2014
DOI: 10.1016/j.vascn.2013.12.005
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Assessing anxiety in C57BL/6J mice: A pharmacological characterization of the open-field and light/dark tests

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Cited by 78 publications
(57 citation statements)
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“…CDP had no effect on any behavior in the EZM. These results replicate previous studies that report insensitivity of B6 mice to the anxiolytic-like effects of CDP using the same behavioral assays (Heredia et al, 2013a;Heredia et al, 2013b;Mathiasen et al, 2008) although others have reported anxiolytic effects in both the EPM and LD assays (Belzung and Dubreuil, 1998;Crawley and Goodwin, 1980;Smith et al, 2012). It should be noted that there might be strain-specific effects that were not assessed since we focused our studies in the EPM, EZM and LD on B6 mice to provide a comprehensive assessment of this commonly used inbred strain.…”
Section: Discussionsupporting
confidence: 88%
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“…CDP had no effect on any behavior in the EZM. These results replicate previous studies that report insensitivity of B6 mice to the anxiolytic-like effects of CDP using the same behavioral assays (Heredia et al, 2013a;Heredia et al, 2013b;Mathiasen et al, 2008) although others have reported anxiolytic effects in both the EPM and LD assays (Belzung and Dubreuil, 1998;Crawley and Goodwin, 1980;Smith et al, 2012). It should be noted that there might be strain-specific effects that were not assessed since we focused our studies in the EPM, EZM and LD on B6 mice to provide a comprehensive assessment of this commonly used inbred strain.…”
Section: Discussionsupporting
confidence: 88%
“…However, the OF that was designed for and validated in rats has been transferred to mice to take advantage of advances in genetic and genomic tools. Our observation that CDP failed to increase center time in B6 mice in the OF was surprising, if not completely unexpected based on studies in which no effect or the opposite effect has been observed (Heredia et al, 2013a;Seredenin et al, 1990). However, a confirmation of the CDP-induced behavioral results using a different benzodiazepine, DZ, led us to start considering potential factors that might explain the lack of validation in B6 mice.…”
Section: Discussionsupporting
confidence: 74%
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“…The open-field test is used to measure anxiety based on the spontaneous behavior of the animals. The distance traveled in the open-field is typically interpreted as an activity-like measure while the tendency to avoid the central area is an indicator of anxiety-like behavior, based on the assumption that the central area is more threatening for rodents than the peripheral area (Heredia et al, 2014). In this study, mice administered taurine zinc spent more time in the central area and traveled a longer distance than the control mice, suggesting that taurine zinc effectively attenuated the level of anxiety in mice facing a novel environment, thus increasing their locomotor activity.…”
Section: Discussionmentioning
confidence: 99%
“…The distance traveled in the open-field is typically interpreted as an activity-like measure and the tendency of mice to avoid the central area is an indicator of anxiety-like levels, under the assumption that the central area is more threatening for rodents than the peripheral area (Heredia et al, 2014). …”
Section: Open Field Testmentioning
confidence: 99%