Assessment of Mechanical, Chemical, and Biological Properties of Ti-Nb-Zr Alloy for Medical Applications

Abstract

The purpose of this work is to obtain comprehensive reference data of the Ti-13Nb-13Zr alloy base material: its microstructure, mechanical, and physicochemical properties. In order to obtain extensive information on the tested materials, a number of examination methods were used, including SEM, XRD, and XPS to determine the phases occurring in the material, while mechanical properties were verified with static tensile, compression, and bending tests. Moreover, the alloy’s corrosion resistance in Ringer’s solution and the cytotoxicity were investigated using the MTT test. Studies have shown that this alloy has the structure α’, α, and β phases, indicating that parts of the β phase transformed to α’, which was confirmed by mechanical properties and the shape of fractures. Due to the good mechanical properties (E = 84.1 GPa), high corrosion resistance, as well as the lack of cytotoxicity on MC3T3 and NHDF cells, this alloy meets the requirements for medical implant materials. Ti-13Nb-13Zr alloy can be successfully used in implants, including bone tissue engineering products and dental applications.

Electrochemical and biological characterization of Ti–Nb–Zr–Si alloy for orthopedic applications

“…The same morphologies were reported for prolonged www.nature.com/scientificreports/ exposure to Ti-6Al-4V in inflammatory conditions 23 . The adsorption of Clions to oxygen vacancies in the presence of H 2 O 2 on the surface of the oxide/solution induces a flux of cation vacancies to the metal oxide interface and their annihilation 77,78 . As shown in Table ST5 for regions C, F, and I, more carbon is present correlating with expected BSA and CLH adsorption on Ti surfaces when immersed in the severe inflammatory condition media 29,79 .…”

Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

“…The desire to improve titanium alloys led to the development of several types of TiNb alloys without toxic and allergic alloying elements [ 49 , 50 , 51 ].…”

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

“…First, detailed studies should be performed on the influence of an AFAMBC on the ability of bacteria to form biofilm on surfaces of alloys currently used to fabricate parts of TJA, such as the stem of a total hip arthroplasty (for example, Ti-6Al-4V and Co-Cr-Mo[ 95 ], and those proposed for such use (for example, Ti-34Nb-2Ta-0.5O[ 96 ], Ti-12Nb-12Zr-12Sn[ 97 ], Ti-13Nb-13Zr[ 98 ], 40Ti-60Ta composite[ 99 ], Ti-39Nb-6Zr-0.45Al[ 100 ], and cold groove-rolled Ti-35Nb-3.75Sn[ 101 ]). Specifically, these studies should focus on determining the effectiveness of an AFAMBC vis a vis biofilms; that is, the extent to which an AFAMBC: (1) Inhibits microbial adhesion to the surface and colonization; (2) Interferes with the signal molecules that modulate biofilm formation (and associated increased antibiotic tolerance) (for example, quorum sensing inhibitors and/or quorum quenching agents[ 102 - 105 ]; and (3) Disaggregates the biofilm matrix[ 89 , 90 , 92 , 93 , 104 - 110 ].…”