Arterial Pressure Monitoring in Mice

Zhao, Xin; Ho, David; Gao, Shumin; Hong, Chull; Vatner, Dorothy E.; Vatner, Stephen F.

doi:10.1002/9780470942390.mo100149

Cited by 75 publications

(72 citation statements)

References 27 publications

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“…Higher blood flow to the caudal artery leads to higher viscous losses, resulting in a decrease of the mean blood pressure in the tail. As mice regulate the blood flow in the tail during thermoregulation, especially during anesthesia, these results confirm earlier findings that tail-cuff blood pressure measurements in anesthetized mice are to be interpreted with caution (Gordon, 1993;Zhao et al, 2011). curate and trustworthy value for central aortic compliance.…”

Section: Discussionsupporting

confidence: 87%

A 1D model of the arterial circulation in mice

Aslanidou

Trachet

Reymond

et al. 2016

ALTEX

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SummaryAt a time of growing concern over the ethics of animal experimentation, mouse models are still an indispensable source of insight into the cardiovascular system and its most frequent pathologies. Nevertheless, reference data on the murine cardiovascular anatomy and physiology are lacking. In this work, we developed and validated an in silico, one dimensional model of the murine systemic arterial tree consisting of 85 arterial segments. Detailed aortic dimensions were obtained in vivo from contrast-enhanced micro-computed tomography in 3 male, C57BL/6J anesthetized mice and 3 male ApoE -/-mice, all 12-weeks old. Physiological input data were gathered from a wide range of literature data. The integrated form of the Navier-Stokes equations was solved numerically to yield pressures and flows throughout the arterial network. The resulting model predictions have been validated against invasive pressure waveforms and noninvasive velocity and diameter waveforms that were measured in vivo on an independent set of 47 mice. In conclusion, we present a validated one-dimensional model of the anesthetized murine cardiovascular system that can serve as a versatile tool in the field of preclinical cardiovascular research.

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Section: Discussionsupporting

confidence: 87%

A 1D model of the arterial circulation in mice

Aslanidou

Trachet

Reymond

et al. 2016

ALTEX

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“…The MAP and heart rate did not change with age. Thus the prior results measured by tail cuff (41), which can increase heart rate and MAP (13,26,55), match our data during physical activity, and our analysis demonstrates a significant genotype ϫ activity interaction. A model to explain these results is that a primary reduction in heart rate in Brs3 Ϫ/y mice elicits compensatory mechanisms to defend blood pressure, presumably including the intact baroreceptor reflex.…”

Section: Discussionsupporting

confidence: 88%

Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism

Lateef

Xiao

Brychta

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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Lateef DM, Xiao C, Brychta RJ, Diedrich A, Schnermann J, Reitman ML. Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism. Am J Physiol Heart Circ Physiol 310: H891-H898, 2016. First published January 22, 2016; doi:10.1152/ajpheart.00963.2015.-Bombesin-like receptor 3 (BRS-3) is an orphan G protein-coupled receptor that regulates energy expenditure, food intake, and body weight. We examined the effects of BRS-3 deletion and activation on blood pressure and heart rate. In free-living, telemetered Brs3 null mice the resting heart rate was 10% lower than wild-type controls, while the resting mean arterial pressure was unchanged. During physical activity, the heart rate and blood pressure increased more in Brs3 null mice, reaching a similar heart rate and higher mean arterial pressure than control mice. When sympathetic input was blocked with propranolol, the heart rate of Brs3 null mice was unchanged, while the heart rate in control mice was reduced to the level of the null mice. The intrinsic heart rate, measured after both sympathetic and parasympathetic blockade, was similar in Brs3 null and control mice. Intravenous infusion of the BRS-3 agonist MK-5046 increased mean arterial pressure and heart rate in wild-type but not in Brs3 null mice, and this increase was blocked by pretreatment with clonidine, a sympatholytic, centrally acting ␣ 2-adrenergic agonist. In anesthetized mice, hypothalamic infusion of MK-5046 also increased both mean arterial pressure and heart rate. Taken together, these data demonstrate that BRS-3 contributes to resting cardiac sympathetic tone, but is not required for activity-induced increases in heart rate and blood pressure. The data suggest that BRS-3 activation increases heart rate and blood pressure via a central sympathetic mechanism.bombesin-like receptor 3; blood pressure; heart rate; sympathetic nervous system; energy metabolism NEW & NOTEWORTHY MK-5046, a bombesin-like receptor 3 (BRS-3) agonist, increases heart rate and blood pressure via increased central sympathetic tone. Brs3 null mice have a reduced resting heart rate that increases disproportionately with physical activity. BRS-3 contributes to the central regulation of heart rate and blood pressure.OBESITY is strongly associated with cardiovascular risk factors, including hypertension (6). However, the mechanisms linking obesity and hypertension are not fully understood (7,44). A number of neuroendocrine systems controlling energy homeostasis also regulate blood pressure and heart rate, including leptin, the melanocortin system, and ghrelin (12, 36, 45, 48 -50). The genetic and pharmacological manipulations of these systems that reduce adiposity generally also increase blood pressure, which is undesirable in a treatment for obesity.Bombesin-like receptor 3 (BRS-3) is a G protein-coupled receptor for which the endogenous ligand is unidentified (4,21,29,33). Despite the name, BRS-3 has a low affinity for bombesin and the related molecules, neuromedin B and gastrin-releasing ...

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“…We will now review the methods for blood pressure measurement in rodents with an emphasis on the most commonly used technique, the indirect tail-cuff method, and the state-of the art non-invasive telemetric method. Again, the interested readers will be directed to the review by Kurtz et al (2005), Zhao et al (2011) or Feng & DiPetrillo (2009 for details and information on other methods. Ruban D. Buñag started his 1983 review of blood pressure measurement techniques in rats by «A rat's tail is a slender appendage on which the weight of so much research in hypertension hangs, yet blood pressure measurements recorded from it are usually taken for granted, often abused, but seldom discussed» (Buñag RD, 1983).…”

Section: Blood Pressure Measurement In Mouse and Ratmentioning

confidence: 99%