Arterial stiffness is associated with left atrial size in hypertensive patients

Lantelme, Pierre; Laurent, Stéphane; Besnard, Cyril; Bricca, Giampiero; Vincent, Madeleine; Legedz, Liliana; Milon, H

doi:10.1016/s1875-2136(08)70253-5

Cited by 69 publications

(59 citation statements)

References 32 publications

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“…In the present case, transthoracic echocardiography was used to evaluate the cardiac source of emboli, and showed left ventricular diastolic dysfunction. Recent reports have revealed that LVDD is a risk factor for ischemic stroke [6,7]. Although the mechanisms of the association between LVDD and ischemic stroke remain unclear, there are some tentative explanations in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…The first explanation suggests that LVDD may be caused by existing latent heart failure and/or silent myocardial ischemia [8]. In a second possible evaluation, Lantelme et al [7] reported that left ventricular diastolic dysfunction may lead to left atrial dilatation with subsequent risk of atrial fibrillation (AF) and cerebral embolism. Therefore, we speculated that, in our case, LVDD might be a cause of the bilateral caudate infarcts as induced by atrial dilatation or latent heart failure or silent myocardial ischemia.…”

Section: Discussionmentioning

confidence: 99%

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Bilateral caudate nucleus infarction resulting from left ventricular diastolic dysfunction

Varoğlu

2010

Open Medicine

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AbstractBilateral caudate infarct is a very rare neurological situation, usually caused by small-artery disease resulting from a cardiac embolism. The most prominent clinical features of caudate vascular lesions are behavioral and cognitive abnormalities. We report here a case of bilateral infarction of the caudate nucleus and right parietal lobe with loss of consciousness and left hemiparesia resulting from left ventricular diastolic dysfunction (LVDD). A 50-year-old woman was admitted to our clinic with symptoms of mental status change. One day ago before appearing at our clinic, the patient was hospitalized because of food intoxication and diarrhea. Her neurological examination revealed that orientation-cooperation was impaired, and motor weakness was found in the left extremities, predominantly in the upper limb. The lesions detected by CT and MRI were located on the bilateral caudate nucleus and right parietal lobe. Transthoracic echocardiography revealed LVDD. Therefore, the patient was diagnosed as having had an ischemic stroke. Three days after the treatment, all neurological deficits had improved and the patient was discharged. Attending physicians should be alert to the presence of permanent or intermittent complications of LVDD in patients with ischemic cerebral events, especially in patients with the bilateral caudate nucleus infarcts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bilateral caudate nucleus infarction resulting from left ventricular diastolic dysfunction

Varoğlu

2010

Open Medicine

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confidence: 99%

“…Left ventricular (LV) remodeling is a powerful determinant of left atrial (LA) size, therefore arterial stiffness could influence LA dimensions, as well (5,6,12). Arterial stiffness was found to be associated with LA size in different patient populations (12). Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be an optimal choice for non-invasive quantification of LV and LA volumes and deformation parameters by 3D volumetric and strain analysis (1,4,7,8,11,13,15,(17)(18)(19)22).…”

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confidence: 99%

Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects – Results from the MAGYAR-Healthy Study

Nemes

Piros

Domsik

et al. 2015

Acta Physiologica Hungarica

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Left atrial (LA) distension has been demonstrated to be linked with aortic stiffness in different patient populations. Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be a promising tool for volumetric and functional evaluation of the LA. The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects. The study included 19 healthy volunteers (mean age: 37.9 ± 11.4 years, 11 men) who had undergone complete two-dimensional (2D) Doppler transthoracic echocardiography extended with the assessment of aortic elastic properties and 3DSTE. Results: None of LA volumes correlated with echocardiographic aortic elastic properties. Active atrial stroke volume correlated with aortic stiffness index (ASI, r = 0.45, p = 0.05). None of other volume-based functional properties significantly correlated with aortic stiffness parameters. Global peak 3D strain correlated with aortic strain (r = -0.46, p = 0.05). Global radial pre-atrial contraction strain correlated with ASI (r = -0.49, p = 0.04) and AS (r = -0.50, p = 0.04). Conclusions:Correlations exist between 3DSTE-derived LA functional parameters and eschocardiographic aortic elastic properties in healthy subjects.Keywords: aortic, distensibility, echocardiography, function, left atrium, speckle-tracking, stiffness, threedimensionalThere is a strong interplay between vascular and cardiac mechanics including arterialventricular coupling. Left ventricular (LV) remodeling is a powerful determinant of left atrial (LA) size, therefore arterial stiffness could influence LA dimensions, as well (5, 6, 12). Arterial stiffness was found to be associated with LA size in different patient populations (12). Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be an optimal choice for non-invasive quantification of LV and LA volumes and deformation parameters by 3D volumetric and strain analysis (1,4,7,8,11,13,15,(17)(18)(19)22). The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects.

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“…LV remodeling is a powerful determinant of LA size, therefore arterial stiffness could influence LA dimensions, as well (15)(16)(17). Arterial stiffness was found to be associated with LA size in different patient populations (17).…”

Section: Introductionmentioning

confidence: 99%

Focus on atrial function: benefits of three-dimensional speckle-tracking echocardiography

Piros¹

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Arterial stiffness is associated with left atrial size in hypertensive patients

Abstract: These results led us to propose AF as a new possible pathophysiological link between arterial stiffness and stroke. These results also emphasize the cardiac consequences of arterial stiffness which can fuel a new approach to AF prevention.

Cited by 69 publications

References 32 publications

Bilateral caudate nucleus infarction resulting from left ventricular diastolic dysfunction

Bilateral caudate nucleus infarction resulting from left ventricular diastolic dysfunction

Correlations between three-dimensional speckle-tracking echocardiography-derived left atrial functional parameters and aortic stiffness in healthy subjects – Results from the MAGYAR-Healthy Study

Focus on atrial function: benefits of three-dimensional speckle-tracking echocardiography

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