Are Kupffer cells involved in the metabolic adaptation of the liver to dietary carbohydrates given after fasting?

Neyrinck, Audrey M.; Wispelaere, L D De; Vanhulle, Valérie P.; Taper, Henryk

doi:10.1016/s0304-4165(00)00070-2

Cited by 7 publications

(1 citation statement)

References 35 publications

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“…The mammalian liver is a morphologically and functionally complex organ, made up not only of the largely predominant parenchymal cells (hepatocytes), but also non-parenchymal cells (N-PCs), including Ito, Kupffer and sinusoidal endothelial cells (SECs), as well as other cell types that reside in the sinusoidal compartment [1][2][3]. Although present in a small percentage in the total liver volume (around 6%), non-parenchymal cells play an important role in the regulation of many hepatocyte functions [1,4] as well as in the immunobiology of the liver [5], in both normal and pathological conditions [6]. Hepatic stellate cells (HSCs) also called Ito cells, fat-storing cells, lipocytes [7], are vitamin A-storing cells located in the space of Disse between hepatocytes and sinusoidal endothelial cells, which is why they are also called perisinusoidal cells.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Aspects of Ito and Kupffer Cells in the Liver of Domesticated and Wild Ruminants

Carollo

Giancamillo²,

Vitari

et al. 2012

OJVM

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The mammalian liver is a morphologically and functionally complex organ, made up of not only of the largely predominant parenchymal cells (hepatocytes) but also non-parenchymal cells. Although there are less non-parenchymal cells than hepatocytes, they nevertheless play an important role in regulating many hepatocyte functions, as well as in the immunology of the liver. We investigated the structural aspects of the liver and the morpho-functional characteristics of Ito and Kupffer cells in two domesticated ruminant species (cattle and goat) in comparison with four wild ruminant species living in captivity in a zoo in northern Italy. The liver specimens were studied using histological, histochemical and immunohistochemical methods. The liver parenchyma was structurally normal. Immunohistochemistry was performed for desmin, glial fibrillary acidic protein (GFAP), vimentin, α-smooth muscle actin (α-SMA), collagen I, lysozyme, CD 68 and tumor necrosis factor α (TNF-α). In all the studied ruminants, Ito cells reacted with desmin and vimentin antibodies, Kupffer cells were evidenced only with lysozyme-immunopositivity, and both displayed a characteristic distribution in the hepatic lobular/acinar structure. The results obtained, not only contribute to the knowledge of ruminant wild species, but also help to define a normal structure reference for the diagnosis and treatment of liver diseases.

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Section: Introductionmentioning

confidence: 99%

Immunohistochemical Aspects of Ito and Kupffer Cells in the Liver of Domesticated and Wild Ruminants

Carollo

Giancamillo²,

Vitari

et al. 2012

OJVM

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Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor α expression by releasing cytokines

Fang

Zou

Zhao³

et al. 2012

Arch Toxicol

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Kupffer cells (KCs) have been demonstrated to play a role in the regulation of intra-hepatic lipid metabolism through the synthesis and secretion of biologically active products. The involvement of KCs in the disturbance of lipid metabolism that induced by perfluorononanoic acid (PFNA), a known agonist of the peroxisome proliferator-activated receptor alpha (PPARα), was investigated in this study. Rats were exposed to PFNA or PFNA combined with gadolinium chloride, an inhibitor of KCs, for 14 days. PFNA exposure dose-dependently increased absolute and relative liver weights, induced triglyceride accumulation, up-regulated the expression of both SERBP-1c and PPARα, and stimulated the release of TNFα and IL-1β. Inactivation of KCs markedly lowered TNFα and IL-1β level, enhanced PFNA-induced expression of PPARα and its target genes, and reduced liver triglyceride levels. In vitro, PFNA-induced expression of PPARα in primary cultured hepatocytes was suppressed by recombinant rat TNFα and IL-1β. However, inhibition of the NF-κB pathway prevented this. Transient transfection and promoter analysis further revealed that these two cytokines and NF-κB were coordinately involved in the suppression of PPARα promoter activity. Our data demonstrate that TNFα and IL-1β released from KCs following PFNA exposure can suppress the expression of PPARα via NF-κB pathway, which partially contribute to the evident accumulation of triglycerides in rat liver.

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Critical role of Kupffer cells in the management of diet-induced diabetes and obesity

Neyrinck¹,

Cani²,

Dewulf³

et al. 2009

Biochemical and Biophysical Research Communications

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Are Kupffer cells involved in the metabolic adaptation of the liver to dietary carbohydrates given after fasting?

Cited by 7 publications

References 35 publications

Immunohistochemical Aspects of Ito and Kupffer Cells in the Liver of Domesticated and Wild Ruminants

Immunohistochemical Aspects of Ito and Kupffer Cells in the Liver of Domesticated and Wild Ruminants

Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor α expression by releasing cytokines

Critical role of Kupffer cells in the management of diet-induced diabetes and obesity

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