Asbestos in commercial cosmetic talcum powder as a cause of mesothelioma in women

Lee, Richard; Orden, Drew Van

doi:10.1080/10773525.2015.1122370

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…The type and number of fibers that could potentially be inhaled during normal use of talcum powder were found to be superimposable on those detected in the lung tissue of a woman who died of mesothelioma. The debate sparked by this paper led to several works focusing on this topic until last year with controversial results [ 35 , 37 , 184 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 ]. For example, it should be emphasized that no excesses of pleural mesothelioma nor talc pneumoconiosis were found in studies of miners in talc mines [ 177 , 225 , 226 , 227 , 228 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

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Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is fundamental to gain greater awareness of this neoplasm and try to answer unsolved questions. Herein, we described four cases of histological diagnoses of ovarian mesothelioma extrapolated by the regional mesothelioma register of Apulia (southern Italy). In all cases, a detailed medical history was collected according to national mesothelioma register guidelines. A broad panel of antibodies was used for immunohistochemistry to confirm the diagnoses. Moreover, ovarian tissue samples were also examined by transmission and scanning electron microscopy, detecting asbestos fibers and talc crystals in two cases. Because of the few cases described, we reviewed the English literature in the Medline database, focusing on articles about ovarian mesothelioma “misclassification”, “misdiagnosis”, “diagnostic challenge” or “diagnostic pitfall” and on unsolved questions about its histogenesis and possible risk factors.

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Section: Discussionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

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“…Recent publications have continued to assert that exposure to talcum powder containing tremolite and anthophyllite asbestos is likely a contributing or causative factor for developing mesothelioma (Gordon et al ., ; Gordon ). However, others have noted analytical challenges associated with characterizing the composition of fibers found in such products and numerous factors limiting the interpretation of epidemiology studies (Crane, ; Honda et al ., ; Lee and Van Orden, ). In addition, the potential for talc usage contributing to anthophyllite fibers identified in lung fiber burden analyses must also be carefully examined.…”

Section: Discussionmentioning

confidence: 99%

Anthophyllite asbestos: state of the science review

Gaffney

Grespin²,

Garnick

et al. 2016

J of Applied Toxicology

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Anthophyllite is an amphibole form of asbestos historically used in only a limited number of products. No published resource currently exists that offers a complete overview of anthophyllite toxicity or of its effects on exposed human populations. We performed a review focusing on how anthophyllite toxicity was understood over time by conducting a comprehensive search of publicly available documents that discussed the use, mining, properties, toxicity, exposure and potential health effects of anthophyllite. Over 200 documents were identified; 114 contained relevant and useful information which we present chronologically in this assessment. Our analysis confirms that anthophyllite toxicity has not been well studied compared to other asbestos types. We found that toxicology studies in animals from the 1970s onward have indicated that, at sufficient doses, anthophyllite can cause asbestosis, lung cancer and mesothelioma. Studies of Finnish anthophyllite miners, conducted in the 1970s, found an increased incidence of asbestosis and lung cancer, but not mesothelioma. Not until the mid-1990s was an epidemiological link with mesothelioma in humans observed. Its presence in talc has been of recent significance in relation to potential asbestos exposure through the use of talc-containing products. Characterizing the health risks of anthophyllite is difficult, and distinguishing between its asbestiform and non-asbestiform mineral form is essential from both a toxicological and regulatory perspective. Anthophyllite toxicity has generally been assumed to be similar to other amphiboles from a regulatory standpoint, but some notable exceptions exist. In order to reach a more clear understanding of anthophyllite toxicity, significant additional study is needed. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The accuracy of Dr Gordon's identification of asbestiform fibers in talcum powder has been questioned. 8 Further, the article by Gordon et al 5 is a case report. Case reports do not estimate disease frequency or risk because of the absence of a valid denominator and do not provide any methodologic basis for determining general causation.…”

mentioning

confidence: 98%

Malignant Mesothelioma and Its Nonasbestos Causes: Talcum Powder Does Not Create Occult Asbestos Exposure

Geyer¹

2019

Archives of Pathology &Amp; Laboratory Medicine

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Asbestos in commercial cosmetic talcum powder as a cause of mesothelioma in women

Cited by 10 publications

References 12 publications

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Anthophyllite asbestos: state of the science review

Malignant Mesothelioma and Its Nonasbestos Causes: Talcum Powder Does Not Create Occult Asbestos Exposure

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