2009
DOI: 10.1016/j.homp.2009.09.005
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Assays of homeopathic remedies in rodent behavioural and psychopathological models

Abstract: The first part of this paper reviews the effects of homeopathic remedies on several models of anxiety-like behaviours developed and described in rodents. The existing literature in this field comprises some fifteen exploratory studies, often published in non-indexed and non-peer-reviewed journals. Only a few results have been confirmed by multiple laboratories, and concern Ignatia, Gelsemium, Chamomilla (in homeopathic dilutions/potencies). Nevertheless, there are some interesting results pointing to the possi… Show more

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Cited by 42 publications
(52 citation statements)
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“…This implies that a homeopathic remedy must be chosen by taking into consideration the organism as a whole, including personality and behaviour, and not merely the symptoms in the affected organ system. Solid statistical evidence demonstrates that the effects of the different potency levels investigated (5CH, 7CH, 30CH) do not follow a classical dose-response relationship regarding their mere dilution level, confirming a phenomenon frequently observed with high homeopathic dilutions in other laboratory models [30] . In our study the symptoms of two horses (horse 8, 10) with circling were reduced considerably but not completely disappeared.…”
Section: Discussionsupporting
confidence: 68%
“…This implies that a homeopathic remedy must be chosen by taking into consideration the organism as a whole, including personality and behaviour, and not merely the symptoms in the affected organ system. Solid statistical evidence demonstrates that the effects of the different potency levels investigated (5CH, 7CH, 30CH) do not follow a classical dose-response relationship regarding their mere dilution level, confirming a phenomenon frequently observed with high homeopathic dilutions in other laboratory models [30] . In our study the symptoms of two horses (horse 8, 10) with circling were reduced considerably but not completely disappeared.…”
Section: Discussionsupporting
confidence: 68%
“…9 Again other researchers notably Bellavite's group have used a similar method, although with different homeopathic medicines, and reported broadly similar results. 10 So in these two areas there is the beginning of a replicated body of literature.…”
Section: Inflammation Andanxietymodelsmentioning
confidence: 99%
“…Raw alcoholic extracts from Gelsemium sempervirens showed the ability to modify the response of mice in behavioural tests and reduce anxiety [15]. In this research, the anxiolytic property related to Gelsemium extracts has been quite exclusively associated with the alkaloid gelsemine [13, 15, 16]; yet, Gelsemium plants contain many further alkaloids with anxiolytic potential [12], thus suggesting that the anti-anxiety activity of Gelsemium sempervirens may come indifferently from gelsemine, koumine, or gelsevirine or a complex mixture of several active alkaloids [13]. Actually, plants from the genus Gelsemium are considered a source of potential anxiolytic substances [12].…”
Section: Introductionmentioning
confidence: 99%
“…Gelsemine was supposed to be the only active principle working in Gelsemium extracts on the simple basis of previous in vitro pharmacological evidence• BIAS 4. Adverse effects not evaluatedSolvent and test samples Gelsemium extracts were used as a 30 % EtOH/water mixture and further diluted with EtOH and water to have test samples[1416, 20, 21]A [8, 9, 18]B [10, 19]• BIAS 5. Refs [15, 16, 20, 21] started from a raw EtOH/H2O Gelsemium extract containing 30 % alcohol (~50 mM EtOH), then a 1:100 dilution into water with 30 % EtOH and a 1.100 dilution into water (1:10,000) followed.…”
Section: Introductionmentioning
confidence: 99%