Given the key roles of the Indo-China Peninsula (ICP) in weather and climate systems, hydrometeorology, and ecology, the annual and monthly changes in the Food and Agriculture Organization-56 Penman-Monteith reference evapotranspiration (ET 0 ), which was calculated based on the Climatic Research Unit datasets, were investigated in ICP during 1961-2017. The annual ICP ET 0 significantly (p < .05) increased, with different increasing tendencies in most months. In particular, larger and more significant (p < .05) ET 0 values were found during October-December. The annual and monthly ET 0 changes showed evident spatial differences, characterized by increases in more than 50% of the ICP area except for decreases in around 70% of that area during March-May. A sensitivity experiment-based separation method was utilized to evaluate the contribution of each influential factor, and the corresponding determinants were identified by comparing the contributions. Results showed that the annual ICP ET 0 increase was attributed to the increased vapour pressure deficit (Vpd). However, the annual determinants varied spatially, with net solar radiation (Rn) in the southern region of ICP, wind speed (Wnd) in the northeast, and Vpd in the remaining regions. The monthly ICP determinant was Wnd in January, March-May and December, and Vpd for the remaining months. Despite different spatial patterns of monthly dominants, Vpd and Wnd were the determinants with the most extensive distributions over ICP (>75% of ICP in total). The results of this study can significantly fulfil the research gap regarding the ICP ET 0 changes and the underlying mechanisms.