Aspectos epidemiológicos de la brucelosis en humanos en las Áreas Rectoras Aguas Zarcas y Los Chiles, Costa Rica, 2015-2017

Galeano, Claudia Rosales; Mojica, Claudia Puentes; Rojas, Oldemar Arias; Romero-Zúñiga, Juan José

doi:10.15359/rcv.38-1.1

Cited by 3 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2015, a randomized trial carried out in Costa Rica’s Huetar Norte Region (170 inhabitants) found human brucellosis prevalence at 12.5% among rural at-risk people. A Ministry of Health report confirmed that 144 human brucellosis cases had been reported for the entire country (at the time having 4.5 million inhabitants) but there had been only eight reported for the same northern region [ 68 ]. Additionally, inconsistent numbers have also been found in Colombia and Mexico [ 69 , 70 ], as well as other countries [ 71 ] that provide a similar picture.…”

Section: Prevalence Of Human Brucellosismentioning

confidence: 99%

The Development of Diagnostic and Vaccine Strategies for Early Detection and Control of Human Brucellosis, Particularly in Endemic Areas

et al. 2023

View full text Add to dashboard Cite

Brucellosis is considered one of the most serious zoonotic diseases worldwide. This disease affects both human and animal health, in addition to being one of the most widespread zoonotic illnesses in the Middle East and Northern Africa. Human brucellosis generally presents in a diverse and non-specific manner, making laboratory confirmation of the diagnosis critical to the patient’s recovery. A coordinated strategy for diagnosing and controlling brucellosis throughout the Middle East is required, as this disease cannot be known to occur without reliable microbiological, molecular, and epidemiological evidence. Consequently, the current review focuses on the current and emerging microbiological diagnostic tools for the early detection and control of human brucellosis. Laboratory assays such as culturing, serology, and molecular analysis can frequently be used to diagnose brucellosis. Although serological markers and nucleic acid amplification techniques are extremely sensitive, and extensive experience has been gained with these techniques in the laboratory diagnosis of brucellosis, a culture is still considered to be the “gold standard” due to the importance of this aspect of public health and clinical care. In endemic regions, however, serological tests remain the primary method of diagnosis due to their low cost, user-friendliness, and strong ability to provide a negative prediction, so they are commonly used. A nucleic acid amplification assay, which is highly sensitive, specific, and safe, is capable of enabling rapid disease diagnosis. Patients who have reportedly fully healed may continue to have positive molecular test results for a long time. Therefore, cultures and serological methods will continue to be the main tools for diagnosing and following up on human brucellosis for as long as no commercial tests or studies demonstrate adequate interlaboratory reproducibility. As there is no approved vaccine that prevents human brucellosis, vaccination-based control of animal brucellosis has become an important part of the management of human brucellosis. Over the past few decades, several studies have been conducted to develop Brucella vaccines, but the problem of controlling brucellosis in both humans and animals remains challenging. Therefore, this review also aims to present an updated overview of the different types of brucellosis vaccines that are currently available.

show abstract

Section: Prevalence Of Human Brucellosismentioning

confidence: 99%

The Development of Diagnostic and Vaccine Strategies for Early Detection and Control of Human Brucellosis, Particularly in Endemic Areas

et al. 2023

View full text Add to dashboard Cite

show abstract

“…However, when the figures of both sources are contrasted with field studies, it becomes evident that a significant proportion of the official data lacks precision. For example, while a randomized study in a rural at-risk population in the Huetar Norte Region of Costa Rica (170 inhabitants) estimated the human brucellosis prevalence at 12.5% (the year 2015), the Ministry of Health reported a total of 144 human brucellosis cases for the whole country (then with 4.5 million inhabitants), and only eight cases for the same northern region [ 69 ]. Similarly, discordant figures have been found in countries such as Colombia and México [ 70 , 71 ] and elsewhere [ 14 ].…”

