Asbestos Fibres in Beverages and Drinking Water

Cunningham, H. M.; Pontefract, R. D.

doi:10.1038/232332a0

Cited by 115 publications

(34 citation statements)

References 9 publications

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“…Recent autopsy studies have documented the presence of asbestos, not only in children but also in stillborn infants, with the latter suggesting transplacental transfer of asbestos fibers (Haque et al, 1990(Haque et al, , 1996. The uptake and circulation of asbestos fibers after ingestion and their distribution to various organs have been demonstrated in several adult human as well as animal studies (Carter & Taylor, 1980;Cook & Olson, 1979;Cunningham & Pontefract, 1973;Hallenbeck & Patel-Mandlik, 1979).…”

mentioning

confidence: 95%

Chrysotile Asbestos Fibers Detected in the Newborn Pups Following Gavage Feeding of Pregnant Mice

Haque

Ali

Vrazel

et al. 2000

Journal of Toxicology and Environmental Health, Part A

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Female pregnant mice were fed chrysotile asbestos suspension by gavage to determine whether there is transfer of fibers to the fetuses. Groups of mice were given 2 doses of either 50 microg chrysotile suspension in 0.2 ml sterile normal saline (treated), or 0.2 ml saline (control), and were allowed to mate 2 d later. After pregnancy was confirmed, the treated and control groups received 2 additional doses of chrysotile asbestos or saline on gestational d 7 and 12. Both groups were allowed to deliver naturally, and the pups were sacrificed at 8, 1, 19, or 20 d after birth. The lungs and liver of two pups from each mother were processed for fiber counts using electron microscopy and energy-dispersive x-ray analysis (EDXA). All pups of the treated group had chrysotile fibers, while none were present in pups from controls. The mean fiber count of the lungs of treated group of pups was 780 fibers/g, and the mean fiber count of the liver was 214 fibers/g. Mean length of the fibers in the lung and liver was 18.48 microm and 18.30 microm, respectively. The fibers were thin, measuring 0.42 microm and 0.33 microm in the lung and liver, respectively. There was no significant difference in the weight gain between the treated and control group of pups. The postnatal fetal mortality of the 2 groups, 8.2% for the treated and 4.5% for the control group, were not statistically significant. To our knowledge, this is the first animal study to demonstrate that oral ingestion of chrysotile asbestos during pregnancy results in transfer of asbestos fibers to the fetuses.

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mentioning

confidence: 95%

Chrysotile Asbestos Fibers Detected in the Newborn Pups Following Gavage Feeding of Pregnant Mice

Haque

Ali

Vrazel

et al. 2000

Journal of Toxicology and Environmental Health, Part A

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“…The authors point out that beer tends to be more strongly associated with colorectal cancer suggesting that it is not alcohol itself, but some other component of beer that maybe responsible for the increased risk. Though the findings are speculative, carcinogens, such as nitrosamine and asbestos fibers, have been found in a variety of beer and other types of alcoholic beverages (Walker et al, 1979;Biles and Emerson, 1968;Cunningham and Pontefract, 1971).…”

Section: Alcohol Consumption and Its Link To Cancermentioning

confidence: 96%

Alcohol and cancer: a review for psycho-oncologists

Lundberg¹,

Passik²

1997

Psycho-Oncology

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“…The grid squares were counted as described previously (Cunningham and Pontefract, 1971). Most of the fibers could be identified by electron diffraction, but in cases where too much leaching had taken place identification was often possible with the assistance of a semiconductor X-ray detector on a Siemens 101 transmission electron microscope.…”

Section: Methodsmentioning

confidence: 99%

Quantitative relationship of fecal asbestos to asbestos exposure

Cunningham¹,

Pontefract²,

O'Brien³

1976

Journal of Toxicology and Environmental Health

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A method is descirbed for isolating chrysotile fibers from feces and counting them with an electron microscope. The detection limit was 150,000 fibers per gram feces; average recovery was 85.5%. When the method was used to check the asbestos in feces of people subjected to industrial exposure vs. controls, the means were significantly different (p less than 0.02). Duplicate fecal samples were found to check within an average of +/- 31.1% of their means.

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Asbestos Fibres in Beverages and Drinking Water

Cited by 115 publications

References 9 publications

Chrysotile Asbestos Fibers Detected in the Newborn Pups Following Gavage Feeding of Pregnant Mice

Chrysotile Asbestos Fibers Detected in the Newborn Pups Following Gavage Feeding of Pregnant Mice

Alcohol and cancer: a review for psycho-oncologists

Quantitative relationship of fecal asbestos to asbestos exposure

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