Assessment of In vivo antioxidant properties of Dacryodes edulis and Ficus exasperata as anti-malaria plants

Conrad, Omonhinmin A.; Uche, Agbara I

doi:10.1016/s2222-1808(13)60072-9

Cited by 19 publications

(8 citation statements)

References 19 publications

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“…plant leaves are used as traditional medicines for managing numerous diseases (Akinwumi & Sonibare, 2019). Notably, the folkloric medicinal use of FE as an antihypertensive agent was reported by Conrad and Uche (2013), Adewole et al. (2011), and Oboh et al.…”

Section: Introductionmentioning

confidence: 94%

Fig ( Ficus exasperata and Ficus asperifolia )‐Supplemented diet improves sexual function, endothelial nitric oxide synthase and suppresses tumour necrosis factor‐alpha genes in hypertensive rats

et al. 2021

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We measured the effect of varieties of Fig leaves, Ficus exasperata Vahl. (FE) and Ficus asperifolia Miq (FA), commonly found in Sub‐sahara Africa for managing hypertension on sexual performance in hypertensive rats, which is unknown. Hypertensive rats experienced erectogenic damage after exposure to 40 mg kg−1 bw−1, N(G)‐nitro‐l‐arginine‐methyl‐ester (L‐NAME). Experimental rats were grouped into eight groups (n = 6) namely: control rats, hypertensive rats, hypertensive treatment groups with atenolol (10 mg kg−1 day−1) and sildenafil (5.0 mg/kg), rats treated with FE‐ and FA‐formulated biscuits at proportions of 2.5 g and 5.0 g respectively. Furthermore, we measured the level of sexual performance (Intromission number, latency, Mounting number, and latency), hormonal levels, phosphodiesterase‐5 enzyme (PDE‐5) activity and genes expressed using real‐time quantitative polymerase chain reaction (RT‐qPCR) in hypertensive rats. The result deduced revealed that treated hypertensive rats showed significantly reduced follicle‐stimulating hormone, luteinising hormone levels, PDE‐5 enzyme activity, tumour necrosis factor‐alpha (TNF‐α) expression while having a marked increase in testosterone level, sexual performance and endothelial nitric oxide synthase (eNOS) expression. Therefore, this study revealed the comparative dietary enhancing effect of FE‐ and FA‐formulated biscuit on sexual behaviour activity, hormonal levels and the level of eNOS and TNF‐α genes expressed in hypertensive rats.

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Section: Introductionmentioning

confidence: 94%

Fig ( Ficus exasperata and Ficus asperifolia )‐Supplemented diet improves sexual function, endothelial nitric oxide synthase and suppresses tumour necrosis factor‐alpha genes in hypertensive rats

et al. 2021

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“…F. exasperata root paste alone and the bark crushed with the root of Croton roxburghii in coconut milk are applied externally to treat eczema [225]. Other studies reported antioxidant and antimalarial dose-dependant effects of Ficus exasperata extracts [226,227]. Similarly, Adebayo et al [228] revealed antimicrobial effects of the hydroalcoholic extracts of its leaves.…”

Section: Ethnomedical and Pharmacological Evidencementioning

confidence: 99%

Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof

Roger

Yougouda

Guidawa

et al. 2020

JMHE

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COVID-19 is a severe acute respiratory syndrome-related corona-virus SARS-CoV-2, that constitutes a pandemic threat to global public health. Unfortunately, there are no specific available therapies. This research work presents the ﬁndings of an investigation on traditional Cameroonian remedies of respiratory tract infections, malaria and viral infections, and also recipes that could serve as a baseline for the prevention, alleviate symptoms, treatment and perhaps may help for the anti-COVID-19 drugs discovery. Data on the medicinal plants were collected from traditional healers, Cameroonian medicinal plants books, the internet, and in addition to our personal experience as researchers and herbalists. Details of 85 plant species used to manage these three mentioned diseases in Cameroon and their pharmacological properties are recorded. Due to their ethnomedicinal uses and pharmacological activities, twenty-eight (28) plant species and 13 recipes are suggested for COVID-19 prevention, alleviate symptoms, treatment and baseline for anti-COVID-19 drug discovery. Amongst the proposed plants we have the following, Curcuma longa, Azadirachta indica, Zingiber officinale, Allium sativum and Ocimum gratissimum which were reported to possess certain inhibition properties against COVID-19 protease.

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“…Earlier studies on assessment of in vivo antioxidant properties of Dacryodes edulis, Ficus exasperata, Allamanda cathartica and Bixa orellanaas anti-malaria plants (Conrad and Uche, 2013; showed a dose-dependent effects of the plant extracts on the enzymes; catalase, glutathione and the thiobarbituric acid reactive substances (TBARS).…”

Section: Dose-dependent Anti-oxidant Activitymentioning

confidence: 99%

“…Malaria is a global disease, with an estimated 1-2 million persons affected every year (Saxena et al, 2003) and with high mortality rate in children and pregnant women, particularly in developing tropical countries like Nigeria, calls for increased attention. Traditional management of malaria in Nigeria and in most West African region involves the uses of a mixture of plants for anti-malarial formulations called "Agbo" among the locals (Conrad and Uche, 2013). Earlier, Sofowora (1994) identified Azadirachta indica, Alstonia boonei, Carica papaya and Mangifera indica has local plant resources for anti-malarial preparation in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical, Cytotoxicity and Antioxidant Activities of Five Anti-malaria Plants

Omonhinmin¹,

Dike²,

Rotimi³

2015

Research J. of Medicinal Plant

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The study investigated the phytochemical, cytotoxicity and antioxidant properties of Allamanda cathartica (AC), Bixa orellana (BO), Cymbopogon citratus (CC), Ficus exasperata (FE) and Momordica charantia (MC) used traditionally for the anti-malarial preparations "Agbo" in Nigeria. Phytochemical screening of the plants showed the presence of flavonoids, terpenoids, phenolics, cardiac glycosides and reducing sugars. Free radical scavenging activity of the plants with 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) recorded significant IC 50 values for the inhibition of DPPH by ethanolic leaves extracts of AC (0.46), BO (0.45), CC (1.35) and FE (0.86), respectively and Vit. E (control), recorded higher activity at 0.5 mg mLG 1 with an IC 50 of 0.25 μg mLG 1. BO leaf extracts recorded the most potent effect (0.45) at low concentration of 0.5 mg mLG 1. The free radical scavenging activities of these plants doubtlessly contribute to their use in indigenous malaria therapy and may qualify them for anti-malarial drug screening.

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Assessment of In vivo antioxidant properties of Dacryodes edulis and Ficus exasperata as anti-malaria plants

Cited by 19 publications

References 19 publications

Fig ( Ficus exasperata and Ficus asperifolia )‐Supplemented diet improves sexual function, endothelial nitric oxide synthase and suppresses tumour necrosis factor‐alpha genes in hypertensive rats

Fig ( Ficus exasperata and Ficus asperifolia )‐Supplemented diet improves sexual function, endothelial nitric oxide synthase and suppresses tumour necrosis factor‐alpha genes in hypertensive rats

Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof

Phytochemical, Cytotoxicity and Antioxidant Activities of Five Anti-malaria Plants

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