Are patient demographics different for early-onset and late-onset Blount disease? Results based on meta-analysis

Abstract

Early-onset and late-onset Blount disease has been described with some clinical overlap between the two forms. Using PRISMA guidelines, we searched for articles that included demographics of patients with both types of Blount disease. On the basis of 24 articles that met our inclusion criteria, patients with early-onset Blount disease were more likely to have bilateral involvement [odds ratio (OR) 4.30, 95% confidence interval (CI) 2.27-8.17] and less likely to be Black (OR 0.20, 95% CI 0.08-0.53) or male (OR 0.32, 95% CI 0.13-0.78). Our results confirm that differences based on laterality, race, and sex exist between the two forms of Blount disease.

Body mass index and Blount's disease: a single academic hospital experience

“…1,2,9,10 A number of studies show a strong correlation between Blount's disease and obesity. 3,[10][11][12][13][14] Lisenda et al found no independent association between vitamin D deficiency and Blount's disease in their study in South African children. 15 Obesity has been shown to greatly increase the medial compartment pressure and contribute to the development of Blount's disease by the Heuter-Volkmann principle.…”

“…1,2 Blount's disease is classified into early-onset (infantile) and late-onset based on whether the limb deformity develops before or after the age of four years. [2][3][4] It is classified radiologically by Langenskiold into six progressive stages per severity of the deformity to help in prognosticating patients' outcome. [4][5][6][7] The incidence of Blount's disease in South Africa was estimated to be 0.03% three decades ago.…”

“…8 The aetiology of Blount's disease remains unknown, though multifactorial origin is proposed with genetic and mechanical components contributing to its development. 3 There is a predisposition of black children to develop Blount's disease compared to other racial groups. 3 Blount's disease has been linked to increasing weight and vitamin D deficiency.…”

“…3 There is a predisposition of black children to develop Blount's disease compared to other racial groups. 3 Blount's disease has been linked to increasing weight and vitamin D deficiency. 1,2,9,10 A number of studies show a strong correlation between Blount's disease and obesity.…”

Treatment of Patients With Early Stages of Infantile Blount`s Disease

“…С учетом клинико-рентгенологических характеристик, с нашей точки зрения, выделение двух основных форм -инфантильной и подростковой -является наиболее целесообразным. Для инфантильной формы в большей степени характерны двустороннее поражение, более выраженная степень деформации, преобладание пациентов женского пола [14].…”