Arsenic concentrations, diversity and co-occurrence patterns of bacterial and fungal communities in the feces of mice under sub-chronic arsenic exposure through food

Wang, Jiating; Hu, Wei; Yang, Huilin; Chen, Fubin; Shu, Yan-Wen; Zhang, Guiwei; Liu, Jizhen; Liu, Yungang; Li, Huawen; Guo, Lianxian

doi:10.1016/j.envint.2020.105600

Cited by 46 publications

(9 citation statements)

References 89 publications

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“…Arsenic (As) is known as a global concern that the main route of exposure to this metalloid is through food and water [ 1 ]. As influences every organ and tissue in the human body such as the cardiovascular, respiratory, gastrointestinal, productive, and nervous systems [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Zadeh

Esmaeilpour

Aminzadeh

et al. 2021

BioMed Research International

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Arsenic (As) toxicity has deleterious effects on human health causing disorder in the brain. The aim of this study was to investigate the possible neuroprotective effect of resveratrol (RSV) on arsenic-induced neurotoxicity in rats. Neurotoxicity in rats was developed by treating As 10 mg/kg/day for 21 days orally. Animals were put into seven groups: control, vehicle, As, As+RSV10, As+RSV20 mg/kg, RSV10, and RSV20 mg/kg. Behavioral assessments such as the social interaction test, novel object recognition test, elevated plus maze, open field, the Morris water maze, in addition to assessment of biomarkers such as ferric reducing ability of plasma assay, glutathione assay, and malondialdehyde assay, were used to evaluate the effects of RSV on cognitive impairment and molecular changes induced by As. The results showed that cognitive performance impaired in As rats. RSV20 mg/kg significantly could ameliorate behavioral changes like spatial learning in days 3 and 4 ( p < 0.05 ), recognition learning and memory ( p < 0.01 ), disabilities in motor coordination and stress ( p < 0.05 ), increased anxiety ( p < 0.05 ), and social interaction deficit (sociability ( p < 0.001 ) and social memory ( p < 0.05 )). RSV20 mg/kg also attenuated molecular modifications like decreased antioxidant power ( p < 0.001 ), reduced glutathione content ( p < 0.05 ), and increased malondialdehyde level ( p < 0.05 ) induced by As. In addition to oxidative stress assessments, RSV10 mg/kg could significantly increase FRAP ( p < 0.01 ) and GSH ( p < 0.05 ); however, MDA was not significantly increased. Our current behavioral findings suggest that RSV has neuroprotective effects against AS toxicity.

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Section: Introductionmentioning

confidence: 99%

Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Zadeh

Esmaeilpour

Aminzadeh

et al. 2021

BioMed Research International

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“…According to the literature, arsenic is excreted in large amounts in the urine and feces and rarely remains in the blood. , However, dimethylarsenic acid was still found in serum by UPLC-MS/MS metabolomic tests Figure shows that with the increase of arsenic concentration and the extension of exposure time, the content of dimethylarsenic acid in serum was increased significantly.…”

Section: Resultsmentioning

confidence: 99%

Metabolomics Analysis of Chronic Exposure to Dimethylarsenic Acid in Mice and Toxicity Assessment of Organic Arsenic in Food

et al. 2022

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Dimethylarsenic acid is a natural organic arsenic in seafood and one of the important metabolites of inorganic arsenic, which is generally considered to have low or no toxicity. However, due to the controversy of the toxicity of organic arsenic, the food safety standard of organic arsenic has not been established until now, and the effects of organic arsenic on chronic toxicity and the overall metabolic level of animals are rarely reported. In our study, 64 female C57BL/6 mice were exposed to different concentrations of dimethylarsenic acid with water intake. Fifteen metabolites in serum were detected to be altered with the increase of arsenic concentration and exposure time. Dimethylarsenic acid exposure significantly affected the overall metabolic level of mice, and the related effects were not recovered shortly after the suspension of arsenic intake. Although arsenic was excreted largely in urine and feces, continued dimethylarsenic acid exposure could still lead to arsenic accumulation in the liver and kidneys and cause mild nephritis in mice.

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“…The metabolism, mainly referring to reduction and biomethylation of As, mainly happens in the liver. 35 Therefore, the speciation of As was investigated using the liver tissues. mixture were As(III) and DMA (5.15 ± 0.8 ng/g and 1.74 ± 0.36 ng/g, respectively; accounting for 9.9% and 3.3% of tAs respectively).…”

Section: Altered Metabolism Of As(ⅲ) By Co-exposure With Ceo 2 Npsmentioning

confidence: 99%

Interactions between cerium dioxide nanoparticles and arsenite change their biological fate in the gastrointestinal tract of mice

Huang

Lum

et al. 2023

Environ. Sci.: Nano

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Arsenic concentrations, diversity and co-occurrence patterns of bacterial and fungal communities in the feces of mice under sub-chronic arsenic exposure through food

Cited by 46 publications

References 89 publications

Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Metabolomics Analysis of Chronic Exposure to Dimethylarsenic Acid in Mice and Toxicity Assessment of Organic Arsenic in Food

Interactions between cerium dioxide nanoparticles and arsenite change their biological fate in the gastrointestinal tract of mice

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