Assessment of fasting blood glucose, serum electrolyte, albumin, creatinine, urea and lipid profile among hypertensive patients and non-hypertensive participants at wolaita sodo university teaching and referral hospital, SNNPR, Ethiopia

Abstract

Background: Hypertension is a silent killer that requires long term management to avoid complications. It is one of major public health problem in developing counties like Ethiopia. Hypertension increases the risk of morbidity and mortality and has negative consequences on the cognitive and physical fitness of productivity in adults. Objective: To assess fasting blood glucose, serum electrolyte, albumin, creatinine, urea, and lipid profile among hypertensive patients and non-hypertensive participants at wolaita sodo teaching and referral hospital. Methods: A comparative cross-sectional study was conducted from December 2019 to February 2020. On the study a total of 156 study participants (78 cases and 78 controls) were involved. Each study participant, after signing informed consent, interviewed about the socio-demographic and anthropometric characteristic features. Then 5ml of the blood sample was collected from each 78 patients with hypertension and each 78 samples from apparently healthy subjects from WSUTRH during the period. Fasting blood glucose, serum electrolyte, albumin, creatinine, urea, and lipid profile level were measured in each group. The Data were analyzed by using Epi data version 3.1 and SPSS version 21.0 software (IBM Corporation, USA) and results were summarized using means and percentages and presented by using figures and tables. P-value < 0.05 was considered to be significant at 95% confidence level. Any abnormal laboratory results of study subjects dispatched and communicated with physicians for better management. Results: The mean age of hypertensives and control study groups were 50 ± 10.0 and 51 ± 11.3 years respectively. The body mass index of hypertensives and control study groups were 53.4% and 34.2% overweighed respectively. The mean ± SD of fasting blood glucose, total cholesterol, LDL-C, TG, RFT were significantly increases while serum sodium, calcium, albumin, and HDL- Cholesterol significantly decreased in hypertensives when compared with non-hypertensives and serum potassium was no statistical significance among case and control groups. Conclusion: In present study, we observed that the hypertensive group was at risk for developing biochemical alteration in creatinine, urea, fasting blood glucose, lipid profile, electrolytes, and albumin test parameters with an increased period of time. Recommendation: Regular measurements of biochemical parameters strongly needed for hypertensive patients.

Interactions between caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study

“…All blood samples were collected after having an 8–12 h fasting state at the Nutrition and Genomics Laboratory of TUMS. Moreover, fasting blood sugar (FBS), TG, total cholesterol level, low-density lipoprotein (LDL), and HDL were measured according to standard protocols [ 17 ]. All of which were measured at the Bionanotechnology laboratory, Tehran University of Medical Science.…”

The effect of angiotensin converting enzyme gene insertion/deletion polymorphism on anthropometric and biochemical parameters among hypertension patients: A case-control study from Northwest Ethiopia

“…In addition, hypertension may induce microvascular dysfunction through an increase in the production of superoxide anions and hydrogen peroxide (levels of reactive oxygen species) and a decrease in nitric oxide synthesis [ 42 , 43 ] which may result in insulin resistance and hyperglycemia. Previous studies also documented that biomarkers of endothelial dysfunction were found to be independent predictors of hyperglycemia [ 38 ]. This implies hypertension would contribute to the pathophysiology of type II diabetes development.…”

“…Conversely, higher blood pressure among hypertensive cases would result in increased renal tubular reabsorption and increased arterial pressure. This would also lead to higher values of glomerular capillary wall stress, activation of neuro-humoral systems, and increased serum lipid level among cases [ 38 ]. This implies that high TG, high LDL-c, and low HDL-c levels are associated with increased blood pressure and atherosclerosis [ 16 ].…”

Interaction of Caveolin-1 gene polymorphism with processed meats on anthropometric measurements and body composition in obese and overweight women: A cross-sectional study

“…A validated 147-items semi-quantitative food frequency questionnaire (FFQ) with high validity and reliability was used (32) by an expert to evaluate the dietary intake of the participants. Aimed at the calculation of macro-and micronutrient content, grams of foods were entered into NUTRITIONIST IV software (version 7.0; N-Squared Computing, Salem, OR) (33).…”

“…Blood samples were prepared after 10-12 hours night fasting at the nutrition and Biochemistry laboratory of the school of nutritional Sciences and Dietetics, TUMS. Additionally, fasting blood sugar (FBS), liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), Highsensitivity C-reactive protein (hs-CRP), Monocyte chemoattractant protein-1 (MCP-1), interleukin 1 beta (IL-1β) and transforming growth factor beta1(TGF-β1), serum lipids and lipoproteins ,triglycerides (TG), total cholesterol level, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured according to standard protocols (32) Genotyping DNA was extracted for genotyping the Cav-1 polymorphisms from total blood via a Mini Columns kit (Type G; Genall; Ex gene). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was hired to investigate Cav-1 polymorphisms (rs3807992) in gene fragments (major allele G and minor allele A).…”