Artifacts in polarization-sensitive optical coherence tomography caused by polarization mode dispersion

Villiger, Martin; Zhang, Ellen Ziyi; Nadkarni, Seemantini K.; Oh, Wang‐Yuhl; Bouma, Brett E.; Vakoc, Benjamin J.

doi:10.1364/ol.38.000923

Cited by 48 publications

(44 citation statements)

References 11 publications

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“…Recent studies have suggested that polarization mode dispersion (PMD) increases polarimetric noise in PS-OCT [35,36]. Some methods have been developed to overcome this issue using various approaches [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

Yamanari

Tsuda

Kokubun

et al. 2015

Biomed. Opt. Express

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Abstract:We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies of the anterior eye segment imaging. The system can measure Jones matrices of the sample with depth-multiplexing of two orthogonal incident polarizations and polarization-sensitive detection. An optical clock is generated using a quadrature modulator and a logical circuit to double the clock frequency. Systematic artifacts in measured Jones matrices are theoretically analyzed and numerically compensated using signals at the surface of the sample. Local retardation images of filtering blebs after trabeculectomy show improved visualization of subconjunctival tissue, sclera, and scar tissue of the bleb wall in the anterior eye segment. 37. B. Braaf, K. A. Vermeer, M. de Groot, K. V. Vienola, and J. F. de Boer, "Fiber-based polarization-sensitive OCT of the human retina with correction of system polarization distortions," Biomed.

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Section: Introductionmentioning

confidence: 99%

Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

Yamanari

Tsuda

Kokubun

et al. 2015

Biomed. Opt. Express

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“…Following the finding that polarization mode dispersion in the OCT interferometer and catheters inhibits accurate and reproducible polarimetry [107], methods were identified to mitigate this effect and enable intravascular birefringence [108,109] and depolarization [110] measurements. This work has recently been translated into clinical studies with intriguing results demonstrating the very promising utility of polarimetry for vascular and plaque characterization [37,38].…”

Section: Discussionmentioning

confidence: 99%

Intravascular optical coherence tomography [Invited]

Bouma

Villiger

Otsuka

et al. 2017

Biomed. Opt. Express

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Shortly after the first demonstration of optical coherence tomography for imaging the microstructure of the human eye, work began on developing systems and catheters suitable for intravascular imaging in order to diagnose and investigate atherosclerosis and potentially to monitor therapy. This review covers the driving considerations of the clinical application and its constraints, the major engineering milestones that enabled the current, highperformance commercial imaging systems, the key studies that laid the groundwork for image interpretation, and the clinical research that traces intravascular optical coherence tomography (OCT) from early human pilot studies to current clinical trials. Fujimoto, "Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology," Circulation 93(6), 1206-1213 (1996). 4. D. Mozaffarian, E. Benjamin, A. Go, D. K. Arnett, M. J. Blaha, M. Cushman, S. R. Das, M. Sarah de Ferranti, J.-P. Després, and H. J. Fullerton, AHA Statistical Update: Heart Disease and Stroke Statistics (AHA, 2015). 5. E. Falk, P. K. Shah, and V. Fuster, "Coronary plaque disruption," Circulation 92(3), 657-671 (1995). 6. R. T. Lee and P. Libby, "The unstable atheroma," Arterioscler. Thromb. Vasc. Biol. 17(10), 1859-1867 (1997). 7. G. K. Sukhova, U. Schönbeck, E. Rabkin, F. J. Schoen, A. R. Poole, R. C. Billinghurst, and P. Libby, "Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques," Circulation 99(19), 2503-2509 (1999). 8. R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 20(5), 1262-1275 (2000). 9. J. A. Condado, R. Waksman, O. Gurdiel, R. Espinosa, J. Gonzalez, B. Burger, G. Villoria, H. Acquatella, I. R.Crocker, K. B. Seung, and S. F. Liprie, "Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans," Circulation 96(3), 727-732 (1997). 10. P. S. Teirstein, V. Massullo, S. Jani, J. J. Popma, G. S. Mintz, R. J. Russo, R. A. Schatz, E. M. Guarneri, S. Steuterman, N. B. Morris, M. B. Leon, and P. Tripuraneni, "Catheter-based radiotherapy to inhibit restenosis after coronary stenting," N. Engl. J. Med. 336(24), 1697-1703 (1997). 11. P. G. Yock and P. J. Fitzgerald, "Intravascular ultrasound: state of the art and future directions," Am. J. Cardiol. 81(7 7A), 27E-32E (1998). 12. P. G. Yock, P. J. Fitzgerald, D. T. Linker, and B. A. Angelsen, "Intravascular ultrasound guidance for catheterbased coronary interventions," J. Am. Coll. Cardiol. 17(6), 39-45 (1991). 13. F. M. Baer, P. Theissen, J. Crnac, M. Schmidt, M. Jochims, and H. Schicha, "MRI assessment of coronary artery disease," Rays 24(1), 46-59 (1999). 14. G. G. Zimmermann-Paul, H. H. Quick, P. Vogt, G. K. von Schulthess, D. Kling, and J. F. Debatin, "Highresolution intravascular magnetic res...

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“…In fiber-based PS-OCT systems, PMD 40 in fiber and optical components, such as the circulator, are believed to contribute to the polarimetric noise in the birefringence measurement, 41,42 and approaches have been proposed to compensate for the PMD introduced by SMF and other optical components. 43 Structural properties of tissue also contribute to polarimetric noise.…”

Section: Discussionmentioning

confidence: 99%

Degradation in the degree of polarization in human retinal nerve fiber layer

et al. 2014

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Abstract. Using a fiber-based swept-source (SS) polarization-sensitive optical coherence tomography (PS-OCT) system, we investigate the degree of polarization (DOP) of light backscattered from the retinal nerve fiber layer (RNFL) in normal human subjects. Algorithms for processing data were developed to analyze the deviation in phase retardation and intensity of backscattered light in directions parallel and perpendicular to the nerve fiber axis (fast and slow axes of RNFL). Considering superior, inferior, and nasal quadrants, we observe the strongest degradation in the DOP with increasing RNFL depth in the temporal quadrant. Retinal ganglion cell axons in normal human subjects are known to have the smallest diameter in the temporal quadrant, and the greater degradation observed in the DOP suggests that higher polarimetric noise may be associated with neural structure in the temporal RNFL. The association between depth degradation in the DOP and RNFL structural properties may broaden the utility of PS-OCT as a functional imaging technique.

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Artifacts in polarization-sensitive optical coherence tomography caused by polarization mode dispersion

Cited by 48 publications

References 11 publications

Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

Intravascular optical coherence tomography [Invited]

Degradation in the degree of polarization in human retinal nerve fiber layer

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