Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population

Chelouti, Hiba; Khelil, Malika

doi:10.1080/03014460.2017.1311373

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Berdasarkan frekuensi kejadian hepatotoksik, pemilik NAT2 asetilator lambat di Indonesia berkisar 48,9-73,9% [11], [12], [34]. Jumlah kejadian pada rentang tersebut juga terjadi pada populasi di Aljazair (53%) [35], Argentina (53,6%) [36], Iran (63,4%) [37], Maroko (70%) [38].…”

Section: Pembahasanunclassified

Resiko Hepatotoksik Populasi Indonesia Akibat Polimorfisme Enzim NAT2 dan CYP2E1 dalam Metabolisme Isoniazid

Santoso

Chabibah

Pribadi

2021

UJAS

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Artikel ini menyajikan data profil resiko kejadian hepatotoksik akibat polimorfisme NAT2 dan CYP2E1 dalam metabolisme isoniazid pada populasi Indonesia di antara berbagai populasi sejumlah negara. Penelitian berlangsung melalui telaah pustaka yang diperoleh dari google schoolar. Pencarian pustaka menggunakan tiga varian kata kunci; (1) “pharmacogenomic dan tuberculosis dan INH dan NAT2 dan CYP2E1 dan polymorphism”, (2) “isoniazid dan hepatotoxicity dan polymorphism dan N-acetyltransferase”, (3) “isoniazid dan hepatotoxicity dan polymorphism dan CYP2E1”. Analisis resiko hepatotoksik berdasarkan nilai odd ratio (confidence interval) menggunakan software Stata MP edisi 14. Telaah resiko hepatotoksik berdasarkan ragam kecepatan asetilasi NAT2 melibatkan 2.140 populasi dari 8 negara, sedangkan telaah resiko berdasarkan ragam alel CYP2E1 melibatkan 1.530 populasi dari 5 negara. Hasil telaah pustaka menunjukkan bahwa resiko hepatotoksik akibat induksi isoniazid pada populasi Indonesia yang memiliki enzim NAT2 asetilator lambat dan orang dengan CYP2E1*c1/c2, tiga kali lebih tinggi dari populasi lain di berbagai negara. Potensi resiko akan meningkat pada orang yang memiliki kombinasi NAT2 asetilator lambat dan CYP2E1*c1/c2.

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Section: Pembahasanunclassified

Resiko Hepatotoksik Populasi Indonesia Akibat Polimorfisme Enzim NAT2 dan CYP2E1 dalam Metabolisme Isoniazid

Santoso

Chabibah

Pribadi

2021

UJAS

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N‐acetyltransferase 2 polymorphism and acetylation profiles in Buginese ethnics of Indonesia

Yuliwulandari

Susilowati

Razari

et al. 2019

Annals of Human Genetics

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Background N‐acetyltransferase 2 (NAT2) is a key enzyme involved in the phase II metabolism of aromatic amines and heterocyclic aromatic amines present in a wide range of xenobiotics. The aim of this study was to investigate the NAT2 polymorphism in the Buginese ethnic group of Indonesia to determine the frequency of NAT2 alleles in this population. Results We found six haplotypes consisting of six single‐nucleotide polymorphisms and 12 NAT2 genotype variations. NAT2*6A haplotype (42%) showed the highest frequency, followed by NAT2*4 (33%), NAT2*7B (15%), NAT2*5B (5%), NAT2*12A (3%), and NAT2*13 (2%). In terms of phenotypes, the Buginese population comprised 18% rapid acetylators, 40% intermediate acetylators, and 42% slow acetylators. Conclusion We confirmed the high‐frequency slow acetylator phenotype in the Buginese population. The NAT2*6A/*6A genotype was the most frequent slow acetylator genotype, followed by NAT2*6A/*7B. The pattern of NAT2 alleles of Buginese is similar to Southeast Asian populations but not Northeast Asian populations. However, the slow acetylator frequencies in the Buginese population were higher than those in Northeast Asian populations and lower than those in Caucasians and some American populations.

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Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population

Abstract: Our results suggest that the high frequency of slow acetylator phenotype requires investigation into its possible association with ATDH.

Cited by 2 publications

References 30 publications

Resiko Hepatotoksik Populasi Indonesia Akibat Polimorfisme Enzim NAT2 dan CYP2E1 dalam Metabolisme Isoniazid

Resiko Hepatotoksik Populasi Indonesia Akibat Polimorfisme Enzim NAT2 dan CYP2E1 dalam Metabolisme Isoniazid

N‐acetyltransferase 2 polymorphism and acetylation profiles in Buginese ethnics of Indonesia

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