Assessment of 1,25-dihydroxyvitamin D3 effects on Treg cells in a mouse model of systemic lupus erythematosus

Arab, Fahimeh Lavi; Rastin, Maryam; Faraji, Fatemeh; Rabe, Shahrzad Zamani Taghizadeh; Tabasi, Nafise; Khazaee, Mahdieh; Haghmorad, Dariush; Mahmoudi, Mahmoud

doi:10.3109/08923973.2014.968255

Cited by 29 publications

(16 citation statements)

References 34 publications

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“…Our results demonstrated that, in addition to enhancing the number of CD4 + CD25 high Foxp3 + Treg cells, vitamin D treatment increased the expression levels of Foxp3 and TGFβ, while it decreased the expression of IL6. These results are compatible with previously published studies (Jeffery et al, 2009;Kang, Kim, Lee, Kang, & Lee, 2010;Kang et al, 2012;Lavi Arab et al, 2014). Increased levels of TGFβ can positively affect the expression of Foxp3 (Mahon, Gordon, Cruz, Cosman, & Cantorna, 2003).…”

Section: Discussionsupporting

confidence: 93%

Immunomodulatory vitamin D effects on regulatory T-cells and cytokines in anin vitrostudy on patients with systemic lupus erythematosus

Ghoryani

Sahebari

Mahmoudi

et al. 2015

Food and Agricultural Immunology

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting various organs. Decreased numbers of regulatory T-cells (Treg cells; CD4 + CD25 high Foxp3 + ) are associated with the pathogenesis of SLE. A vitamin D deficiency was observed in many lupus patients. In the present study, peripheral blood mononuclear cells were isolated and cultured in the presence or absence of vitamin D, and total Tregs percentage was analyzed by flow cytometry. In addition, the level of expressions of Foxp3, TGFβ, and IL6 genes were analyzed by real-time-PCR. The results indicated that vitamin D treatment increased the percentage of Treg cells, and the expression of Foxp3 and TGFβ, and decreased the expression of IL6 in SLE patients. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 93%

Immunomodulatory vitamin D effects on regulatory T-cells and cytokines in anin vitrostudy on patients with systemic lupus erythematosus

Ghoryani

Sahebari

Mahmoudi

et al. 2015

Food and Agricultural Immunology

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“…Vitamin D supplementation (2000, 4000 or 50000 IU weekly for 6 months) in patients with SLE showed positive immunological effects by decreasing IL-17A-producing T cells and increasing FOXP3 expression, confirming the relationship between vitamin D status and immunological balance ( 131 ) . Furthermore, vitamin D consumption attenuated the disease progression and increased the number of regulatory T cells in mouse models ( 132 , 133 ) . In patients with SLE, in vitro treatment with vitamin D (50 n m ) has regulatory effects on apoptosis and cell cycle progression and modifies the expression levels of apoptotic genes ( 134 ) ; in addition, vitamin D intake (400 000 IU followed by 20 000 IU weekly for 12 weeks) can positively modulate endothelial function in patients with stable SLE, reducing cardiovascular risk ( 135 ) .…”

Section: Micronutrientsmentioning

confidence: 99%

An update on diet and nutritional factors in systemic lupus erythematosus management

2017

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Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease characterised by multiple organ involvement and a large number of complications. SLE management remains complicated owing to the biological heterogeneity between patients and the lack of safe and specific targeted therapies. There is evidence that dietary factors can contribute to the geoepidemiology of autoimmune diseases such as SLE. Thus, diet therapy could be a promising approach in SLE owing to both its potential prophylactic effects, without the side effects of classical pharmacology, and its contribution to reducing co-morbidities and improving quality of life in patients with SLE. However, the question arises as to whether nutrients could ameliorate or exacerbate SLE and how they could modulate inflammation and immune function at a molecular level. The present review summarises preclinical and clinical experiences to provide the reader with an update of the positive and negative aspects of macro- and micronutrients and other nutritional factors, including dietary phenols, on SLE, focusing on the mechanisms of action involved.

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“…Neutrophils express VDRs too [78]; studies in SLE showed that, when bound by their ligand 1,25(OH)2D3, the activated VDR mediates an overall improvement of the endothelial damage secondary to the decreased generation of Neutrophils-Extracellular-Traps (NET) [79]. Some of the vitamin D effects observed in vitro were replicated in animal models of lupus, for instance, its ability to favour Treg differentiation and Foxp3 expression [80], to reduce IL-17/23, IFN-gamma and IL-6, and to decrease the titre of anti-dsDNA antibodies [80,81]. A potential therapeutic role for vitamin D in improving clinical manifestations of lupus was hypothesised based on the decreased severity of the disease observed in MRL/1 mice treated with 1,25(OH)2D3 [82].…”

Section: Role Of Vitamin D In the Immune System Regulationmentioning

confidence: 99%

To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus

Nerviani¹,

Mauro²,

Gilio³

et al. 2018

TORJ

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Background: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal activation of the immune system, chronic inflammation and organ damage. Lupus patients are more prone to be vitamin D deficient. However, current evidence is not conclusive with regards to the role played by vitamin D in SLE development, progression, and clinical manifestations. Objective: Here, we will summarise the current knowledge about vitamin D deficiency prevalence, risk factors, molecular effects, and potential pathogenic role in SLE. We will focus on the link between vitamin D deficiency and lupus clinical manifestations, and on the clinical trials assessing the effects of vitamin D supplementation in SLE. Method: A detailed literature search was performed exploiting the available databases, using “vitamin D and lupus/SLE” as keywords. The relevant interventional trials published over the last decade have been considered and the results are reported here. Conclusion: Several immune cells express vitamin D receptors. Thus, an immunomodulatory role for vitamin D in lupus is plausible. Numerous observational studies have investigated the relationship between vitamin D levels and clinical/serological manifestations of SLE with contrasting results. Negative correlations between vitamin D levels and disease activity, fatigue, renal and cardiovascular disease, and anti-dsDNA titres have been described but not conclusively accepted. In experimental models of lupus, vitamin D supplementation can improve the disease. Interventional trials have assessed the potential therapeutic value of vitamin D in SLE, but further larger studies are needed.

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Assessment of 1,25-dihydroxyvitamin D3 effects on Treg cells in a mouse model of systemic lupus erythematosus

Cited by 29 publications

References 34 publications

Immunomodulatory vitamin D effects on regulatory T-cells and cytokines in anin vitrostudy on patients with systemic lupus erythematosus

Immunomodulatory vitamin D effects on regulatory T-cells and cytokines in anin vitrostudy on patients with systemic lupus erythematosus

An update on diet and nutritional factors in systemic lupus erythematosus management

To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus

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