Arthritis and aging

Abyad, Abdulrazak; Boyer, John T.

doi:10.1097/00002281-199204000-00004

Cited by 38 publications

(23 citation statements)

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“…Among the various subtypes of arthritis, rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common in the general population (Abyad and Boyer 1992). RA is an autoimmune disease in which an as yet unknown trigger results in a chronic inflammatory process affecting the synovial membrane of the joints (Gabriel 2001), while OA is often thought to result from natural aging processes on the joint surfaces (Sharma et al 2006).…”

mentioning

confidence: 99%

Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women

Lee

Steffes

Jacobs

2007

Environ Health Perspect

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BackgroundPersistent organic pollutants (POPs) can influence the immune system, possibly increasing the risk of rheumatoid arthritis (RA). In addition, as metabolic change due to obesity has been proposed as one mechanism of osteoarthritis (OA), POPs stored in adipose tissue may be also associated with OA.ObjectiveOur goal in this study was to examine associations of background exposure to POPs with arthritis among the general population.DesignWe investigated cross-sectional associations of serum POPs concentrations with the prevalence of self-reported arthritis in 1,721 adults ≥ 20 years of age in the National Health and Nutrition Examination Survey 1999–2002.ResultsAmong several POPs, dioxin-like polychlorinated biphenyls (PCBs) or nondioxin-like PCBs were positively associated with arthritis in women. After adjusting for possible confounders, odds ratios (ORs) were 1.0, 2.1, 3.5, and 2.9 across quartiles of dioxin-like PCBs (p for trend = 0.02). Corresponding figures for nondioxin-like PCBs were 1.0, 1.6, 2.6, and 2.5 (p for trend = 0.02). Organochlorine (OC) pesticides were also weakly associated with arthritis in women. For subtypes of arthritis, respectively, RA was more strongly associated with PCBs than was OA. The adjusted ORs for RA were 1.0, 7.6, 6.1, and 8.5 for dioxin-like PCBs (p for trend = 0.05), 1.0, 2.2, 4.4, and 5.4 for nondioxin-like PCBs (p for trend < 0.01), and 1.0, 2.8, 2.7, and 3.5 for OC pesticides (p for trend = 0.15). POPs in men did not show any clear relation with arthritis.ConclusionsThe possibility that background exposure to PCBs may be involved in pathogenesis of arthritis, especially RA, in women should be investigated in prospective studies.

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confidence: 99%

Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women

Lee

Steffes

Jacobs

2007

Environ Health Perspect

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“…Among these changes are decreased response to growth factors such as transforming growth factor ␤ (TGF␤) and insulin-like growth factor 1, increased apoptosis, and decreased extracellular matrix production (7,8). Compounding the latter events are the phenotypic changes in chondrocytes that occur during OA, a disease that has a high correlation with age (9,10). These alterations, collectively, place a limit on the usefulness of autologous chondrocytes isolated from aged OA joints in the therapeutic strategies mentioned above.…”

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confidence: 99%

Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase

Piera-Velázquez¹,

Jimenez²,

Stokes³

2002

Arthritis & Rheumatism

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Objective. To extend the life span of human osteoarthritic (OA) articular chondrocytes by introduction of the catalytic component of human telomerase while preserving the chondrocyte-specific phenotype.Methods. Human articular chondrocytes were isolated from the femoral head and tibial plateau of patients undergoing knee joint replacement for OA. The chondrocytes were cultured as monolayers and infected with a retroviral telomerase expression construct followed by selection with G418 for 10-14 days. Telomericrepeat amplification protocol assays and telomere terminal restriction fragment length assays were performed on pools of transduced cells in order to measure telomerase activity and telomere length. Growth kinetics and population doubling capacity were assessed by passaging the cells in monolayer culture. Redifferentiation of the monolayer chondrocyte cultures was induced by transfer to suspension culture on poly-(2-hydroxyethyl-methacrylate) (polyHEMA)-coated dishes. Induction of the chondrocyte-specific phenotype was monitored by analysis of gene expression utilizing reverse transcription-polymerase chain reaction.Results. OA chondrocytes isolated from 3 different donors (ages 41, 69, and 75 years) were transduced with a retroviral construct expressing telomerase. After selection, pooled populations of cells from all donors and a clonal cell line from 1 donor expressed telomerase activity and exhibited lengthening of telomeres. Chondrocytes expressing telomerase showed an increase of 5-9 population doublings over 234 days of culture in monolayer. The telomerase-transduced cells recovered a chondrocyte-specific gene expression pattern following culture on polyHEMA-coated dishes.Conclusion. The exogenous expression of telomerase may represent a way to expand human OA chondrocytes while allowing maintenance of the chondrocytespecific phenotype. These cells have the potential to be used for restoration of the articular cartilage defects occurring in this disease.

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“…Among age-related changes in cartilage are a reduction in tissue cellularity and abnormal matrix calcification or crystal deposition (2,3). Careful studies have shown evidence for a decrease in cartilage cellular density in femoral condyles from autopsy specimens of older donors by approximately 50%.…”

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Chondrocyte-derived apoptotic bodies and calcification of articular cartilage

Hashimoto

Ochs

Rosen

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

257

206

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Chondrocytes exposed to nitric oxide (NO) or antibody to Fas undergo cell death by apoptosis. This study examines structural and functional properties of chondrocyte-derived apoptotic bodies. In NO treated cartilage, the dense pericellular matrix that normally surrounds the cells is degraded and apoptotic bodies accumulate within and in the vicinity of the chondrocyte lacunae. Functional analysis shows that apoptotic bodies isolated from NO-treated chondrocytes or cartilage produce pyrophosphate. The levels of pyrophosphate produced by apoptotic bodies are increased by pretreatment of the chondrocytes with transforming growth factor ␤ and decreased by interleukin 1. Apoptotic bodies contain alkaline phosphatase and NTP pyrophosphohydrolase activities and can precipitate calcium. These results suggest that chondrocyte-derived apoptotic bodies express functional properties that may contribute to the pathologic cartilage calcification observed in aging and osteoarthritis.

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Arthritis and aging

Cited by 38 publications

References 0 publications

Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women

Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women

Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase

Chondrocyte-derived apoptotic bodies and calcification of articular cartilage

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