Arthriniumsteroids A–D, four new steroids from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212

Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral Genus Sinularia since 2013

“…In particular, sulfur or nitrogen-containing metabolites are a special, relatively rare, and important class of natural products from soft coral (such as compounds 59 and 249), which suggested that the symbiotic microorganisms are the real producers. According to the reported literature, soft coral also harbors a microbial community featuring sponges and ascidians [94], including fungus, bacteria, and actinobacteria [95][96][97][98], which also corresponds to the antimicrobial activity of coral-derived natural products. The extensive structure-activity relationship studies on the metabolites from Sinularia species are expected, which provide a direction for the discovery of lead compounds.…”

“…A solvent extract of S. polydactyla resulted in the isolation of two new casbane diterpenes: sinularcasbane M (94) and sinularcasbane N (95). Compounds were elucidated based on spectroscopic analyses; the absolute configuration was confirmed by X-ray analysis [57].…”

Marine natural products

“…Genome sequencing resulted in the identification of the genomic locus of a key enzyme involved in the biosynthesis of these metabolites. 238 Phenols 680 and 681 were isolated from Roussoella siamensis , 239 feeding of anthranilic acid and phthalimide to a Scedosporium apiospermum culture resulted in production of diphenylamine derivative 682 , 240 cyclic decapeptides 683–686 were obtained from Sesquicillium microsporum , 241 and soft coral-derived Symplicium strains yielded steroid derivatives 687–690 , 242 and nortriterpenoids 691–701 . 243…”

Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities

“…Four new compounds, arthriniumsteroids A−D ( 385 – 388 ), together with a known compound named eoaspergillic acid ( 389 ), were obtained from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212. All compounds displayed weak inhibitory activities against LPS-induced NO production in RAW 264.7 cells with inhibitory rates ranging from 21.4%−44.6% [ 170 ]. Four new steroid derivatives, penicildiones A−D ( 390 – 393 ), together with a described compound, stachybotrylactone B ( 394 ), were given by soft coral-derived fungus Penicillium sp.…”