Assessment of pragmatic impairment in right hemisphere damage

Parola, Alberto; Gabbatore, Ilaria; Bosco, Francesca; Bara, Bruno G.; Cossa, Federico M.; Gindri, Patrizia; Sacco, Katiuscia

doi:10.1016/j.jneuroling.2015.12.003

Cited by 60 publications

(54 citation statements)

References 60 publications

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“…As far as the assessment of communicative abilities is concerned, we have developed the Assessment Battery for Communication (ABaCo; Sacco et al, 2008 ), for which normative data (Angeleri et al, 2012 ) and two equivalent forms (Bosco et al, 2012 ) are available. The ABaCo has been used in the assessment of children (Bosco et al, 2013 ), patients with schizophrenia (Colle et al, 2013 ), aphasia (Gabbatore et al, 2014 ), right brain lesion (Parola et al, 2016 ) and traumatic brain injury (TBI; Angeleri et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation of Communicative Abilities in Patients with a History of TBI: Behavioral Improvements and Cerebral Changes in Resting-State Activity

Sacco

Gabbatore

Geda

et al. 2016

Front. Behav. Neurosci.

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A targeted training program for the rehabilitation of communicative abilities—Cognitive Pragmatic Treatment (CPT)—has been developed and previously tested on a sample of patients with traumatic brain injury (TBI), whose performance was found to have improved. Since cortical plasticity has been recognized as the main mechanism of functional recovery, we investigated whether and how behavioral improvements following the training program are accompanied by brain modifications. Eight TBI patients took part in the training program and were behaviorally assessed pre- and post-treatment; six of these patients were also evaluated with pre- and post-treatment resting state (rs) functional magnetic resonance imaging (fMRI). At the end of the rehabilitation program patients showed improvement in overall communicative performance, in both comprehension and production tasks. A follow-up retest revealed the stability of these results 3 months after completing the training program. At the brain level, we found significant increases in the amplitude of low frequency fluctuation (ALFF) index in the bilateral precentral gyrus, in the right middle and superior temporal gyri, in the right cingulate gyrus, and in the left inferior parietal lobule. We discuss these differences of brain activity in terms of their possible contribution to promoting recovery.

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Section: Introductionmentioning

confidence: 99%

Rehabilitation of Communicative Abilities in Patients with a History of TBI: Behavioral Improvements and Cerebral Changes in Resting-State Activity

Sacco

Gabbatore

Geda

et al. 2016

Front. Behav. Neurosci.

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“…As described earlier, patients with right hemisphere damage have difficulty with pragmatics and communication. 14,15 A good communication ability needs verbal as well as non-verbal judgements on environment.…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of a right hemisphere lesion can interfere with pragmatic abilities, and particularly with the processing of nonliteral speech acts in which the listener has to identify the speaker's intention . Patients with right hemisphere damage frequently report a wide range of pragmatic disorders: despite the heterogeneity of their clinical profiles, these difficulties can seriously undermine their ability to effectively communicate in everyday situations …”

Section: Introductionmentioning

confidence: 99%

“…14 Patients with right hemisphere damage frequently report a wide range of pragmatic disorders: despite the heterogeneity of their clinical profiles, these difficulties can seriously undermine their ability to effectively communicate in everyday situations. 15 Thus the aim of this study is, using the database of neuropsychological tests and neuroimaging findings, to clarify the neuroimaging correlations for the Tanaka-Binet test, especially for the illogical questions. We hypothesised that the mental age values are correlated with global atrophy and hypometabolism, and illogical judgment is associated with right hemisphere hypometabolism.…”

Section: Introductionmentioning

confidence: 99%

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Alzheimer's deterioration in intellectual and neurobiological staging supports the retrogenesis model: a double dissociation between verbal/non‐verbal judgments and the left/right parieto‐temporal glucose metabolism. A retrospective data analysis from the Tajiri Project

Meguro¹,

Meguro

Takahashi³

et al. 2019

Psychogeriatrics

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Background Alzheimer disease (AD) patients demonstrate various clinical features reminiscent of children (the retrogenesis model). The Binet test is available for assessing mental development and deterioration. However, neuroimaging correlations remain to be clarified. Although AD patients also manifest social judgment disability, there are few cognitive tests, contrary to so many memory tests. Among the database, we noticed that the Binet test includes the subscale of social judgement using illogical sentences and pictures. The aim of this study is to clarify the neuroimaging correlations for the Binet test, especially for the illogical questions. Methods Forty participants were selected from the database of the Tajiri Project. The Tanaka‐Binet test was used to evaluate the mental age and the basic age. The latter is the age level at which the patient can completely accomplish all questions at the immediately lower age level and is used for calculating the mental age. Using the subtests of illogical sentences/pictures, logical judgment abilities were assessed. Using magnetic resonance imaging, we performed four‐grade visual evaluation for cortical atrophy. The cerebral metabolic rate for glucose (CMRglc) was measured using an autoradiographic method of 18F‐fluoreodeoxyglucose – positron emission tomography (FDG‐PET). Results There was a significant Spearman's correlation between the clinical stage and the basic age. Degree of frontal, temporal and hippocampal atrophy were correlated with the basic age. The entire grey matter and frontal and temporal CMRglc were associated with the basic age. The illogical sentences scores were correlated with the bilateral temporal, hippocampal and the left parieto‐temporal CMRglc, whereas the illogical picture scores were correlated with the right parieto‐temporal CMRglc. Conclusions We found that frontal and temporal atrophy as well as hypometabolism were associated with the basic age. Regarding the illogical judgment, the current PET data analysis disclosed that there may be a double dissociation between verbal/non‐verbal judgments and the left/right parieto‐temporal areas.

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“…Investigaciones previas habían descripto fallas en los pacientes con lesiones del HD en la habilidad de comprensión de prosodia, tanto emocional (Dara, Bang, Gottesman, & Hillis, 2014;Harciarek et al, 2006;Kho et al, 2008;Rymarczyk & Grabowska, 2007;Wright et al, 2016) como lingüística (Parola et al, 2016;Pell, 1998), pero no habían examinado la existencia de diferentes patrones de rendimiento entre ellas. Estas evidencias permitieron documentar el compromiso de ambos tipos de comprensión prosódica en pacientes con lesiones del HD pero no fueron suficientes para fundamentar la existencia de independencia funcional entre prosodia emocional y lingüística.…”

Section: Discussionunclassified

Disociaciones entre prosodia emocional y lingüística en pacientes con lesiones cerebrales del hemisferio derecho

et al. 2017

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Assessment of pragmatic impairment in right hemisphere damage

Cited by 60 publications

References 60 publications

Rehabilitation of Communicative Abilities in Patients with a History of TBI: Behavioral Improvements and Cerebral Changes in Resting-State Activity

Rehabilitation of Communicative Abilities in Patients with a History of TBI: Behavioral Improvements and Cerebral Changes in Resting-State Activity

Alzheimer's deterioration in intellectual and neurobiological staging supports the retrogenesis model: a double dissociation between verbal/non‐verbal judgments and the left/right parieto‐temporal glucose metabolism. A retrospective data analysis from the Tajiri Project

Disociaciones entre prosodia emocional y lingüística en pacientes con lesiones cerebrales del hemisferio derecho

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