Aspergillus Infections After Lung Transplantation

Day, Larry; Chenoweth, Carol E.; Hyde, Kristi Vander; Lynch, Joseph P.; Iannettoni, Mark D.; Clark, Nina M.

doi:10.1097/01.idc.0000230548.96251.70

Cited by 5 publications

(1 citation statement)

References 36 publications

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“…The reported incidence of AT in lung transplants (3.6–5%) is much higher than in other solid organ transplants (SOTs) (5, 10). This fact has been related to organisms having direct access to the airways and the more potent immunosuppression received by lung recipients (5, 11, 12). The favorable outcome of AT frequently observed in lung transplant patients is related to an early diagnosis based on surveillance bronchoscopies scheduled to rule out rejection (5, 13, 14).…”

Section: Discussionmentioning

confidence: 99%

PseudomembranousAspergillustracheobronchitis in a heart transplant recipient

Ramos

Segovia

Gómez‐Bueno

et al. 2010

Transplant Infectious Disease

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Aspergillus tracheobronchitis (AT) is an uncommon clinical presentation of pulmonary aspergillosis that frequently progresses to invasive pulmonary aspergillosis. Diagnosis of AT may be delayed because of its insidious onset, non-specific signs and symptoms, and scarcity of radiographic abnormalities. We report the case of a patient who received a heart transplant (HT) because of cardiac amyloidosis and who developed pseudomembranous AT. Possible risk factors concurrent in this case were splenectomy, lymphocytopenia, and previous cytomegalovirus infection. Chest computed tomography scan showed thickening of the left bronchi and a 'tree-in-bud' pattern with multiple small nodules. Bronchoscopic examination revealed raised yellowish pseudomembranous plaques on the tracheobronchial tree. Bronchoalveolar lavage and aspirate cultures yielded Aspergillus fumigatus. The patient recovered with voriconazole. Clinicians should be aware of AT as a potential cause of respiratory symptoms with few radiographic abnormalities in HT recipients, as delay in performing bronchoscopy could result in an unfavorable prognosis.

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Section: Discussionmentioning

confidence: 99%