2016
DOI: 10.1007/s00405-016-4273-1
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Aspirin-exacerbated respiratory disease and current treatment modalities

Abstract: Aspirin-exacerbated respiratory disease (AERD) refers to the combination of asthma, chronic rhinosinusitis with nasal polyposis, and acute upper and lower respiratory tract reactions to the ingestion of aspirin (acetylsalicylic acid, ASA) and other cyclooxygenase-1 inhibiting non-steroidal anti-inflammatory drugs. AERD affects 0.3-0.9 % of the general population. AERD generally occurs due to abnormalities in mediators and expression of arachidonic acid biosynthesis. Local IgE responses to staphylococcal entero… Show more

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Cited by 34 publications
(31 citation statements)
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“…Despite the significant importance of disturbances in the metabolism of arachidonic acid leading to the overproduction of proinflammatory CysLTs, drugs blocking receptor or leukotriene C4 synthase (LTC4S) are not recommended [1]. This is in contradiction with reports from the literature [3, 6, 8, 12, 16]. The last update of the ARIA document (Allergic Rhinitis and its Impact on Asthma) from 2016 allows to use antileukotrienes (LTRAs) as a supplement to therapy, especially in patients with asthma, in the case of seasonal allergic rhinitis [22].…”
Section: Discussioncontrasting
confidence: 54%
See 1 more Smart Citation
“…Despite the significant importance of disturbances in the metabolism of arachidonic acid leading to the overproduction of proinflammatory CysLTs, drugs blocking receptor or leukotriene C4 synthase (LTC4S) are not recommended [1]. This is in contradiction with reports from the literature [3, 6, 8, 12, 16]. The last update of the ARIA document (Allergic Rhinitis and its Impact on Asthma) from 2016 allows to use antileukotrienes (LTRAs) as a supplement to therapy, especially in patients with asthma, in the case of seasonal allergic rhinitis [22].…”
Section: Discussioncontrasting
confidence: 54%
“…SNIDR/NIDHR is based on the participation of immunological mechanisms belonging to type IV reactions, in which cytotoxic T lymphocytes play the main role [15]. In the literature, the prevalence of hypersensitivity to NSAIDs is within 0.3–0.9% of the population, increasing to 40% among asthmatics with CRSwNP [16]. Meta-analysis of the literature performed by Rajan et al [13] in 2014 suggests that the prevalence of NERD in patients with asthma is 14.89%, of those with CRSwNP 9.69%, and of those with CRSsNP 8.7%.…”
Section: Introductionmentioning
confidence: 99%
“…15 Interestingly, according to the available literature, all histological changes in the upper airway related to nickel and copper dust inhalation are situated in the nasal epithelium. 13,14 We suggest that precancerous changes may occasionally be noted in inflammatory NPs, especially in workers exposed to heavy metals, a fact that both rhinologists and pathologists should keep in mind.…”
Section: Discussionmentioning
confidence: 94%
“…Nasal polyposis as a part of AERD is one of the most severe form of chronic rhinosinusitis, where both the subepithelium and epithelium are strongly affected by toxic mediators released from mast cells and eosinophils during the chronic inflammatory process, especially by leukotrienes and eosinophilic enzymes. 13 Mechanisms for epithelial metaplasia and dysplasia in workers exposed to nickel and copper dust salt are not well investigated. A multitude of factors seems to contribute to the transformation of respiratory nasal epithelium to squamous epithelium.…”
Section: Discussionmentioning
confidence: 99%
“…The presence of bronchial asthma, chronic rhinosinusitis (CRS) with nasal polyps, and a hypersensitivity reaction of the airway to aspirin (acetylsalicylic acid-ASA), as well as other non-selective inhibitors of the cyclooxygenase enzyme (COX), [1][2][3] commonly characterizes the Aspirin-exacerbated respiratory disease (AERD). It is within the broad spectrum of hypersensitivity reactions induced by non-steroidal anti-inflammatory drugs (NSAIDs), in minutes after administration.…”
Section: Introductionmentioning
confidence: 99%