Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness

Arslan, Nur; Makay, Balahan; Hızlı, Şamil; Koçyi̇ği̇t, Ali; Demircioğlu, Fatih; Tuncel, Asuman; Çakmakçı, Handan

doi:10.1111/jpc.12301

Cited by 14 publications

(11 citation statements)

References 43 publications

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“…So, the level of MPV was low as atherosclerosis progressed in diabetes. Several studies showed that there is a strong positive correlation between MPV and FPG as well as HbA1c levels [9,[18][19][20], but it was in contrast to our research; we demonstrated that there was no association between MPVand HBA1c as well as FPG, but MPV was significantly associated with IMT, just like the conclusion of Arslan N et al [23]. IMT increases in the presence of diabetic macroangiopathy, which is thought to be a relatively easy, non-invasive technique to identify atherosclerosis.…”

Section: Discussioncontrasting

confidence: 85%

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

Wan

Zhang

et al. 2015

Int J Diabetes Dev Ctries

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Section: Discussioncontrasting

confidence: 85%

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

Wan

Zhang

et al. 2015

Int J Diabetes Dev Ctries

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“…These mediators can contribute to inflammation and atherogenesis and may explain the association between MPV and atherosclerosis. It has been previously shown that larger platelets are associated with severity of CAD [31], PAD [32][33], and carotid atherosclerosis [34][35]. Possible mechanism for correlation of larger platelets with ischemic stroke as shown in our study may be the augmented rate of atherosclerosis unlike atrial fibrillation or other prothrombotic conditions.…”

Section: Discussioncontrasting

confidence: 39%

Mean platelet volume is related with ischemic stroke in patients with sinus rhythm

Özkan

Arık

Gözükara

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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Stroke is the leading cause of disability worldwide. It is known that atrial fibrillation and left atrial enlargement contribute ischemic stroke, and mean platelet volume (MPV) increases in patients with ischemic stroke and atrial fibrillation. We aimed to determine whether higher MPV is associated with ischemic stroke in patients with sinus rhythm. We evaluated 74 patients in sinus rhythm and with ischemic stroke (Group 1) and 90 age-matched and sex-matched healthy individuals as control group (Group 2). After physical and echocardiographic examination, 24-48 h Holter monitoring and complete blood counts were studied. There were no statistically significant differences in age, sex rates, and comorbidities between groups. Left atrial diameter was higher in Group 1 than Group 2 (P = 0.001), but both were in normal range. MPV was significantly higher in Group 1 (P < 0.001) and was an independent determinant [odds ratio (OR): 1.840; P < 0.001; 95% confidence interval (CI) 1.330-2.545] of ischemic stroke with left atrial (OR: 1.138; P = 0.006; 95% CI 1.037-1.248). In conclusion, higher MPV is associated with acute ischemic stroke in patients with sinus rhythm and without heart failure or left atrial enlargement. MPV and left atrial diameter are independent predictors of ischemic stroke in this patient population.

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“…It has been demonstrated there is no relationship between MPV, platelet aggregation, carotid IMT, and the extent of coronary artery disease (23). However, a positive correlation between MPV and carotid IMT in obese adolescents was shown recently (24). Also, our study population consisted of patients who had non-atherosclerotic heart disease, and we found a positive correlation between thoracic aorta IMT and MPV.…”

Section: Discussionmentioning

confidence: 91%

Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease

Kalkan

Gür²,

Baykan³

et al. 2015

Anatol J Cardiol

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Objective:Mean platelet volume (MPV) plays a pivotal role in the pathophysiology of atherosclerotic disease. Thoracic aortic intima-media thickness (IMT) was reported as an earlier marker of preclinical atherosclerosis than carotid IMT. However, the relationship between MPV and aortic IMT was not investigated. We aimed to assess the relationship between thoracic aortic IMT and MPV in patients undergoing transesophageal echocardiography (TEE) examination for different indications.Methods:We studied 190 patients (mean age 37.0±12.5 years) who underwent TEE for different indications. The patients who have known atherosclerotic disease were excluded from study. The patients were divided into 2 groups according to the median thoracic aortic IMT values (IMTlow group <13 mm and IMThigh group ≤13 mm). Platelet count and MPV were analyzed with an automated hematology analyzer. A multiple stepwise linear regression analysis was performed to identify the independent associations of thoracic aortic IMT.Results:The highest MPV values were observed in the IMThigh group compared with the IMTlow group (9.5±10 fL vs. 10.9±1.2 fL, p<0.001). Also, the IMThigh group had higher age, hs-CRP and uric acid levels (p<0.05 for all). Multiple linear regression analysis showed that aortic IMT was independently related with age (β=0.340, p<0.001), uric acid (β=0.111, p=0.041), hs-CRP (β=0.200, p<0.001), and MPV (β=0.482, p<0.001).Conclusion:MPV is independently related to the extent of subclinical thoracic aortic atherosclerosis. Increases in MPV may be a crucial biochemical marker for initial atherosclerosis.

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Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness

Abstract: MPV is significantly correlated with CCA thickness in obese adolescents.

Cited by 14 publications

References 43 publications

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

Mean platelet volume is related with ischemic stroke in patients with sinus rhythm

Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease

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