Argan oil ameliorates sodium fluoride–induced renal damage via inhibiting oxidative damage, inflammation, and intermediate filament protein expression in male rats

Saber, Taghred M.; Mansour, M.; Shaban, Ahmed; Mohamed, Rasha M.S.M.; Fouad, Rania A; Arisha, Ahmed Hamed

doi:10.1007/s11356-020-09366-z

Cited by 15 publications

(8 citation statements)

References 46 publications

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“…Moreover, AO exerted nephroprotective effects manifested by the reduction of the elevated urea and creatinine levels and improvement of the renal architecture. Consistent with previous studies, AO improved the kidney function biomarkers following exposure to hydrogen peroxide [ 55 ], lead [ 56 ], and Na-fluoride [ 22 ] toxicity. These protective effects of AO against BM-induced nephrotoxicity may be closely related to its powerful antioxidant effect evidenced by the decrease of MDA and NO levels and the increase of GSH content in renal tissue recorded in this study and previous studies [ 20 , 22 , 57 ].…”

Section: Discussionsupporting

confidence: 90%

“…Consistent with previous studies, AO improved the kidney function biomarkers following exposure to hydrogen peroxide [ 55 ], lead [ 56 ], and Na-fluoride [ 22 ] toxicity. These protective effects of AO against BM-induced nephrotoxicity may be closely related to its powerful antioxidant effect evidenced by the decrease of MDA and NO levels and the increase of GSH content in renal tissue recorded in this study and previous studies [ 20 , 22 , 57 ]. The antioxidant properties are obviously due to its content of bioactive molecules and antioxidants such as vanillic acid caffeic acid, ferulic acid, resorcinol, catechin, phenolic compounds, coenzyme Q10, and melatonin [ 16 , 17 , 55 ].…”

Section: Discussionsupporting

confidence: 90%

“…Interestingly, AO has therapeutic value in cardiovascular disorders associated with obesity, hypertension, and insulin resistance [ 16 ]. Moreover, previous literature confirmed the antioxidant, anti-inflammatory, anti-mutagenic, and anti-carcinogenic activities of AO [ 19 , 20 ], as well as its neuro- and hepatorenal protective effects [ 19 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 78%

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The Antioxidant, Anti-Apoptotic, and Proliferative Potency of Argan Oil against Betamethasone-Induced Oxidative Renal Damage in Rats

Orabi

Allam

Shawky

et al. 2020

Biology

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The present study aimed to investigate the protective effect of argan oil (AO) against nephrotoxic effects following overdose and long-term administration of betamethasone (BM). The phytochemical compositions of AO were assessed using GC/MS. Forty eight male Wister albino rats were divided into six groups and treated for 3 successive weeks. The control group was orally administrated distilled water daily, the BM group received BM (1 mg/kg, IM, day after day), AO/0.5 and AO/1 groups received AO (0.5 mL/kg, 1 mL/kg, orally, daily, respectively), BM + AO/0.5 group and BM + AO/1 group. The results revealed that BM induced hematological changes, including reduction of red blood cells with leukocytosis, neutrophilia, monocytosis, lymphocytopenia, and thrombocytopenia. Moreover, BM caused a significant increase of serum urea and creatinine levels, and renal malondialdehyde and nitric oxide contents with significant decrease of reduced glutathione content. BM also caused vascular, degenerative, and inflammatory histopathological alterations in kidney, along with an increase in the Bax/Bcl-2 ratio, activation of caspase-3, and decrease of proliferating cell nuclear antigen expression. Conversely, the concomitant administration of AO (0.5, 1 mL/kg) with BM ameliorated the aforementioned hematological, biochemical, pathological, and histochemical BM adverse effects. In conclusion, AO has protective effects against BM-induced renal damage, possibly via its antioxidant, anti-apoptotic, and proliferative properties.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 78%

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The Antioxidant, Anti-Apoptotic, and Proliferative Potency of Argan Oil against Betamethasone-Induced Oxidative Renal Damage in Rats

Orabi

Allam

Shawky

et al. 2020

Biology

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“…The serum levels of blood urea nitrogen (BUN), creatinine and serum determination of Tumor Necrosis Factor alpha (TNF-α) concentration were performed as previously reported (Saber et al, 2020).…”

