Assessment of changes in lactate concentration with intravascular microdialysis during high-risk cardiac surgery using the trend interchangeability method

Gouëzel, Corentin; Lorne, Emmanuel; Bonnet, Vincent; Fradin, Sabine; Saplacan, Vladimir; Gérard, Jean-Louis; Hanouz, Jean‐Luc; Fischer, Marc-Olivier

doi:10.1093/bja/aex338

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Intravenous microdialysis has previously been used to evaluate metabolites (e.g., lactate, glucose, pyruvate, and creatinine) [ 8 , 16 , 17 , 18 , 19 , 20 ], antibiotics (e.g., glycopeptides, aminoglycosides, and cephalosporins) [ 5 , 6 , 21 ], and antifungals (e.g., fluconazole) [ 22 ]. Studies investigating metabolites have primarily reported lower metabolite concentrations obtained by intravenous microdialysis in comparison to standard plasma sampling [ 16 , 17 , 18 , 19 , 20 ], although one study found a good correlation [ 21 ]. For flomoxef and fluconazole, comparable concentrations were found with the two sampling methods [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Intravenous Microdialysis and Standard Plasma Sampling for Monitoring of Vancomycin and Meropenem Plasma Concentrations—An Experimental Porcine Study

et al. 2023

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Microdialysis is a catheter-based method suitable for dynamic sampling of unbound antibiotic concentrations. Intravenous antibiotic concentration sampling by microdialysis has several advantages and may be a superior alternative to standard plasma sampling. We aimed to compare concentrations obtained by continuous intravenous microdialysis sampling and by standard plasma sampling of both vancomycin and meropenem in a porcine model. Eight female pigs received 1 g of both vancomycin and meropenem, simultaneously over 100 and 10 min, respectively. Prior to drug infusion, an intravenous microdialysis catheter was placed in the subclavian vein. Microdialysates were collected for 8 h. From a central venous catheter, plasma samples were collected in the middle of every dialysate sampling interval. A higher area under the concentration/time curve and peak drug concentration were found in standard plasma samples compared to intravenous microdialysis samples, for both vancomycin and meropenem. Both vancomycin and meropenem concentrations obtained with intravenous microdialysis were generally lower than from standard plasma sampling. The differences in key pharmacokinetic parameters between the two sampling techniques underline the importance of further investigations to find the most suitable and reliable method for continuous intravenous antibiotic concentration sampling.

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