Artificially intelligent nanoarrays for disease detection via volatolomics

Abstract

Delayed diagnosis of many diseases is caused by technology limitations of currently available methods.Therefore, there is a need for novel technology that would allow efficient early detection, population stratification for personalized therapy, and for rapid assessment of treatment efficacy. Such an emerging approach is based on artificially intelligent sensing arrays of solid-state or flexible sensors that detect the so-called "volatolomics", viz. profiles of volatile organic compounds (VOCs) which are by-products of metabolic processes and emit from various body fluids.

Artificially Intelligent Nanoarray Detects Various Cancers by Liquid Biopsy of Volatile Markers

“…In the second stage, the headspace of the blood samples collected from the animal models were analyzed by sensor array composed of chemiresistors based on spherical gold nanoparticles (GNPs) capped with different organic layer, and 2D random networks of single‐walled carbon nanotubes (RN‐SWCNTs) capped with different polymeric composites in conjugation with ML methods (see Experimental Section and Supporting Information for detailed working mechanism). [ 56–58,60,62–68 ] The rationale behind using two different sensing surfaces is that different transducers (being based on different physical quantities) can provide orthogonal information. [ 58 ] The GNP sensors are sensitive to molecules adsorbed between adjacent nanoparticles and therefore they excel in the detection of nonpolar VOCs—an important portion of the VOCs clinical samples.…”

“…the adaptable approach of nanoarray. [ 62–65,69,87–90 ] Arguably, the reported artificially intelligent nanoarray is better fit for fast diagnostic approaches in which assessment of a VOC collection is qualitative and semi‐quantitative. Selectivity is attained through pattern recognition of the collection.…”

Autonomous Micro-Air-Vehicle Control Based on Visual Sensing for Odor Source Localization

“…Therefore, ultra-sensitive odor sensors will be required. Gas sensors with parts-per-quadrillion (ppq) sensitivity have been reported [3].…”

“…Gas sensors with parts-perquadrillion (ppq) sensitivity have been reported [2]. As gas sensors are improved, new safety systems and disease-detection systems are being designed using gas sensors [2,3]. This paper is an extension of work originally presented in 2016 23rd International Conference on Mechatronics and Machine Vision in Practice (M2VIP 2016) [4].…”