This paper introduces and implements an efficient training method for deep learning–based anomaly area detection in the depth image of a tire. A depth image of 16 bit integer size is used in various fields, such as manufacturing, industry, and medicine. In addition, the advent of the 4th Industrial Revolution and the development of deep learning require deep learning–based problem solving in various fields. Accordingly, various research efforts use deep learning technology to detect errors, such as product defects and diseases, in depth images. However, a depth image expressed in grayscale has limited information, compared with a three-channel image with potential colors, shapes, and brightness. In addition, in the case of tires, despite the same defect, they often have different sizes and shapes, making it difficult to train deep learning. Therefore, in this paper, the four-step process of (1) image input, (2) highlight image generation, (3) image stacking, and (4) image training is applied to a deep learning segmentation model that can detect atypical defect data. Defect detection aims to detect vent spews that occur during tire manufacturing. We compare the training results of applying the process proposed in this paper and the general training result for experiment and evaluation. For evaluation, we use intersection of union (IoU), which compares the pixel area where the actual error is located in the depth image and the pixel area of the error inferred by the deep learning network. The results of the experiment confirmed that the proposed methodology improved the mean IoU by more than 7% and the IoU for the vent spew error by more than 10%, compared to the general method. In addition, the time it takes for the mean IoU to remain stable at 60% is reduced by 80%. The experiments and results prove that the methodology proposed in this paper can train efficiently without losing the information of the original depth data.