Assessing fertility in women of advanced reproductive age

Klein, J.; Sauer, Mark V.

doi:10.1067/mob.2001.114689

Cited by 111 publications

(72 citation statements)

References 120 publications

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“…Em média, 8 a 10% dos casais em idade reprodutiva apresentam dificuldade de engravidar 1 . Entre os casais inférteis, os fatores masculinos e femininos, isoladamente, são responsáveis por cerca de 35% dos casos; a associação dos fatores anteriores, por 20%; e, em cerca de 10% dos casos, não é diagnosticado um fator responsável 2 .…”

Section: Introductionunclassified

Interferência da idade sobre a qualidade seminal

Cavalcante¹,

Rocha²,

Dias³

et al. 2008

Rev. Bras. Ginecol. Obstet.

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XLSTAT (p<0,05). RESULTADOS: os indivíduos estudados tinham média de idade de 37±7,9 anos, com um volume seminal médio de 3±1,4 mL, uma concentração espermática de 61,4±66,4 espermatozóides por mL de sêmen, motilidade progressiva de 44,7±19,4% do total de espermatozóides e morfologia normal de 11,2±6,6% dos espermatozóides. As médias de idade entre os grupos foram semelhantes, exceto a média dos indivíduos com hipoespermia, que foi significativamente maior que a dos homens com normoespermia (39,6±10,3 versus 36,5±7,3, p=0,001). CONCLUSÕES: a idade interfere, de forma inversamente proporcional, sobre o volume do ejaculado, porém não exerce influência na concentração, motilidade e morfologia espermática.Abstract PURPOSE: to evaluate the influence of age on the quality of semen in men submitted to spermatic analysis in a human reproduction service, in cases of conjugal infertility. METHODS: a retrospective study in which the spermiograms of all men in process of investigation for conjugal infertility in a service of assisted reproduction in the Northeast of Brazil were evaluated from September 2002 to December 2004. A number of 531 individuals submitted to 531 spermatic evaluations were included in the study. The following parameters have been analyzed: spermatic volume, concentration, motility and morphology. The men under investigation have been divided in groups, according to the results obtained in each of the variables studied. Seminal volume groups were divided in: hypospermia, normospermia and hyperspermia. Spermatic concentration groups were divided in: azoospermia, oligospermia, normospermia and polyspermia. Motility groups were divided in: normal motility and asthenospermia. Morphology groups were divided in: normal morphology and teratospermia. The t test has been used to compare the average age of patients in groups with normal and in groups with altered parameters. The program XLSTAT (p<0.05) has been used for the statistical analysis. RESULTS: the individuals studied presented an average of 37±7.9 years old, with an average of seminal volume of 3±1.4 mL, a spermatic concentration of 61.4±66.4 spermatozoids by mL of semen, a progressive motility of 44.7±19.4% of the total of spermatozoids and normal morphology of 11.2±6.6% of the spermatozoids.

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Section: Introductionunclassified

Interferência da idade sobre a qualidade seminal

Cavalcante¹,

Rocha²,

Dias³

et al. 2008

Rev. Bras. Ginecol. Obstet.

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“…The situation in human is more complicated [37], much debate exists whether ovarian or uterine factors are primarily responsible for the age-related decline in fertility. The IVF and donor egg programs has provided a more direct means of investigating the relative contribution of the uterus and oocyte to human reproductive senescence.…”

Section: Uterine Aging Contributes To Decreased Reproductive Capacitymentioning

confidence: 99%

Determinants of uterine aging: lessons from rodent models

Kong

Zhang

Chen

et al. 2012

Sci. China Life Sci.

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The uterus is an indispensable organ for the development of a new life in eutherian mammals. The female mammalian reproductive capacity diminishes with age. In this respect, the senescence of uterine endometrium is convinced to contribute to this failure. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans. . More importantly, this phenomenon of continuous decline of fecundity with age has also been confirmed in women over 35 years old [10][11][12]. The success of reproduction in eutherian mammals requires the uterus, a unique organ in the viviparity compared to other organisms ensuring full development of the new life in the maternal body [13]. The endometrial environment of uteri is proved to be one of the critical aspects to determine the reproductive capacity [14] and uterine factor has been proved to be critical for the decline of fecundity in both rodents and humans [4,15]. Most of the available information on uterine aging derives from studies on rats and mice [16]. In these species, life span is short and aging animal model can be easily established. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. determinants, uterine aging, rodent models

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“…Reduced fertility in aging women is primarily due to 'ovarian aging' with reduced quality and reduced numbers of oocytes (decreased ovarian reserve) as well as an altered hormonal environment leading to ovulatory dysfunction. No abrupt and clear cutoff level can be defined, but rather a slow steady decline is seen between the ages of 20 and 37 years followed by an accelerated decline over subsequent years, so that spontaneous conceptions and deliveries after the age of 45 are rare, although there are population groups (like Bedouins) with the ability to conceive and deliver at later ages (Menken et al, 1986;Klein and Sauer, 2001;Laufer et al, 2004;Gielchinsky et al, 2006).…”

Section: Paternal Age and Fertilitymentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

291

212

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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Assessing fertility in women of advanced reproductive age

Cited by 111 publications

References 120 publications

Interferência da idade sobre a qualidade seminal

Interferência da idade sobre a qualidade seminal

Determinants of uterine aging: lessons from rodent models

Paternal age and reproduction

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