Assessment of Possible Link of Intestinal Microbiota and Type 2 Diabetes Mellitus

Simeon, George Gborienemi; Ibemologi, Arikekpar; Cameron, Dienize George

doi:10.4236/ajmb.2021.113006

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…Throughout life, the gut microbiota acts as a sensory hub, responding to both intrinsic and extrinsic stimuli affecting host physiology within and outside the gut [14]. Disruption of a delicate balance among the gut microbes has been linked to the development of metabolic diseases particularly type 2 diabetes mellitus [5], obesity [15], and cardiovascular disorders [16]. Most of the earlier studies reported differences between the gut microbiome of diabetics, prediabetics, and healthy nondiabetic individuals [6,17], and very few examined the gut microbiome of treatmentnaive T2DM individuals [18,19].…”

Section: Introductionmentioning

confidence: 99%

Association of Gut Microbiota with the Incidence of Metabolic Syndrome among Type 2 Diabetes Mellitus Patients

Porwal

2024

J Endo Metabol Res.

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Background: Alteration of the gut microflora leads to local intestinal inflammation which produces various primary and secondary metabolites that cause chronic inflammation, leading to metabolic syndrome. Objectives: To determine the gut microbiome about biochemical and inflammatory markers in type 2 diabetes patients and to assess the clinical outcomes of metabolic syndrome for gut microbiota composition. Methods: In this hospital-based observational study, 41 type 2 diabetes mellitus patients were included and underwent clinical examination. The gut microbiome diversity was detected from stool samples through DNA extraction followed by 16s RNA gene sequencing and bioinformatical analyses. Using blood samples, the immune response analysis was also done by identifying CD4+T cells through blood immune cells analysis. Results: After gene sequencing from stool samples, the gut microbiota species of rumonicoccus, fusobacterium, and blautia were identified among 9(42.9%), 9(42.9%), and 10(47.6%) patients only in the case group. However, fecalibacterium prasunitzii, bifidobacterium, akkermansia mucinphila and bacteriodes fragilis were 1(5%), 2(10%), 10(50%) patients only in the control group. In both groups, lactobacillus, and escherichia coli were seen among 3(15%) and 20(100%) patients in the control group, followed by 4(19%) and 20(95.2%) patients in the type 2 diabetes group. The incidence of metabolic syndrome was seen in 4(20%) patients in the control group and it was in 19(90.5%) patients in the case group where the prevalence of metabolic syndrome was significantly higher in the type 2 diabetes group than the control group (Fisher’s Exact Test, P=0.001). Conclusion: Among the studied population, the gut microbiota was found to be significantly different in the diabetics when compared to non-diabetics and helped to identify the bacteria that were important in the development of diabetes. The elevation of inflammatory markers further showed the possible role of gut microbiota in creating a state of chronic inflammation in these patients, ultimately leading to insulin resistance and the development of type 2 diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Association of Gut Microbiota with the Incidence of Metabolic Syndrome among Type 2 Diabetes Mellitus Patients

Porwal

2024

J Endo Metabol Res.

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“…Furthermore, alterations in the gut-junction protein, endocannabinoid system, and intestinal alkaline phosphatase are caused by changes in microbiota-dependent bacteria. Some probiotics have been shown to reduce the onset of diabetes by acting as interleukin (IL), IFN, or even influencing anti-inflammatory IL-10 production, according to research [9]. Other research has found that high fructose-fed rats have lower levels of serum glucose, insulin, leptin, c-peptide, glycated hemoglobin, GLP, inflammatory IL-6, and TNF in adipose tissue, and PPAR-and Glut4 gene expression [10].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Relationship between Bowel Microbiota and Impaired Glucose Tolerance

Attia

Elmetwalli

Eldiasty

2022

JPRI

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Background and Aim: Because of the large number of genes found in the gut microbiome, it has recently been determined that numerous human microorganisms have significant implications for human health. Aim: The significance of gut bacteria in the development of T2DM was investigated in this study. Materials and Methods: Microbial species were extracted from fecal materials; they were identified and quantified using genomic spectrophotometric equipment, and certain biochemical parameters for Diabetes were quantified. Result: We observed a concentration of firmicutes, Bacteroides, and proteobacteria, with the Escherichia coli population predominating. Biochemical parameters reveal a several-fold raised value for some biomarkers in T2DM. In a paired sample test results gave significant differences for all tested pairs. Conclusion: Microbiomes can affect the gut environment and trigger alterations that embolden the development of T2DM, according to study findings.

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Assessment of Possible Link of Intestinal Microbiota and Type 2 Diabetes Mellitus

Cited by 2 publications

References 31 publications

Association of Gut Microbiota with the Incidence of Metabolic Syndrome among Type 2 Diabetes Mellitus Patients

Association of Gut Microbiota with the Incidence of Metabolic Syndrome among Type 2 Diabetes Mellitus Patients

Exploring the Relationship between Bowel Microbiota and Impaired Glucose Tolerance

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