Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens Using a Coaligned Ultrasound and Optical Coherence Elastography System

Wu, Chen; Han, Zhaolong; Wang, Shang; Li, Jiasong; Singh, Manmohan; Liu, Chih-Hao; Aglyamov, Salavat R.; Emelianov, Stanislav; Manns, Fabrice; Larin, Kirill V.

doi:10.1167/iovs.14-15654

Cited by 96 publications

(76 citation statements)

References 42 publications

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“…However, for imaging tissues in situ both ultrasound stimulation and OCT beam are preferable to be on the same side. Such design was incorporated in our recent work to assess the age-related changes in the biomechanical properties of the crystalline lens in situ (Wu et al, 2015). …”

Section: Results and Disscussionmentioning

confidence: 99%

“…The radiation force can be generated not only inside the tissue but also at the tissue surface or at the tissue boundaries where there is a significant difference in the acoustic impedance. Tissue excitation and surface deformation measurements have been used in elastography of skin (Li et al, 2012a, Li et al, 2012b, Coutts et al, 2006, Kirkpatrick et al, 2006), cornea (Tanter et al, 2009, Twa et al, 2014), crystalline lens (Wang et al, 2013, Manapuram et al, 2011, Wu et al, 2015), bladder wall (Li et al, 2014, Nenadic et al, 2013) and other potential applications (Sarvazyan, 2010). However, in all of these applications, the depth inhomogeneity of the tissue plays an important role in its mechanical response.…”

Section: Introductionmentioning

confidence: 99%

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The dynamic deformation of a layered viscoelastic medium under surface excitation

et al. 2015

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In this study the dynamic behavior of a layered viscoelastic medium in response to the harmonic and impulsive acoustic radiation force applied to its surface was investigated both theoretically and experimentally. An analytical solution for a layered viscoelastic compressible medium in frequency and time domains was obtained using the Hankel transform. A special incompressible case was considered to model soft biological tissues. To verify our theoretical model, experiments were performed using tissue-like gel-based phantoms with varying mechanical properties. A 3.5 MHz single-element focused ultrasound transducer was used to apply the radiation force at the surface of the phantoms. A phase-sensitive optical coherence tomography (OCT) system was used to track the displacements of the phantom surface. Theoretically predicted displacements were compared with experimental measurements. The role of the depth dependence of the elastic properties of a medium in its response to an acoustic pulse at the surface was studied. It was shown that the low-frequency vibrations at the surface are more sensitive to the deep layers than high-frequency ones. Therefore, the proposed model in combination with spectral analysis can be used to evaluate depth-dependent distribution of the mechanical properties based on the measurements of the surface deformation.

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Section: Results and Disscussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The dynamic deformation of a layered viscoelastic medium under surface excitation

et al. 2015

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“…In temporal analysis methods, an external stimulus is used to remotely induce a displacement in the sample, and a phase-sensitive method, typically co-focused with the stimulus, is utilized to monitor the localized temporal response of surface deformations. Again, spectral decomposition can be used to quantify the viscoelasticity of the measured position [64,191], as well as the depth-resolved viscoelasticity [64]. Wu et al showed that spectral analysis of the displacement response of rabbit crystalline lenses of different ages in response to ARF in situ could reconstruct the lens viscoelasticity [191].…”

Section: Surface Elastic Wave Methods and Applicationsmentioning

confidence: 99%

“…Again, spectral decomposition can be used to quantify the viscoelasticity of the measured position [64,191], as well as the depth-resolved viscoelasticity [64]. Wu et al showed that spectral analysis of the displacement response of rabbit crystalline lenses of different ages in response to ARF in situ could reconstruct the lens viscoelasticity [191]. Expanding upon the displacement response spectral analysis, Wang et al showed the feasibility of a utilizing the surface temporal displacement profile to distinguish layered phantoms [87], which, when combined with an analytical model [64], could provide the depth-resolved viscoelasticity distribution from only the surface temporal profile.…”

Section: Surface Elastic Wave Methods and Applicationsmentioning

confidence: 99%

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin

Sampson

2017

Biomed. Opt. Express

368

258

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Abstract:Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography -the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published in 2015, and more than 25 in 2016, OCE is growing fast, but still small compared to the companion fields of cell mechanics research methods, and medical elastography. In this review, we describe the early developments in OCE, and the factors that led to the current acceleration. Much of our attention is on the key recent advances, with a strong emphasis on future prospects, which are exceptionally bright.

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“…In an optical coherence elastography (OCE) application, the OCT unit is used for detection of elastic vibration, and different excitation sources are employed to generate an elastic wave in soft materials, including non-contact focused air-puff device [9,10] and ultrasonic transducer [11–14], and contact mechanical wave driver [15] and piezoelectric actuator [16,17]. The noncontact air-puff device has conveniently detected the elastic modulus of the cornea [9].…”

mentioning

confidence: 99%

Imaging and characterizing shear wave and shear modulus under orthogonal acoustic radiation force excitation using OCT Doppler variance method

Zhu

et al. 2015

Opt. Lett.

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We report on a novel acoustic radiation force orthogonal excitation optical coherence elastography (ARFOE-OCE) technique for imaging shear wave and quantifying shear modulus under orthogonal acoustic radiation force (ARF) excitation using the optical coherence tomography (OCT) Doppler variance method. The ARF perpendicular to the OCT beam is produced by a remote ultrasonic transducer. A shear wave induced by ARF excitation propagates parallel to the OCT beam. The OCT Doppler variance method, which is sensitive to the transverse vibration, is used to measure the ARF-induced vibration. For analysis of the shear modulus, the Doppler variance method is utilized to visualize shear wave propagation instead of Doppler OCT method, and the propagation velocity of the shear wave is measured at different depths of one location with the M scan. In order to quantify shear modulus beyond the OCT imaging depth, we move ARF to a deeper layer at a known step and measure the time delay of the shear wave propagating to the same OCT imaging depth. We also quantitatively map the shear modulus of a cross-section in a tissue-equivalent phantom after employing the B scan.

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Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens Using a Coaligned Ultrasound and Optical Coherence Elastography System

Abstract: The results demonstrate that the US-OCE system can be used for noninvasive analysis and quantification of lens biomechanical properties in situ and possibly in vivo.

Cited by 96 publications

References 42 publications

The dynamic deformation of a layered viscoelastic medium under surface excitation

The dynamic deformation of a layered viscoelastic medium under surface excitation

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Imaging and characterizing shear wave and shear modulus under orthogonal acoustic radiation force excitation using OCT Doppler variance method

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