Section: Biochemical Measurementsmentioning

confidence: 99%

“…Total RNA extraction was performed as previously described (Abu Zeid et al, 2021;Khamis et al, 2020;Mansour et al, 2020). For mRNA, 500 ng of that total RNA was reversetranscribed as previously described (Arisha and Moustafa, 2019;Hussein et al, 2020), while for miRNA, 10 ng were reverse-transcribed using the TaqMan™ Small RNA Assays (ThermoFisher Scientific, Waltham, MA, USA) following manufacturer instructions.…”

Section: Real Time Rt-pcrmentioning

confidence: 99%

Dox Capsulated Chitosan Nanoparticles Effect as Anti-Carcinogenic Therapeutic Agent in Mice with Ehrlich Carcinoma

Khater¹,

Ezz-eldin²,

Saad³

et al. 2020

JAHP

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C ancer poses a significant threat to human life and health, and has been a leading cause of death in humans in recent years (Stewart and Wild, 2014). In the past half century, chemotherapy has greatly strengthened the treatment for cancer. Unfortunately, traditional chemotherapeutic agents lack selectivity in which tumor cells take up less than 0.1-1 % of the drugs, and the other 99% developing into healthy tissue (van der Veldt et al., 2010).The development of drug delivery systems that are successful and have therapeutic selectivity is therefore one of the main challenges facing chemotherapy today.The nanoparticle drug delivery system (NDDS) has recently gained significant interest and has evolved rapidly (Wohlfart et al., 2011). Such a drug delivery system has been engineered to achieve a higher partial drug concentration, reduce systemic toxicity, and maintain drug release. Nanoparticles can penetrate tumors by passive targeting research Article Abstract | Drug delivery systems including nanoparticles are used to enhance anticancer drugs therapeutic and pharmacological properties. A biodegradable polymer chitosan (CS) was used in this study for Doxorubicin (DOX) delivery. In Ehrlich ascites carcinoma (EAC) tumor, anticancer activity of these nanoparticles was investigated in-vivo. EAC bearing mice treated with free DOX revealed significantly increase in the levels of blood urea nitrogen (BUN) and creatinine compared with EAC bearing mice group. At the same time, the levels of BUN, creatinine and TNF-α in EAC bearing mice treated with doxorubicin capsulated chitosan nanoparticles (DOX-CNs) at dose (1-3 mg/kg) revealed significant declines when compared with EAC bearing mice treated with free DOX. The expression levels of miR-34a was found to be significantly up-regulated in DOX-treated mice accompanied by non-significantly change in the mRNA expression of renal Sirt1 compared with EAC-bearing mice group. The levels of miR-122 were nonsignificantly changed in renal tissue of EAC bearing mice given free DOX accompanied by significantly up-regulation in the expression levels of renal FOXO3 gene compared to EAC bearing mice and negative control groups. On the other hand, these levels were reversed in DOX capsulated chitosan nanoparticles treatment at dose (1mg/kg) but not at dose (2 or 3 mg/kg). The study reported the safety of administering DOX capsulated chitosan nanoparticles at dose (1mg/kg) and elicited anti-carcinogenic activity as compared with DOX itself.

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Dietary exposure to methyl mercury chloride induces alterations in hematology, biochemical parameters, and mRNA expression of antioxidant enzymes and metallothionein in Nile tilapia

Alam

Zeid

Khalifa

et al. 2021

Environ Sci Pollut Res

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Argan oil ameliorates sodium fluoride–induced renal damage via inhibiting oxidative damage, inflammation, and intermediate filament protein expression in male rats

Cited by 15 publications

References 46 publications

The Antioxidant, Anti-Apoptotic, and Proliferative Potency of Argan Oil against Betamethasone-Induced Oxidative Renal Damage in Rats

The Antioxidant, Anti-Apoptotic, and Proliferative Potency of Argan Oil against Betamethasone-Induced Oxidative Renal Damage in Rats

Dox Capsulated Chitosan Nanoparticles Effect as Anti-Carcinogenic Therapeutic Agent in Mice with Ehrlich Carcinoma

Dietary exposure to methyl mercury chloride induces alterations in hematology, biochemical parameters, and mRNA expression of antioxidant enzymes and metallothionein in Nile tilapia

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