Arthritis associated with Kawasaki disease: MRI findings and serum matrix metalloproteinase‐3 profiles

Izumi, Gaku; Narugami, Masashi; Saita, Yoshinori; Matsuzawa, Tohru; Sugawara, Osamu; Kawamura, Nobuaki; Kobayashi, Ichiro

doi:10.1111/j.1442-200x.2011.03393.x

Cited by 15 publications

(11 citation statements)

References 14 publications

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“…As in KD patients with late‐onset arthritis, neither erosions of the bone nor bone marrow edema, characteristic of JIA, were detected on MRI in the present case. Severe joint lesion destruction may not be caused in KD‐related arthritis because of its self‐limiting nature.…”

contrasting

confidence: 61%

“…The articular symptoms improve with treatment for KD, and a non‐steroidal anti‐inflammatory drug (NSAID) is not necessary in most patients with early‐onset arthritis . In the present case the symptoms improved without NSAID, unlike patients with late‐onset arthritis . The mechanism underlying KD‐related arthritis may vary depending on the time of onset.…”

mentioning

confidence: 72%

“…3 In the present case the symptoms improved without NSAID, unlike patients with late-onset arthritis. 4 The mechanism underlying KD-related arthritis may vary depending on the time of onset.…”

mentioning

confidence: 99%

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Kawasaki disease‐related arthritis with synovial involvement

Ito

Hoshina

Taku

et al. 2018

Pediatrics International

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contrasting

confidence: 61%

mentioning

confidence: 72%

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Kawasaki disease‐related arthritis with synovial involvement

Ito

Hoshina

Taku

et al. 2018

Pediatrics International

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“…Early onset type in KD occurs during the first 7 -10 days of illness, continues for 20 days, and tends to involve multiple joints such as small interphalangeal joints as well as large weight-bearing joints (1,2). On the other hand, late-onset type develops usually on the 10th day of illness or later, generally affects especially the knees and ankles, and lasts in many different days from 15 days to 6 -8 weeks (1)(2)(3)(4). In general, arthritis in KD reacts dramatically when the treatment with intravenous immunoglobulin (IVIG) is started and is a non-erosive synovitis that has excellent outcomes with no sequelae (1,3,4).…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Late Onset Arthritis in Kawasaki Disease

et al. 2019

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Objectives: The aim of this study was to report the prevalence, clinical course, and sequela of arthritis in Kawasaki disease (KD), and to establish its relationship to coronary outcomes. Methods: We retrospectively reviewed the records of 524 patients between March 2006 and February 2016. Results: The overall prevalence of arthritis was 17.6 % (n = 92/524) and among them, 21 cases (22.8%) had late-onset arthritis and they were older (32.7 ± 12.1 vs. 62.5 ± 23.8 months), had longer fever duration (5.8 ± 1.94 vs. 7.11 ± 2.51 days), more frequent swelling or redness of extremities (35.2 vs. 71.5%), higher neutrophil counts (58.69 ± 13.84 vs. 72.16 ± 16.43%), and higher prohormone brain-type natriuretic peptide levels (ProBNP, 1343.80 ± 1080.44 vs. 3754.42 ± 4272.71 pg/mL) than patients with early onset arthritis. Coronary artery changes were not different and no patients complained of chronic arthritic changes, regardless of arthritis type. Conclusions: Although late-onset arthritis was found in KD patients who were older with longer fever duration, more frequent swelling or redness of extremities, higher neutrophil counts, and higher ProBNP levels than early-onset arthritis patients, there was no statistical significance between arthritis onset type and coronary artery changes, and outcomes were excellent with no chronic arthritis change.

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“…MMP‐3 is produced by chondrocytes and by cells within the synovium and hydrolyzes the macromolecules such as aggrecan, fibronectin and type II collagen . Serum MMP‐3 has been reported to evaluate disease activity not only in rheumatoid arthritis, but also in other rheumatic diseases . Nevertheless, previous studies have not been able to explain how knee CC affects the serum concentration of MMP‐3.…”

Section: Introductionmentioning

confidence: 99%