Assessment of nipple discharge

Clinical utility of telomerase in cancer

“…In these cases, detectable telomerase activity might have indicated the existence of hidden cancer or the premalignant lesions of breast cancer. Nipple discharge (ductal lavage) may also become a useful and less invasive material for cancer cell detection (Leris et al, 2000). In thyroid tumors, for which FNA is a usual diagnostic tool, benign tumors such as follicular adenoma, Graves disease, and Hashimoto disease also show telomerase activity (Matthews et al, 2001).…”

Reply to Drs. Leris, Kouriefs, Williams, and Mokbel

“…

In response to the letter by Leris et al "Assessment of Nipple Discharge" [1] and in reference to our article [2], we are aware of the recent studies that demonstrate the importance of nipple discharge fluid through its complex biochemical and cellular composition-revealing alveolar gland aspects.Phillips et al [3] have demonstrated that samples of breast ductal fluid obtained by nipple aspiration make possible cytological examination by molecular and biological techniques. Moreover, methods concerning detection of enzymes such as telomerase [4,5] in malignancy are well known by us.

We have initiated a study to evaluate telomerase activity, metal proteins, and Ki-67 expression on nipple discharge fluids in patients with breast cancer.

…”

“…In response to the letter by Leris et al "Assessment of Nipple Discharge" [1] and in reference to our article [2], we are aware of the recent studies that demonstrate the importance of nipple discharge fluid through its complex biochemical and cellular composition-revealing alveolar gland aspects.…”

Διερεύνηση Της Σχέσης Της Ανευπλοειδίας Με Την Έκφραση Της Τελομεράσης Σε Εξεργασίες Οργάνων Της Ελάσσονος Πυελού Της Γυναίκας

“…Αντίθετα, η χρωμοσωμική αστάθεια ενεπλέκεται σε αρχικές φάσεις της καρκινογένεσης (Shin et al, 2001 (Hiyama et al, 2000). Το έκκριμα της θηλής του μαστού μπορεί επίσης να χρησιμοποιηθεί για ανίχνευση καρκινικών κυττάρων και τελομεράσης (Leris et al, 2000).…”