Assessment of gelsolin level in women with heart disease after menopause

Al-Kraity, Wijdan Rajh Hamza; Al-Dujaili, Arshad Noori

doi:10.5958/0974-360x.2017.00292.x

Cited by 15 publications

(11 citation statements)

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“…The current study in figure (1) indicates a significant decrease in Neudesin level in PCOs women in compare with control group. The present results agree with recent studies has been postulated a several mechanisms for this decrement with Neudesin, one of these explanation may depended on association or binding of a group of protein like hemebinding domain related to cytochrome p450 monooxygenase system called progesterone receptor membrane protein component 1(PGRMC1) has a diverse effect on cholesterol/ steroid biosynthesis by interact with cytochrome 450 and one of these protein is a Neudesin, therefor low level of neudesin with low level of progesterone contribute to suppress a negative feed on pituitary gland effect on GnRh and inhibition of GnRh but release of LH [10,17]. Another mechanism for neudesin low level may lead to immortalized GnRh neurons (GT1-7cells) and calcium level in GnRh has been inhibited leading to FSH level decrement and LH release [18].…”

Section: Discussionmentioning

confidence: 99%

Estimation the level of Neudesin in Polycystic ovarian syndrome patients

Salih,

Al-Dujaili

2024

BIO Web Conf.

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic ovulation dysfunction and overabundance of androgens; it affects women at reproductive age. The aim of the current study were to detect the analytic estimation of serum Gremlin as well as studying the relation between this biomarker and Body Mass Index (BMI), age, waist /hip ratio and type of infertility in Polycystic ovarian syndrome patients. Methods: The current study was conducted on 90 women (60 patients with polycystic ovary syndrome and 30 healthy control) ranging in their ages from 15-39 years in period from March to June, 2023. Blood samples were collected from women and serum samples prepare to estimate the serum levels of Gremlin. Results: The results indicated that there was a significant increase (P-Value< 0.05) in Gremlin levels in patients group when compare with control group. Also, after dividing the group of patients into three groups according to ages, we notice a significant increase (P-Value< 0.05) in Gremlin levels in age less than 20 years when compare with age 20-29 years and age 30-39 years, and a significant increase (P-Value< 0.05) in Gremlin levels in age 20-29 years when compare with age 30-39 years. On the other hand, when dividing the group of patients according to body mass index we notice a significant decrease (P-Value< 0.05) in Gremlin level in overweight group when compare with obese group and significant decrease (P-Value< 0.05) in Gremlin level in moderate W/H ratio group when compare with high W/H ratio group and no significant difference found between primary and secondary infertility. Conclusion: The current study concluded that a Gremlin is a prognostic marker in early detection of polycystic ovarian syndrome.

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Section: Discussionmentioning

confidence: 99%

Estimation the level of Neudesin in Polycystic ovarian syndrome patients

Salih,

Al-Dujaili

2024

BIO Web Conf.

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“…The current study agrees with recent research that found no difference in fibromodulin, biglygcan, lumican and versican between the two sex because type I and type III collagen were present as some between males and females and collagenous tissue changes were similar as a properties for mechanical function (25) . Former study on fibromodulin in osteoarthritis has proved that fibromodulin showed high levels in advanced stage than early because it is associated with higher chondrocyte proliferation and stimulating apoptosis (26,27) . No previous studies about the level in all types of development of abnormal dysplasia of hip with clubfoot complications and severity combined with accumulation of collagen fiber & abnormality of ECM.…”

Section: Discussionmentioning

confidence: 99%

Fibromodulin Level in Association with Clubfoot Disease and Congenital Dislocation of Hip in Children Patients in Najaf Province

