Arsenic and antimony co-induced nephrotoxicity via autophagy and pyroptosis through ROS-mediated pathway in vivo and in vitro

Wan, Fang; Zhong, Gaolong; Wu, Shaofeng; Jiang, Xingshan; Liao, Jianzhao; Zhang, Xiaoyong; Zhang, Hui; Mehmood, Khalid; Tang, Zhaoxin; Hu, Lianmei

doi:10.1016/j.ecoenv.2021.112442

Cited by 39 publications

(19 citation statements)

References 43 publications

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“…This result was consistent with the results of previous studies [ 21 , 22 ]. Antimony is a common environmental pollutant that is widely present in the natural environment, and antimony exposure can induce histopathological changes in the kidney [ 21 – 23 ]. Whereas epidemiological data on the effects of barium on human health are scarce, the risk of exposure to barium is higher in non-occupational populations, who are exposed mainly through drinking water and food [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study

Cao

et al. 2022

BMC Nephrol

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Background Kidney stones have become a worldwide public health problem. The purpose of this research is to study the relationship between plasma cadmium level and the prevalence of kidney stones in an adult population. Methods The data of this study were based on a current survey conducted from December 2018 to November 2019 in Gongcheng Yao Autonomous County, Guangxi, China. A total of 940 study subjects of the same sex and age (within 2 years of each other) according to 1:1 matching were selected for a case–control study. The diagnosis of kidney stones was based on the presence of strong light spots, patches, clusters, or bands within the renal sinus region, followed by an echo-free bundle of acoustic images. Plasma metal elements were determined by the metal plasma method. The relationship between plasma cadmium concentration and the prevalence of kidney stones was assessed using logistic regression and restricted cubic spline regression. Results The crude ratio for kidney stones in the highest quartile of plasma cadmium was 1.164 (95% CI, 1.121 to 2.324) compared with the lowest quartile. A positive correlation was found between the two (P for trend = 0.039). After adjusting for potential confounders, the ratio of plasma cadmium to kidney stones in the highest quartile was 1.606 (95% CI, 1.100 to 2.344) compared with the lowest quartile, and the findings remained unchanged. Conclusion The odds of kidney stones in adults increased with increasing plasma cadmium exposure, and high plasma cadmium may be a risk factor for kidney stones.

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Section: Discussionmentioning

confidence: 99%

Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study

Cao

et al. 2022

BMC Nephrol

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“…A decrease in RCC Ι activity was also observed, which was the most important source of ROS. Mounting evidence has shown that ROS is one of the critical signal molecules of autophagy and pyroptosis 17,48–50 . Thus, NAC was used to partially scavenge ROS, and the results showed that ROS downregulation not only inhibited CRIZO‐triggered pyroptosis by preventing NF‐kB activation but also reduced autophagic flux via mTOR activation.…”

Section: Discussionmentioning

confidence: 99%

“…Mounting evidence has shown that ROS is one of the critical signal molecules of autophagy and pyroptosis. 17 , 48 , 49 , 50 Thus, NAC was used to partially scavenge ROS, and the results showed that ROS downregulation not only inhibited CRIZO‐triggered pyroptosis by preventing NF‐kB activation but also reduced autophagic flux via mTOR activation. This implies that CRIZO damaged the mitochondria leading to increased ROS level, which induced pyroptosis and autophagy to cause hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

MgIG exerts therapeutic effects on crizotinib‐induced hepatotoxicity by limiting ROS‐mediated autophagy and pyroptosis

Wang

et al. 2022

J Cellular Molecular Medi

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Crizotinib (CRIZO) has been widely employed to treat non‐small‐cell lung cancer. However, hepatic inflammatory injury is the major toxicity of CRIZO, which limits its clinical application, and the underlying mechanism of CRIZO‐induced hepatotoxicity has not been fully explored. Herein, we used cell counting kit‐8 assay and flow cytometry to detect CRIZO‐induced cytotoxicity on human hepatocytes (HL‐7702). CRIZO significantly reduced the survival rate of hepatocytes in a dose‐dependent manner. Furthermore, the reactive oxygen species (ROS) assay kit showed that CRIZO treatment strongly increased the level of ROS. In addition, CRIZO treatment caused the appearance of balloon‐like bubbles and autophagosomes in HL‐7702 cells. Subsequently, Western blotting, quantitative real‐time PCR and ELISA assays revealed that ROS‐mediated pyroptosis and autophagy contributed to CRIZO‐induced hepatic injury. Based on the role of ROS in CRIZO‐induced hepatotoxicity, magnesium isoglycyrrhizinate (MgIG) was used as an intervention drug. MgIG activated the Nrf2/HO‐1 signalling pathway and reduced ROS level. Additionally, MgIG suppressed hepatic inflammation by inhibiting NF‐κB activity, thereby reducing CRIZO‐induced hepatotoxicity. In conclusion, CRIZO promoted autophagy activation and pyroptosis via the accumulation of ROS in HL‐7702 cells. MgIG exerts therapeutic effects on CRIZO‐induced hepatotoxicity by decreasing the level of ROS.

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“…In addition, Autophagy and pyroptosis promote each other in HL-7702 cells [ 91 ]. ROS has been involved in autophagy and pyroptosis [ 92 ]. In the above study, BaP increased ROS level and induced autophagic cell death and pyroptosis in HL-7702 cells, ROS may mediate the positive relationship between autophagy and pyroptosis.…”

Section: The Role Of Autophagy and Pyroptosis In Liver Disordersmentioning

confidence: 99%

The Role of Autophagy and Pyroptosis in Liver Disorders

Zhao

Liu

Yang

et al. 2022

IJMS

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Pyroptosis is a programmed cell death caused by inflammasomes, which can detect cell cytosolic contamination or disturbance. In pyroptosis, caspase-1 or caspase-11/4/5 is activated, cleaving gasdermin D to separate its N-terminal pore-forming domain (PFD). The oligomerization of PFD forms macropores in the membrane, resulting in swelling and membrane rupture. According to the different mechanisms, pyroptosis can be divided into three types: canonical pathway-mediated pyroptosis, non-canonical pathway-mediated pyroptosis, and caspase-3-induced pyroptosis. Pyroptosis has been reported to play an important role in many tissues and organs, including the liver. Autophagy is a highly conserved process of the eukaryotic cell cycle. It plays an important role in cell survival and maintenance by degrading organelles, proteins and macromolecules in the cytoplasm. Therefore, the dysfunction of this process is involved in a variety of pathological processes. In recent years, autophagy and pyroptosis and their interactions have been proven to play an important role in various physiological and pathological processes, and have gradually attracted more and more attention to become a research hotspot. Therefore, this review summarized the role of autophagy and pyroptosis in liver disorders, and analyzed the related mechanism to provide a basis for future research.

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Arsenic and antimony co-induced nephrotoxicity via autophagy and pyroptosis through ROS-mediated pathway in vivo and in vitro

Cited by 39 publications

References 43 publications

Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study

Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study

MgIG exerts therapeutic effects on crizotinib‐induced hepatotoxicity by limiting ROS‐mediated autophagy and pyroptosis

The Role of Autophagy and Pyroptosis in Liver Disorders

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