Section: The Conundrums Of Human Brucellosismentioning

confidence: 99%

Facing the Human and Animal Brucellosis Conundrums: The Forgotten Lessons

2022

View full text Add to dashboard Cite

Brucellosis is a major zoonotic disease caused by Brucella species. Historically, the disease received over fifty names until it was recognized as a single entity, illustrating its protean manifestations and intricacies, traits that generated conundrums that have remained or re-emerged since they were first described. Here, we examine confusions concerning the clinical picture, serological diagnosis, and incidence of human brucellosis. We also discuss knowledge gaps and prevalent confusions about animal brucellosis, including brucellosis control strategies, the so-called confirmatory tests, and assumptions about the primary-binding assays and DNA detection methods. We describe how doubtfully characterized vaccines have failed to control brucellosis and emphasize how the requisites of controlled safety and protection experiments are generally overlooked. Finally, we briefly discuss the experience demonstrating that S19 remains the best cattle vaccine, while RB51 fails to validate its claimed properties (protection, differentiating infected and vaccinated animals (DIVA), and safety), offering a strong argument against its current widespread use. These conundrums show that knowledge dealing with brucellosis is lost, and previous experience is overlooked or misinterpreted, as illustrated in a significant number of misguided meta-analyses. In a global context of intensifying livestock breeding, such recurrent oversights threaten to increase the impact of brucellosis.

show abstract

“…Sin embargo, existen otras vías de infección como la respiratoria (inhalación de polvo, pelo, excretas de animales infectados), cutánea y conjuntival (contacto directo con material contaminado). De modo que la asistencia en los partos, faena de animales y limpieza de los utensilios, máquinas y vertederos son las actividades más involucradas en la transmisión del patógeno (6,8) .…”

Section: Introductionunclassified

“…Entre ellas, se encuentran las pruebas tamiz como Rosa de Bengala y Huddleson, siendo las más empleadas para detectar inmunoglobulinas M y G contra la Brucella sp. (8) .…”

Section: Introductionunclassified

Seroprevalencia de anticuerpos contra la Brucella sp . en ganaderos del distrito San José de Lourdes, Cajamarca

Julcahuanca

Pérez

Cruz-López

et al. 2021

revista de salud udh

View full text Add to dashboard Cite

Objetivo. Determinar la seroprevalencia de anticuerpos contra la Brucella sp. e identifcar los factores predisponentes y la sintomatología asociada en los ganaderos del distrito San José de Lourdes (San Ignacio) en el departamento de Cajamarca, durante los meses de setiembre a diciembre del 2019. Métodos. El estudio fue de tipo observacional, transversal, prospectivo con un diseño exploratorio-descriptivo. Se realizó un muestreo probabilístico, donde se analizaron 147 sueros sanguíneos pertenecientes a ganaderos de ambos géneros. La seroprevalencia de anticuerpos se determinó mediante las pruebas Rosa de Bengala y antígeno de Huddleson y se aplicó una encuesta estructurada para identifcar los factores predisponentes y la sintomatología asociada a la enfermedad. Resultados. Se encontró que, 17 % de ganaderos seropositivos a Brucella sp. mantuvo contacto directo prolongado con el ganado bovino (p < 0,05). Además, el 23,8 % de ganaderos presentó anticuerpos contra la Brucella sp, siendo principalmente mujeres (15,6 %). Los ganaderos con anticuerpos contra la Brucella sp. consumían queso (22,4 %), leche (19,7 %) y sangre de animales sacrifcados (17 %) (p > 0,05). Los síntomas más recurrentes fueron el dolor de cabeza (19 %), fatiga (14,3 %), dolor articular (13,6 %), febre e insomnio (10,2 %). Conclusión. La seroprevalencia de anticuerpos contra la Brucella sp. es alta y está asociada al contacto directo prolongado con el ganado bovino y a síntomas como el dolor de cabeza y la febre, presentes en la población evaluada. Los resultados obtenidos permiten evidenciar la preocupante situación que viven los ganaderos de San José de Lourdes, además de la escasa cultura preventiva existente.

show abstract

Aspectos epidemiológicos de la brucelosis en humanos en las Áreas Rectoras Aguas Zarcas y Los Chiles, Costa Rica, 2015-2017

Cited by 3 publications

References 17 publications

The Development of Diagnostic and Vaccine Strategies for Early Detection and Control of Human Brucellosis, Particularly in Endemic Areas

The Development of Diagnostic and Vaccine Strategies for Early Detection and Control of Human Brucellosis, Particularly in Endemic Areas

Facing the Human and Animal Brucellosis Conundrums: The Forgotten Lessons

Seroprevalencia de anticuerpos contra la Brucella sp . en ganaderos del distrito San José de Lourdes, Cajamarca

Contact Info

Product

Resources

About