Mohammed¹,

Al-Dujaili²

2022

The Egyptian Journal of Hospital Medicine

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Background:The main characterizations of foot deformity, which is called congenital talipes equinovarus, in severity and variation degree depend on complications and congenital malformations. They are classified into four main components such as midfoot cavus, forefoot adducts, heel/hind foot various and hind foot equines.Objective: This study aimed to estimate some of biochemical markers such as asporin, fibromodulin and tenascin-C in club foot child disease to determine pathological causes of severe deformity of bone, for monitoring complications of bone mineralization and calcification and for early treatment using drugs of choice. Patients and Methods: 60 Clubfoot patients with dislocation dysplasia of Hip (DDH) disease were included in this study. The samples were collected from Clubfoot Unit and private centers in Holy Najaf, Iraq during the period from December 2020 to February 2021. The patients groups were divided into subgroups according to age, gender, idiopathic, syndrome, Parina score, body mass index (BMI) and clubfoot. The control group included 30 apparent healthy participants and the age was nearly matched with patients' groups. Results:The level of tenascin-C was increased significantly in clubfoot patients than in control group. Also, tenascin-C level was highly increased in advanced ages (3-5) years in comparison with other ages and in males than in females. Also, high score (6-7) was significantly increased than other scores. The present results showed that club foot with dislocation dysplasia of hip was highly significant compared to clubfoot only and dislocation dysplasia of hip only in all children patients. Moreover, clubfoot syndrome was higher than idiopathic syndrome significantly whereas no differences in tenascin-C level in all subgroups according to BMI (normal, overweight and obese) of children of clubfoot. Conclusion: Increased levels of tenascin-C is very important as a pathological marker in patients of clubfoot with dysplasia of Hip.

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“…According to these findings, MASP2 might be used as an earlier biomarker for CVD risk in PM women, contributing to protect against CVD development in this population. Interestingly, as described for MASP2, GELS (together with estradiol, E2) has also been reported as a marker for the detection and diagnosis of CVD after menopause [ 36 ]. GELS is an actin-binding protein involved in a variety of both physiological and pathological processes, such as apoptosis, signal transduction, transcriptional regulation, and modulation of the inflammatory and immune response.…”

Section: Discussionmentioning

confidence: 99%

Urinary Proteomics Reveals Promising Biomarkers in Menstrually Related and Post-Menopause Migraine

Bellei

Bergamini

Rustichelli

et al. 2021

JCM

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Migraine is an invalidating neuro-vascular disorder largely spread in the world population. Currently, its pathophysiology is not yet completely understood. The purpose of this study was to investigate the urinary proteome of women suffering from menstrually related migraine (MM) and post-menopause migraine (PM) in comparison with non-headache women as controls, to search potential biomarkers of these migraine sub-types. Urine samples were analyzed by mono-dimensional gel electrophoresis (SDS-PAGE) and two-dimensional gel electrophoresis (2DE) coupled to liquid chromatography-mass spectrometry (LC-MS/MS). Twenty-one urinary proteins were found significantly dysregulated in MM and PM (p < 0.05). The STRING Analysis database revealed interaction between 15 proteins, which were mainly involved in the immune and inflammatory response. Seven of the most considerable proteins were further quantified by western blot: protein S100A8 (S10A8), up-regulated in MM, uromodulin (UROM), alpha-1-microglobulin (AMBP), gelsolin (GELS), prostaglandin-H2 D-isomerase (PTGDS), over-expressed in PM, apolipoprotein A-I (APOA1), and transthyretin (TTHY), respectively down- and up-regulated in both migraineur groups vs controls. These candidate biomarkers might be involved in the neurophysiological network of MM and PM, thus helping to better understand the pathophysiology of these migraine forms. If validated in large-scale studies, this protein cluster could become a distinctive target for clinical applications in migraine diagnosis and treatment.

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Assessment of gelsolin level in women with heart disease after menopause

Cited by 15 publications

References 0 publications

Estimation the level of Neudesin in Polycystic ovarian syndrome patients

Estimation the level of Neudesin in Polycystic ovarian syndrome patients

Fibromodulin Level in Association with Clubfoot Disease and Congenital Dislocation of Hip in Children Patients in Najaf Province

Urinary Proteomics Reveals Promising Biomarkers in Menstrually Related and Post-Menopause Migraine

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