Assessment of coronary stenoses by Doppler wires: a validation study using in vitro modeling and computer simulations

Porenta, Gerold; Schima, Heinrich; Pentaris, A.; Tsangaris, S.; Moertl, Deddo; Probst, Peter; Maurer, Gerald; Baumgartner, Helmut

doi:10.1016/s0301-5629(99)00033-2

Cited by 20 publications

(10 citation statements)

References 21 publications

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“…Fine wires that have diameters ranging from tens of microns to hundreds of microns are used extensively in medical devices such as guidewires,1 catheters,2 pacemakers,3 stents,4 and staples 5. Fine wires are made from a variety of metals and alloys including MP35N, tantalum, titanium, and stainless steel.…”

Section: Introductionmentioning

confidence: 99%

Measuring mechanical properties of fine‐wire cross‐sections used in medical devices

Polycarpou

Johnson

2004

J Biomed Mater Res

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In this study, it was demonstrated that the nanoindentation technique can be used to measure the elastic modulus and hardness of fine-wire cross-sections with diameters ranging from 100-200 microm. Using miniature optics and a specially developed micrometer positioning system, measurements were successfully performed on the wire cross-sections with an accuracy of 1 microm. Homogeneous wire cross-sections, such as MP35N (high-strength nickel-cobalt alloy), composite wires such as MP35N with a silver core (MP35N/Ag-core), and platinum-clad tantalum (Pt-clad Ta) were studied. From the nanoindentation measurements, the elastic modulus and hardness at different positions and depths were calculated. It was found that both elastic modulus and hardness reached a constant value below the hardened surface, which resulted from mechanical polishing. Material properties obtained from the measurements were compared with the literature values of bulk materials as well as available results on fine wires. The data from the wire cross-sections, especially the uniform material samples, showed that both the elastic modulus and hardness were significantly lower near the outer 10-15 microm of the wire as compared to the rest of the wire, which is due to surface weakening during manufacturing. In addition, both modulus and hardness showed a small but consistent "sawtooth" variation across the diameter of the wires, excluding the outer 10-15 microm, that is postulated to be induced by the distribution of residual stress.

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Section: Introductionmentioning

confidence: 99%

Measuring mechanical properties of fine‐wire cross‐sections used in medical devices

Polycarpou

Johnson

2004

J Biomed Mater Res

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“…Distal to the throat, flow separation and reattachment occurs along the lesion wall, indicated by negative axial velocities and t w o0 near the lesion wall. This flow separation in the distal vessel could play a significant role in underestimation of true flow reserve in moderate stenoses (Porenta et al, 1999).…”

Section: Velocity Profiles Along the Lesionmentioning

confidence: 99%

Guidewire flow obstruction effect on pressure drop-flow relationship in moderate coronary artery stenosis

Roy

Back

Banerjee

2006

Journal of Biomechanics

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“…Second, the measurement is very sensitive to the location of the wire relative to the stenosis (proximal/distal) and to the orientation of the wire inside the artery [21]. Therefore, the reliability of such measurements is only moderate [20] with a limited agreement of two consecutive measurements.…”

Section: Limitationsmentioning

confidence: 99%

A new angiographic method to assess coronary flow reserve—Validation in humans

Rittger

Kuper²,

Breithardt

et al. 2009

Cathet Cardio Intervent

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Assessment of coronary stenoses by Doppler wires: a validation study using in vitro modeling and computer simulations

Cited by 20 publications

References 21 publications

Measuring mechanical properties of fine‐wire cross‐sections used in medical devices

Measuring mechanical properties of fine‐wire cross‐sections used in medical devices

Guidewire flow obstruction effect on pressure drop-flow relationship in moderate coronary artery stenosis

A new angiographic method to assess coronary flow reserve—Validation in humans

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