Ascaridole-rich essential oil from marsh rosemary (Ledum palustre) growing in Poland exerts insecticidal activity on mosquitoes, moths and flies without serious effects on non-target organisms and human cells

Benelli, Giovanni; Pavela, Roman; Cianfaglione, Kevin; Sender, Joanna; Urban, Danuta; Maślanko, Weronika; Canale, Angelo; Barboni, Luciano; Petrelli, Riccardo; Zeppa, Laura; Aguzzi, Cristina; Maggi, Filippo

doi:10.1016/j.fct.2020.111184

Cited by 34 publications

(23 citation statements)

References 81 publications

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“…In particular, EOs show various biological properties including attractive, antifeedant, deterrent, and toxic effects on numerous phytophagous insects [ 25 , 39 ]. Toxic and repellent activity of EOs were tested on several pests of agricultural and medical interest [ 40 , 41 , 42 , 43 , 44 ], including tephritid flies [ 5 , 45 , 46 , 47 , 48 , 49 ]. In the present review, we summarized the current status of the experiments carried out on Tephritidae, in which the toxic and attractive activities of EOs and their main constituents were evaluated.…”

Section: Biological Activity Of Essential Oils and Their Constituentsmentioning

confidence: 99%

Toxics or Lures? Biological and Behavioral Effects of Plant Essential Oils on Tephritidae Fruit Flies

et al. 2021

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The family Tephritidae (Diptera) includes species that are highly invasive and harmful to crops. Due to globalization, international trade, and human displacement, their spread is continuously increasing. Unfortunately, the control of tephritid flies is still closely linked to the use of synthetic insecticides, which are responsible for detrimental effects on the environment and human health. Recently, research is looking for alternative and more eco-friendly tools to be adopted in Integrated Pest Management (IPM) programs. In this regard, essential oils (EOs) and their main compounds represent a promising alternative to chemical insecticides. EOs are made up of phytoconstituents formed from the secondary metabolism of many plants and can act as attractants or toxics, depending on the dose. Because of this unique characteristic, EOs and their main constituents are promising tools that can be used both in Sterile Insect Technique (SIT) programs and in the “lure and kill” technique, exploiting the attractiveness of the product in the former case and its toxicity in the latter. In this article, current knowledge on the biological and behavioral effects of EOs and their main constituents on tephritid fruit flies is reviewed, mainly focusing on species belonging to the Anastrepha, Bactrocera, Ceratitis, and Zeugodacus genera. The mechanisms of action of EOs, their real-world applications, and challenges related to their use in IPM are critically discussed.

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Section: Biological Activity Of Essential Oils and Their Constituentsmentioning

confidence: 99%

Toxics or Lures? Biological and Behavioral Effects of Plant Essential Oils on Tephritidae Fruit Flies

et al. 2021

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“…p-Cymene. p-Cymene is a monocyclic monoterpene in EOs of Saccocalyx satureioides, 58 Ledum palustre, 99 Peumus boldus, 71 Thymus vulgaris, 69 O. acutidens, 92 and Dysphania ambrosioides. 100 These EOs are toxic to various pest insects such as C. quinquefasciatus, Spodoptera littoralis, Musca domestica, T. ni, S. granaries, and T. confusum in laboratory screening bioassays.…”

Section: ■ Frequently Studied Monoterpenes With Pesticidal Activitiesmentioning

confidence: 99%

Pesticidal Activity and Mode of Action of Monoterpenes

Liu

Song

2022

J. Agric. Food Chem.

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Synthetic pesticides are often associated with issues such as pest resistance, persistent residue, nontarget toxicity, and environmental issues. Therefore, the research and development of novel, safe, and effective pesticides has become a focus in pesticide discovery. Monoterpenes are secondary plant metabolites that commonly have multiple action targets and have been used in aromatherapy, alternative medicine, and food industries. Some are highly potent and stereoselective. They can potentially be botanical pesticides and serve as lead candidates for the design and synthesis of new monoterpenoid pesticides for agricultural applications. This article reviews publications and patents found in SciFinder Scholar between 2000 and May 2021 on monoterpenes and mainly focuses on pesticidal activities of frequently studied monoterpenes and their modes of action. The presented information and our views are hopefully useful for the development of monoterpenes as biopesticides and monoterpenoid pesticides.

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“…Terpenoids have a wide variety and complex structure throughout the plant kingdom, including monoterpenes (myrcene), sesquiterpenes (artemisinin, gossypol), diterpenes (triptolide), triterpenes (oleanolic acid), tetraterpenes (β-carotene), and polyterpenoids (gutta-percha). Due to their different properties, physiological activities are varied, such as anti-malarial [37], anti-fertility [38], insecticidal activities [39], etc. Here, we will summarize the mechanisms through which terpenoids regulate mitochondrial function to stimulate anticancer effects that have been discovered in recent years (Figure 2).…”

Section: Terpenoidsmentioning

confidence: 99%

Natural Products Targeting the Mitochondria in Cancers

Yang

Zhang

et al. 2020

Molecules

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There are abundant sources of anticancer drugs in nature that have a broad prospect in anticancer drug discovery. Natural compounds, with biological activities extracted from plants and marine and microbial metabolites, have significant antitumor effects, but their mechanisms are various. In addition to providing energy to cells, mitochondria are involved in processes, such as cell differentiation, cell signaling, and cell apoptosis, and they have the ability to regulate cell growth and cell cycle. Summing up recent data on how natural products regulate mitochondria is valuable for the development of anticancer drugs. This review focuses on natural products that have shown antitumor effects via regulating mitochondria. The search was done in PubMed, Web of Science, and Google Scholar databases, over a 5-year period, between 2015 and 2020, with a keyword search that focused on natural products, natural compounds, phytomedicine, Chinese medicine, antitumor, and mitochondria. Many natural products have been studied to have antitumor effects on different cells and can be further processed into useful drugs to treat cancer. In the process of searching for valuable new drugs, natural products such as terpenoids, flavonoids, saponins, alkaloids, coumarins, and quinones cover the broad space.

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Ascaridole-rich essential oil from marsh rosemary (Ledum palustre) growing in Poland exerts insecticidal activity on mosquitoes, moths and flies without serious effects on non-target organisms and human cells

Cited by 34 publications

References 81 publications

Toxics or Lures? Biological and Behavioral Effects of Plant Essential Oils on Tephritidae Fruit Flies

Toxics or Lures? Biological and Behavioral Effects of Plant Essential Oils on Tephritidae Fruit Flies

Pesticidal Activity and Mode of Action of Monoterpenes

Natural Products Targeting the Mitochondria in Cancers

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