Assessment of Coronary Arterial Plaque by Optical Coherence Tomography

Kume, Teruyoshi; Akasaka, Takashi; Kawamoto, Takahiro; Watanabe, Nozomi; Toyota, Eiji; Neishi, Yoji; Sukmawan, Renan; Sadahira, Yoshito; Yoshida, Kiyoshi

doi:10.1016/j.amjcard.2005.11.035

Cited by 351 publications

(159 citation statements)

References 28 publications

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“…1 -3 Optical coherence tomography, which can provide a detailed evaluation of the plaque nature, has also been developed. 4,5 Although physiological assessment, including stress electrocardiogram, echocardiography, and single-photon emission computed tomography (SPECT) cannot be performed simultaneously with anatomical assessment, the assessment of physiological indicators by fractional myocardial flow reserve (FFR) using a pressure wire in recent years has allowed simultaneous evaluation with CAG. An FFR value <0.80 identifies ischemia-causing coronary stenoses with an accuracy of >90%.…”

Section: Introductionmentioning

confidence: 99%

Impact of Lesion Length on Functional Significance in Intermediate Coronary Lesions

Iguchi

Hasegawa

Nishimura

et al. 2012

Clinical Cardiology

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Background: Myocardial fractional flow reserve (FFR) is useful in the evaluation of coronary lesion ischemia. However, the impact of lesion length on FFR has not been adequately assessed. Hypothesis: We hypothesized that lesion length would influence functional significance in intermediate coronary lesions. Methods: FFR measurements were assessed in 136 patients (163 lesions) with stable angina who had >40% stenotic coronary lesion by quantitative coronary angiography (QCA). One hundred sixty-three lesions were classified as intermediate (40%-70% stenosis; n=107; group I) or significant (≥70%; n=56; group S) by QCA. We assessed the relationships between lesion length, coronary stenosis, and FFR in these 163 lesions. Results: Regression analysis revealed an inverse correlation between the percentage of diameter stenosis (%DS) and FFR in group S (r = −0.83, P < 0.0001). In group I, no significant correlation was found between %DS and FFR (r = −0.06, P = 0.55), whereas lesion length was significantly inversely correlated with FFR (r = −0.79, P < 0.0001). Receiver operating characteristic curve analysis demonstrated that the best cutoff value for predicting an FFR value <0.80 was a lesion length >16.1 mm in group I (sensitivity, 86%; specificity, 94%). Conclusions: These study findings suggest that lesion length has a physiologically significant impact on intermediate-grade coronary lesions.

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Section: Introductionmentioning

confidence: 99%

Impact of Lesion Length on Functional Significance in Intermediate Coronary Lesions

Iguchi

Hasegawa

Nishimura

et al. 2012

Clinical Cardiology

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“…Importantly, a histology-controlled OCT study showed >90% sensitivity and specificity for detecting lipid-rich plaque in comparisons with pathological specimens. [9,10]. Moreover, OCT can recognize vulnerable plaques, such as plaque rupture, erosion, intracoronary thrombus, TCFA.…”

Section: Clinical Applications Of Oct Imagingmentioning

confidence: 99%

Clinical and Research Applications of Optical Coherence Tomography Imaging in Coronary Artery Disease

Hasegawa¹,

Shimada²

2013

What Should We Know About Prevented, Diagnostic, and Interventional Therapy in Coronary Artery Disease

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“…OCT can accurately assess plaque characteristics such as calcifications, fibrous and lipid-rich plaque components, as well as the presence of dense macrophage infiltration, neovascularization and mural/luminal thrombi (15)(16)(17)(18)(19). Unfortunately, because of its limited tissue penetration, OCT is not suitable to properly visualise the external elastic membrane (EEM) in heavily diseased segments so that IVUS remains the gold standard to study vessel remodelling (19,20).…”

Section: Review Articlementioning

confidence: 99%

Optical coherence tomography guidance during bioresorbable vascular scaffold implantation

Secco¹,

Verdoia²,

Pistis³

et al. 2017

J. Thorac. Dis.

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In the last decades angiography has been the keystone to assess coronary anatomy, leading to a rapid development of percutaneous revascularisation techniques. Despite the widespread dissemination and high reproducibility, angiography provides a limited analysis of arterial lumen profile without the possibility to disclose vessel wall characteristics and composition of coronary plaques. Intracoronary imaging techniques have been developed to overcome these limitations. Intravascular ultrasound (IVUS) was the first technique introduced in interventional cardiology in the early 90ies (1), followed more than a decade after by optical coherence tomography (OCT). OCT is a light-based technology that similar to IVUS provides information about intravascular anatomy that far exceeds the level of detail obtained from conventional angiography (2). The use of near-infrared light rather than ultrasound reflectance allows OCT to have greater resolution at the price of lower penetration power. Moreover, near-infrared light is scattered by red blood cells, and therefore OCT use for guidance of intervention is limited by the need of prolonged crystalloid infusion during imaging (3,4). In so forth, the penetrance of OCT in daily clinical practice was limited and the technology was mainly employed as a research tool to investigate plaque morphology and strut endothelialisation (5). The frequency domain OCT system (FD-OCT) has the advantage of a more rapid image acquisition due to the fast-scanning laser systems minimising the contrast use and increasing imaging speed while delivering an improved image quality than with the earlier time domain systems (TD-OCT) (6). This The high-resolution power together with the lack of shadowing observed beyond polymer struts makes optical coherence tomography (OCT) the optimal imaging technique to guide BRS implantation and identifies eventually scaffolds failures.

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Assessment of Coronary Arterial Plaque by Optical Coherence Tomography

Cited by 351 publications

References 28 publications

Impact of Lesion Length on Functional Significance in Intermediate Coronary Lesions

Impact of Lesion Length on Functional Significance in Intermediate Coronary Lesions

Clinical and Research Applications of Optical Coherence Tomography Imaging in Coronary Artery Disease

Optical coherence tomography guidance during bioresorbable vascular scaffold implantation

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