Asociación del índice neutrófilo-linfocito y el estadio clínico en el diagnóstico inicial de melanoma

Limas, Christian Patricio Camacho; Cwilich, Raquel Gerson; Jurado, María del Angel Góngora; Naveda, Marcos López

doi:10.1016/j.gamo.2016.08.002

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…The role of neutrophils have been described in various cancer types, including colorectal cancer ( 44 , 45 ), glioblastoma ( 46 ), hepatocellular carcinoma ( 47 ), renal cell carcinoma ( 48 ), melanoma ( 49 , 50 ), pancreatic ductal carcinoma ( 51 ), and head and neck cancer ( 52 ). Some studies have shown that increased number of neutrophils in tumor tissue or elevated ratio of neutrophil vs. lymphocyte in peripheral blood is associated with a poor prognosis of cancer patients ( 45 – 49 , 51 , 52 ).…”

Section: The Dual Roles Of Neutrophils In Cancersmentioning

confidence: 99%

Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases

et al. 2018

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Neutrophils are one of the first immune cell types that are recruited to injury and infection site. As a vital component of the immune system, neutrophils are heterogeneous immune cells known to have phagocytic property and function in inflammation. Recent studies revealed that neutrophils play dual roles in tumor initiation, development, and progression. The multifunctional roles of neutrophils in diseases are mainly due to their production of different effector molecules under different conditions. N1 and N2 neutrophils or high density neutrophils (HDNs) and low density neutrophils (LDNs) have been used to distinguish neutrophils subpopulations with pro- vs. anti-tumor activity, respectively. Indeed, N1 and N2 neutrophils also represent immunostimulating and immunosuppressive subsets, respectively, in cancer. The emerging studies support their multifaceted roles in autoimmune diseases. Although such subsets are rarely identified in autoimmune diseases, some unique subsets of neutrophils, including low density granulocytes (LDGs) and CD177+ neutrophils, have been reported. Given the heterogeneity and functional plasticity of neutrophils, it is necessary to understand the phenotypical and functional features of neutrophils in disease status. In this article, we review the multifaceted activates of neutrophils in cancer and autoimmune diseases, which may support new classification of neutrophils to help understand their important functions in immune homeostasis and pathologies.

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Section: The Dual Roles Of Neutrophils In Cancersmentioning

confidence: 99%

Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases

et al. 2018

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Impact on Survival with Immunotherapy and Evaluation of Biomarkers in Peruvian Patients with Advanced Melanoma

Valencia,

Roque,

Rioja

et al. 2024

OTT

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Introduction Advanced malignant melanoma is a very aggressive disease, historically with poor prognosis before the new advances with immunotherapy and targeted therapies that have changed the standard of care, especially in cutaneous melanoma. Peru has aggressive features such as higher rates of acral lentiginous melanoma (ALM) subtype with historically shorter survival. Methods This study describes Peruvian patients with advanced melanoma treated with immunotherapy (nivolumab) in two oncological institutions (public and private), including the discussion of the impact on overall survival (OS) divided by subtype (with incidence in ALM histology) and potential biomarkers that could be related to prognosis. Results We found that immunotherapy is safe, and improves progression-free survival (PFS), OS and objective response rate (ORR) in our patients, with lower benefit in ALM histology. No prognostic blood inflammatory biomarkers were detected. Discussion There is very limited data of Peruvian patients with metastatic melanoma treated with immunotherapy, especially the outcomes in ALM histology. Our goal is to share an example of the impact of immunotherapy in a Latin American (LATAM) population considered as an unsatisfied group with an enormous need of novel treatments and biomarkers.

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Asociación del índice neutrófilo-linfocito y el estadio clínico en el diagnóstico inicial de melanoma

Cited by 2 publications

References 19 publications

Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases

Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases

Impact on Survival with Immunotherapy and Evaluation of Biomarkers in Peruvian Patients with Advanced Melanoma

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