 and 20 studies examining the association of childhood ALL with GSTM1, GSTP1 and GSTT1 genotypes, respectively. Only GSTM1 genotype (OR 1.29, 95%CI 1.10-1.62) was associated with increased risk in the overall analysis. However, both GSTM1 (OR 1.54, 95%CI 1.12-2.10) and GSTT1 (OR 1.63, 95%CI 1.32-1.99) null genotypes were associated with increased risk in Asian subjects. The risk of developing childhood ALL was not associated with GSTP1 genotype.

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Are genotypes of glutathione S-transferase superfamily a risk factor for childhood acute lymphoblastic leukemia? Results of an Italian case–control study

Cited by 9 publications

References 9 publications

The GSTP1 A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia: results from an updated meta-analysis

The GSTP1 A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia: results from an updated meta-analysis

Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis

Glutathione-S-transferase polymorphism and acute lymphoblastic leukemia (ALL) in north Indian children: a case–control study and meta-analysis

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