Ascidian-inspired aciduric hydrogels with high stretchability and adhesiveness promote gastric hemostasis and wound healing

Abstract

The hydrogel adhesives were formed via hydrogen bonds between the amide groups of PGA-DA and polyphenol groups of TA. The hydrogel adhesives exhibited strong adhesion, high stretchability, and rapid hemostatic performance.

Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol

“…The time required for adhesion to each substrate varied, although in general, it was around 5 minutes. In addition, these two copolymers, PGS- co -40PEG2 and PGS- co -60PEG3, were more flexible compared to other samples, which, since they are transparent, light weight and flexible, might have suitable medical applications such as wound dressing 68 or non-medical application for as adhesive sensors or for flexible devices ( Fig. 7C and ESI † ).…”

“…The time required for adhesion to each substrate varied, although in general, it was around 5 minutes. In addition, these two copolymers, PGS-co-40PEG2 and PGS-co-60PEG3, were more flexible compared to other samples, which, since they are transparent, light weight and flexible, might have suitable medical applications such as wound dressing 68 or non-medical application for as adhesive sensors or for flexible devices (Figure 7C and Supplementary Information). 69 Furthermore, it is possible for flexible materials to sense and adapt to changes in the microenvironment; such materials are capable of improving cellular mechanosensing by dynamically adjusting their topography and local mechanics.…”

Advances in Hydrogel Adhesives for Gastrointestinal Wound Closure and Repair

“…As discussed above, biomimetic catechol-based mussel-inspired hydrogels are extensively studied for wet adhesion. However, it is a challenge to fabricate catechol-based hydrogels for perforation sealing because strong adhesion and cohesion of the hydrogel require drastically different pH conditions, respectively [ 60 , 61 ]. Alternatively, tannic acid (TA) is a natural plant-based polyphenol containing a high density of pyrogallol and catechol groups that functions as a physical crosslinker as well as an adhesive moiety to facilitate both cohesion and adhesion in acidic conditions [ 61 , 62 ].…”

Hydrogels as promising carriers for the delivery of food bioactive ingredients

“…Hydrogels delivered to stomach often require strong adhesion and acid stability, which presents a challenge for the design of hydrogels. In clinical practice, for the treatment of gastric bleeding, a hydrogel based on Poly(γ-glutamic acid) and tannic acid ( 96 ) was designed. This hydrogel has strong adhesion under wet conditions, strong tensile properties that can withstand long-term mechanical forces, good biocompatibility and safety in clinical trials ( 96 ).…”

“…In clinical practice, for the treatment of gastric bleeding, a hydrogel based on Poly(γ-glutamic acid) and tannic acid ( 96 ) was designed. This hydrogel has strong adhesion under wet conditions, strong tensile properties that can withstand long-term mechanical forces, good biocompatibility and safety in clinical trials ( 96 ). Tough hydrogels with trigger properties can also withstand harsh acidic conditions in the stomach when ingested, and can change shape or expand to ensure long-term retention and mechanical integrity, resolving side effects by triggering dissolution ( 97 ).…”