Asiaticoside mimetics as wound healing agent

Shim, Pil-Jong; Park, Jae Ho; Chang, Min-Sun; Lim, Min-Jung; Kim, Do-Ha; Jung, Young Hoon; Jew, Sang‐sup; Park, Eun Hee; Kim, Hee-Doo

doi:10.1016/s0960-894x(96)00540-9

Cited by 20 publications

(13 citation statements)

References 9 publications

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“…Among the four major triterpenoid components of C. asiatica (i.e., asiatic acid, asiaticoside, madecassic acid and madecassoside), asiaticoside (see Fig. 1), a trisaccharide triterpene, is supposedly the most active compound associated with the healing of wounds, as evidenced by the observed increase in antioxidant levels at an initial stage of healing of excision-type cutaneous wounds in rats [19], the observed increase in the proliferation and the production of types I and III pro-collagen mRNA and protein levels of human dermal fibroblasts [20,21], and the stimulation of extracellular matrix accumulation in rat experimental wounds [22,23] in response to the presence of this substance.…”

Section: Introductionmentioning

confidence: 99%

Electrospun cellulose acetate fiber mats containing asiaticoside or Centella asiatica crude extract and the release characteristics of asiaticoside

Suwantong

Ruktanonchai

Supaphol

2008

Polymer

100

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Section: Introductionmentioning

confidence: 99%

Electrospun cellulose acetate fiber mats containing asiaticoside or Centella asiatica crude extract and the release characteristics of asiaticoside

Suwantong

Ruktanonchai

Supaphol

2008

Polymer

100

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“…Considering the importance of antioxidants in healing, we planned to study the effect of a known wound healer on the status of some enzymatic and non-enzymatic antioxidants in a healing wound. The compound tested is asiaticoside derived from plant Centella asiatica (Brahma-Mandukarni) which is known to possess healing activity in both normal as well as delayed type healing models as studied by our group (Shukla et al, 1998) and many other groups (Yoshinori et al, 1982;Rao et al, 1996;Shim et al, 1996). It has also been shown to possess fibroblast proliferating activity (Maquart et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Asiaticoside-induced elevation of antioxidant levels in healing wounds

1999

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Asiaticoside derived from the plant Centella asiatica is known to possess good wound healing activity. Enhanced healing activity has been attributed to increased collagen formation and angiogenesis. Since antioxidants have been reported to play a significant role in the wound healing process we studied the effect of asiaticoside on the levels of certain antioxidants in the wound so as to explore the possible involvement of such a mechanism in the asiaticoside induced wound healing. Asiaticoside application (0.2%, topical) twice daily for 7 days to excision‐type cutaneous wounds in rats led to increased enzymatic and non‐enzymatic antioxidants, namely superoxide dismutase (35%), catalase (67%), glutathione peroxidase (49%), vitamin E (77%) and ascorbic acid (36%) in newly formed tissues. It also resulted in a several fold decrease in lipid peroxide levels (69%) as measured in terms of thiobarbituric acid reactive substance. However, continued application for 14 days showed no significant difference in these antioxidants compared with their values in vehicle treated wound tissue. It appears from the present study that asiaticosides enhanced induction of antioxidant levels at an initial stage of healing which may be an important contributory factor in the healing properties of this substance. Copyright © 1999 John Wiley & Sons, Ltd.

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“…1(a)], a trisaccharide triterpene, is supposed to be the most active compound associated with the healing of wounds. This is evidenced by the observed increase in antioxidant levels at an initial stage of the healing of excision‐type cutaneous wounds in rats,20 the observed increase in the proliferation and the production of types I and III pro‐collagen mRNAs and the levels of the corresponding proteins of human dermal fibroblasts,23–26 and the stimulation of ECM accumulation in murine experimental wounds 22, 24. Curcumin (CM) [see chemical structure in Fig.…”

Section: Introductionmentioning

confidence: 97%

In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin

Suwantong

Ruktanonchai

Supaphol

2010

J Biomedical Materials Res

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Ultra-fine cellulose acetate (CA; M(w) approximately 30,000 Da; degree of acetyl substitution approximately 2.4) fiber mats containing either asiaticoside [from the plant Centella asiatica (L.); either in the form of a crude extract (CACE) or pure substance (PAC)] or curcumin (CM; from the plant Curcuma longa L.) were successfully prepared. The proposed use of these materials is as topical/transdermal patches or wound dressings. Here, the potential for use of these herb-loaded CA fiber mats as wound dressings was evaluated in terms of the stability and the antioxidant activity of the as-loaded herbal substances, the ability to support both the attachment and the proliferation of fibroblasts and the ability of the cultured fibroblasts to synthesize collagen. Normal human dermal fibroblasts (NHDF) were used as the reference fibroblastic cells. The results showed that the as-loaded herbal substances were stable even after the herb-loaded CA fiber mats had been aged either at room temperature or at 40 degrees C for a period of up to 4 months. The inclusion of asiaticoside [either 2% (w/w) CACE or 40% (w/w) PAC] rendered the resulting CA fiber mats their superiority in supporting the attachment, promoting the proliferation, and upregulating the production of collagen of the seeded and/or the cultured NHDF to the corresponding solvent-cast films and the neat CA fiber mats. On the other hand, the presence of CM imparted the antioxidant activity to the resulting CA fiber mats.

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Asiaticoside mimetics as wound healing agent

Cited by 20 publications

References 9 publications

Electrospun cellulose acetate fiber mats containing asiaticoside or Centella asiatica crude extract and the release characteristics of asiaticoside

Electrospun cellulose acetate fiber mats containing asiaticoside or Centella asiatica crude extract and the release characteristics of asiaticoside

Asiaticoside-induced elevation of antioxidant levels in healing wounds

In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin

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